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Apolipoprotein E And Cognitive Performance: A Meta-analysis.

B. Small, Christopher B. Rosnick, L. Fratiglioni, L. Bäckman
Published 2004 · Psychology, Medicine

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The epsilon4 allele of the apolipoprotein E (APOE) gene is a known risk factor for Alzheimer's disease and may also affect cognitive performance in normal aging. Evidence of the presence and magnitude of epsilon4-related cognitive deficits was examined with a meta-analysis of the available literature. Thirty-eight studies were included, and cognitive performance was collapsed into 8 domains. Results indicated significant APOE-epsilon4 group differences for global cognitive functioning, episodic memory, and executive functioning, in favor of non-epsilon4 carriers. In addition, older age and APOE-epsilon4 heterozygosity was associated with smaller epsilon4-related impairments. The meta-analysis results suggest that APOE-epsilon4 genotype does affect cognitive performance in healthy aging, although the influence is relatively small and specific to certain domains of cognitive performance.
This paper references
10.1038/205236a0
Medical Subject Headings
F. Rogers (1965)
10.2307/2529115
Statistical Power Analysis for the Behavioral Sciences
Jacob Cohen (1969)
10.1126/SCIENCE.3086978
Mechanisms of memory.
L. Squire (1986)
10.1161/01.ATV.3.4.310
Apolipoprotein E Polymorphism and Coronary Artery Disease
H. Menzel (1983)
10.2307/2289186
Statistical Methods for Meta-Analysis
L. Hedges (1987)
10.1126/SCIENCE.3283935
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
R. Mahley (1988)
10.1001/JAMA.1992.03490110111047
The Journal of Neuropsychiatry and Clinical Neurosciences
V. M. Bowden (1992)
10.1073/PNAS.90.5.1977
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
W. Strittmatter (1993)
The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretation
R. Reitan (1993)
10.1126/SCIENCE.8346443
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
E. Corder (1993)
10.1212/WNL.45.12.2203
Episodic memory changes are associated with the APOE- epsilon 4 allele in nondemented older adults
M. Bondi (1995)
Neuropsychological assessment, 3rd ed.
M. Lezak (1995)
10.1016/0306-4522(95)00014-A
Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes
M. Lehtovirta (1995)
10.1016/0304-3940(95)11575-H
The association of apolipoprotein E polymorphism with memory: a population based study
E. Helkala (1995)
10.1111/j.1399-0004.1996.tb02377.x
Apolipoprotein E4allele in the normal elderly: neuropsychologic and brain MRI correlates
H. Schmidt (1996)
10.1038/380715A0
Activation of medial temporal structures during episodic memory retrieval
L. Nyberg (1996)
10.1212/WNL.47.2.444
Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease
J. Growdon (1996)
10.1016/0304-3940(96)13059-7
Early effect of ApoE-ϵ4 allele on cognitive results in a group of highly performing subjects: the EVA study
C. Berr (1996)
10.1212/WNL.46.2.413
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease
M. Lehtovirta (1996)
10.1001/ARCHNEUR.1996.00550050048022
Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition.
E. Corder (1996)
10.1016/0304-3940(96)12348-X
Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study
E.-L. Helkala (1996)
10.1001/JAMA.278.16.1349
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
L. Farrer (1997)
10.1016/S0304-3940(97)00743-X
Reduced size of right hippocampus in 39- to 80-year-old normal subjects carrying the apolipoprotein E ϵ4 allele
H. Tohgi (1997)
10.1001/JAMA.1997.03550160069041
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
L. Farrer (1997)
10.1212/WNL.48.4.985
Apolipoprotein E ϵ4 allele and hippocampal volume in twins with normal cognition
B. L. Plassman (1997)
10.1016/S0003-4975(97)00757-1
Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center.
B. Tardiff (1997)
10.1001/ARCHNEUR.1997.00550210044011
Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women.
K. Yaffe (1997)
10.1111/j.1532-5415.1998.tb01532.x
The APOE ∍4 allele Is Associated with Decline on Delayed Recall Performance in Community‐Dwelling Older Adults
R. O'Hara (1998)
10.1002/ANA.410430307
Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease
C. Jack (1998)
10.1136/jnnp.65.3.322
Major decrease in the volume of the entorhinal cortex in patients with Alzheimer’s disease carrying the apolipoprotein E ε4 allele
K. Juottonen (1998)
10.1136/jnnp.64.6.742
Longitudinal SPECT study in Alzheimer’s disease: relation to apolipoprotein E polymorphism
(1998)
10.1037//0882-7974.13.1.80
Three-year changes in cognitive performance as a function of apolipoprotein E genotype: evidence from very old adults without dementia.
B. Small (1998)
10.1212/WNL.50.2.355
Apolipoprotein E genotype influences cognitive ‘phenotype’ in patients with Alzheimer's disease but not in healthy control subjects
G. Smith (1998)
10.1001/JAMA.282.1.40
The Role of APOE ∊4 in Modulating Effects of Other Risk Factors for Cognitive Decline in Elderly Persons
M. Haan (1999)
10.1212/WNL.53.2.321
APOE-ε4 count predicts age when prevalence of AD increases, then declines
J.C. S. Breitner (1999)
10.1037//0882-7974.14.2.295
Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease.
M. Bondi (1999)
10.1212/WNL.53.1.201
Preclinical memory decline in cognitively normal apolipoprotein E–ε4 homozygotes
R. Caselli (1999)
10.1016/S0197-4580(00)00097-X
The role of apolipoprotein E in Alzheimer’s disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models
K. Horsburgh (2000)
10.1001/ARCHNEUR.57.2.278
A Compendium of Neuropsychological Tests, 2nd ed
J. Nici (2000)
10.1002/1098-2272(200010)19:3<202::AID-GEPI2>3.0.CO;2-Q
Estimation of apolipoprotein E genotype‐specific relative mortality risks from the distribution of genotypes in centenarians and middle‐aged men: Apolipoprotein E gene is a “frailty gene,” not a “longevity gene”
L. Gerdes (2000)
10.1002/1096-8628(20001204)96:6<707::AID-AJMG1>3.0.CO;2-V
Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults.
J. Flory (2000)
10.1056/NEJM200008173430701
Patterns of brain activation in people at risk for Alzheimer's disease.
S. Bookheimer (2000)
10.1076/anec.7.4.217.797
Talkativeness in Cognitively Normal Women at Genetic Risk for Alzheimer’s Disease
M. Newman (2000)
10.1212/WNL.54.7.1492
APOE-ε4 is associated with memory decline in cognitively impaired elderly
M. Dik (2000)
10.1212/WNL.54.11.2082
Is APOE-ε4 a risk factor for cognitive impairment in normal aging?
B. Small (2000)
10.1212/WNL.55.1.134
Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype
S.D. Moffat (2000)
10.1159/000022153
Education, Activity, Health, Blood Pressure and Apolipoprotein E as Predictors of Cognitive Change in Old Age: A Review
K. Anstey (2000)
10.1093/GERONB/55.2.S69
Cognitive function and apolipoprotein E in very old adults: findings from the Nun Study.
K. P. Riley (2000)
10.1017/S1041610200006487
Apolipoprotein E, Cognitive Function, and Dementia in a General Population Aged 85 Years and Over
K. Juva (2000)
10.1016/S0022-510X(01)00577-9
Preclinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-e4/4 homozygotes: a replication study
R. J. Caselli (2001)
10.1017/S1041610201007864
Does Apolipoprotein E Influence Learning and Memory in the Nondemented Oldest Old?
A. Salo (2001)
10.1016/S0304-3940(00)01789-4
No association between apolipoprotein E polymorphisms and general cognitive ability in children
D. Turic (2001)
10.1212/WNL.57.12.2223
Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women
R. Cohen (2001)
10.1212/WNL.57.8.1461
Apolipoprotein E ε4 and the pattern of regional brain atrophy in Alzheimer’s disease
M. Hashimoto (2001)
10.1212/WNL.57.1.89
A gender difference in the association between APOE genotype and age-related cognitive decline
E. L. Mortensen (2001)
10.1046/j.0742-3071.2001.00588.x
Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample
E‐L. Helkala (2001)
10.1016/S0304-3940(02)00135-0
Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults
N. Pendleton (2002)
10.1037/0882-7974.17.2.194
Change in cognitive functioning associated with apoE genotype in a community sample of older adults.
S. Hofer (2002)
10.1037//0894-4105.16.2.254
The apolipoprotein E gene, attention, and brain function.
R. Parasuraman (2002)
10.1016/S0028-3932(02)00132-X
Working memory and apolipoprotein E: What’s the connection?
V. Rosen (2002)
10.1038/418932a
Ageing: Cognitive change and the APOE ɛ4 allele
I. Deary (2002)
10.1093/SLEEP/25.4.437
A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes.
R. Caselli (2002)
10.1136/jmg.39.9.639
Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population
A. Yip (2002)
10.1001/ARCHNEUR.59.7.1154
The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period.
R. Wilson (2002)
10.1002/GPS.664
Apolipoprotein E ε4 allele is not associated with the cognitive impairment in community‐dwelling normal elderly individuals
Ki Woong Kim (2002)
10.1016/S1568-1637(02)00005-3
Apolipoproteins and aging: emerging mechanisms
J. Smith (2002)
10.1136/jnnp.73.6.672
The apolipoprotein E ε2 allele and decline in episodic memory
Robert S. Wilson (2002)
10.1212/WNL.59.5.746
Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes
T. den Heijer (2002)
10.1176/JNP.14.1.58
Learning and recall in subjects at genetic risk for Alzheimer's disease.
J. Chen (2002)
10.1136/jnnp.72.6.794
Longitudinal analysis of the effect of apolipoprotein E ε4 and education on cognitive performance in elderly subjects: the PAQUID study
M. Winnock (2002)
10.1159/000066670
APOE Genotype, Memory Test Performance, and the Risk of Alzheimer’s Disease in the Canadian Study of Health and Aging
Jennifer D. Klages (2002)
10.1016/S0160-2896(02)00114-9
The influence of the e4 allele of the apolipoprotein E gene on childhood IQ, nonverbal reasoning in old age, and lifetime cognitive change
I. Deary (2003)
10.1002/PON.742
The relationship of APOE genotype to neuropsychological performance in long‐term cancer survivors treated with standard dose chemotherapy
T. Ahles (2003)
10.1212/01.WNL.0000055875.26908.24
The role of APOE-&egr;4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging
P. Bretsky (2003)
10.1017/S1355617704103044
Context-specific memory and apolipoprotein E (ApoE) ε4: Cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease
J. A. Levy (2004)
10.1037/0882-7974.19.2.367
Apolipoprotein e gene variability and cognitive functions at age 79: a follow-up of the Scottish mental survey of 1932.
I. Deary (2004)



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N. Zokaei (2020)
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Alberto Fernández (2021)
10.1080/13825585.2021.1919984
Relationship between a novel learning slope metric and Alzheimer's disease biomarkers.
D. Hammers (2021)
10.3389/fnagi.2021.627322
Apolipoprotein E ε4 Allele-Based Differences in Brain Volumes Are Largely Uniform Across Late Middle Aged and Older Hispanic/Latino- and Non-Hispanic/Latino Whites Without Dementia
A. Stickel (2021)
10.1016/j.bbi.2021.02.016
Apolipoprotein E (APOE) ε4 moderates the relationship between c-reactive protein, cognitive functioning, and white matter integrity
Thomas Wooten (2021)
10.1007/s10072-021-05383-z
ApoE4-positive multiple sclerosis patients are more likely to have cognitive impairment: a cross-sectional study
Farshid Mashayekhi (2021)
10.1186/s40478-021-01233-3
Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study
Megan A. Iida (2021)
10.1097/QAD.0000000000002840
Low CD4 nadir exacerbates the impacts of APOE ε4 on functional connectivity and memory in adults with HIV.
F. Yang (2021)
10.3233/JAD-201089
The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression.
Emma Rhodes (2021)
10.3389/fgene.2021.689756
Apolipoprotein E Genetic Variation and Its Association With Cognitive Function in Rural-Dwelling Older South Africans
C. Soo (2021)
10.1016/j.yebeh.2021.108088
The role of genetic polymorphisms in executive functioning performance in temporal lobe epilepsy
C. Doherty (2021)
10.1590/1980-57642021dn15-010007
Vascular mild cognitive impairment and its relationship to hemoglobin A1c levels and apolipoprotein E genotypes in the Dominican Republic
M. Medrano (2021)
10.1016/j.nbd.2020.105247
Quantitative endophenotypes as an alternative approach to understanding genetic risk in neurodegenerative diseases
F. Farias (2021)
10.3233/JAD-210183
Education Moderates the Negative Effect of Apolipoprotein E ɛ4 on Response Inhibition in Older Adults.
Yu-Ling Chang (2021)
10.3233/JAD-201559
Event-Related Potentials, Inhibition, and Risk for Alzheimer's Disease Among Cognitively Intact Elders.
Kathleen H. Elverman (2021)
10.1002/alz.12365
Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe.
M. Boccardi (2021)
10.3389/fnint.2021.719076
A Multivariate Assessment of Age-Related Cognitive Impairment in Octodon degus
Daniela S. Rivera (2021)
10.1111/jgs.16735
Association Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).
Jennifer A. Smith (2020)
10.3389/fneur.2020.00151
Editorial: Pathophysiologic Insights From Biomarker Studies in Neurological Disorders
S. Bittner (2020)
10.1111/epi.16673
Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy
R. Busch (2020)
10.1002/hipo.23217
The associations of the BDNF and APOE polymorphisms, hippocampal subfield volumes, and episodic memory performance across the lifespan
N. Malykhin (2020)
10.1097/EJA.0000000000001250
Apolipoprotein E ε4 and cognitive function after surgery in middle-aged and elderly Danish twins
U. Dokkedal (2020)
10.1093/geronb/gbaa126
When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ϵ2.
B. Levy (2020)
10.3233/JAD-200921
Apolipoprotein ɛ4 Affects Multiple Domains of Neuropsychological Functioning in a Sample of Elderly Hispanics.
D. C. Oviedo (2020)
10.1093/gerona/glaa116
APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline.
S. Makkar (2020)
10.1093/arclin/acaa014
Predictors of Heterogeneity in Cognitive Function: APOE-e4, Sex, Education, Depression, and Vascular Risk.
R. MacAulay (2020)
10.12659/MSM.923567
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10.3233/jad-201058
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