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The Corticomotoneurone Connection Is Normal In Parkinson's Disease

J. Dick, J. Cowan, B. Day, A. Berardelli, T. Kachi, J. Rothwell, C. Marsden
Published 1984 · Medicine

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Voluntary movements in Parkinson's disease are initiated and executed slowly1,2. It is assumed that the motor cortex and its output pathway are intact and that bradykinesia is due to abnormal motor commands delivered to a normal corticospinal system. We have tested this assumption using electrical stimulation of the motor cortex through the scalp in three patients with severe Parkinson's disease, studied during fluctuations from relatively normal mobility when receiving drugs (ON) to severe bradykinesia when not receiving drugs (OFF). Thresholds and latencies for motor cortex stimulation to excite thumb flexor muscles and the resulting fast mechanical responses were the same in both ON and OFF conditions, even though the patients were unable to execute fast thumb flexion movements voluntarily when OFF. We conclude that the excitability and conduction velocity of the corticospinal motor pathways are normal in Parkinson's disease.
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This paper is referenced by
MEG evaluation of Parkinson's diseased patients after external magnetic stimulation.
P. Anninos (2007)
10.1002/ANA.410320608
Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine
I. Jenkins (1992)
10.1098/RSBM.2012.0026
Charles David Marsden. 15 April 1938 — 29 September 1998
N. Quinn (2012)
10.1093/BRAIN/119.5.1689
Movement preparation in Parkinson's disease. Time course and distribution of movement-related potentials in a movement precueing task.
P. Praamstra (1996)
10.1016/0304-3940(87)90083-8
Different sites of action of electrical and magnetic stimulation of the human brain
B. Day (1987)
10.1017/CBO9780511545047.013
The Circuitry of the Human Spinal Cord: The pathophysiology of spasticity and parkinsonian rigidity
E. Pierrot-Deseilligny (2005)
10.1136/jnnp.49.10.1146
Fast complex arm movements in Parkinson's disease.
A. Berardelli (1986)
10.1007/978-3-642-74499-0_22
Magnetoelektrische Stimulation von motorischem Kortex und Nervenwurzeln im Kindesalter
V. Hoemberg (1989)
10.1590/S1807-55092013000200003
Comparação de inibições medulares entre indivíduos com doença de Parkinson e saudáveis
C. Silva-Batista (2013)
10.1093/BRAIN/124.11.2131
Pathophysiology of bradykinesia in Parkinson's disease.
A. Berardelli (2001)
Inducing neuroplasticity in the human motor system by transcranial magnetic stimulation: from pathophysiology to a therapeutic option in movement disorders
H. Rothkegel (2010)
10.1007/978-94-011-1976-4_19
Timing in Perceptual and Motor Tasks in Parkinson’s Disease
M. A. Pastor (1993)
10.1136/jnnp.53.10.862
Temporal movement control in patients with Parkinson's disease.
N. Teasdale (1990)
10.1016/S0967-5868(99)90595-7
Central motor conduction time in Parkinson's disease
Y. Mochizuki (1999)
10.1136/jnnp.64.2.166
Overactivity of cervical premotor neurons in Parkinson’s disease
S. Pol (1998)
10.1007/BF00237481
Motor strategies involved in the performance of sequential movements
R. Benecke (2004)
10.1017/cbo9780511545047
The Circuitry of the Human Spinal Cord: Its Role in Motor Control and Movement Disorders
E. Pierrot-Deseilligny (2005)
10.1136/jnnp.50.6.732
Stimulation of motor tracts in motor neuron disease.
A. Berardelli (1987)
10.1016/j.parkreldis.2014.03.018
Therapeutic applications of repetitive transcranial magnetic stimulation (rTMS) in movement disorders: a review.
Nitish Kamble (2014)
10.1523/JNEUROSCI.0523-05.2005
Bradykinesia Induced by Dopamine D2 Receptor Blockade Is Associated with Reduced Motor Cortex Activity in the Rat
L. Parr-Brownlie (2005)
10.1111/J.1464-410X.1985.TB07025.X
Micturition disturbance in Parkinson's disease.
H. Fitzmaurice (1985)
10.1002/ANA.410220611
Magnetic brain stimulation: Central motor conduction studies in multiple sclerosis
C. Hess (1987)
10.1016/S0987-7053(00)00236-7
Neurophysiological characterization of parkinsonian syndromes
J. Valls-Solé (2000)
10.1523/JNEUROSCI.22-11-04639.2002
Enhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson's Disease
J. Goldberg (2002)
10.1002/ANA.410370208
Changes in excitability of motor cortical circuitry in patients with parkinson's disease
M. C. Ridding (1995)
10.1016/0022-510X(92)90135-8
Magnetic stimulation of motor cortex in relation to fastest voluntary motor activity in neurologically asymptomatic HIV-positive patients
G. Arendt (1992)
10.1007/978-3-642-47601-3_7
Befunde bei verschiedenen Krankheiten
C. Fauth (1992)
10.1111/j.1600-0404.1989.tb03810.x
Central motor conduction time in patients with HTLV‐1 associated myelopathy
I. Tomita (1989)
10.1002/MDS.870050305
Central motor conduction to hand and leg muscles in Huntington's disease
V. Hoemberg (1990)
10.1016/S0165-0173(01)00158-8
Transcranial magnetic stimulation and Parkinson’s disease
R. Cantello (2002)
10.1007/s11255-011-9969-y
Urinary tract dysfunction in Parkinson’s disease: a review
Lehana Yeo (2011)
Movement preparation in Parkinson's disease
P. (2017)
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