Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

The Corticomotoneurone Connection Is Normal In Parkinson's Disease

J. Dick, J. Cowan, B. Day, A. Berardelli, T. Kachi, J. Rothwell, C. Marsden
Published 1984 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Voluntary movements in Parkinson's disease are initiated and executed slowly1,2. It is assumed that the motor cortex and its output pathway are intact and that bradykinesia is due to abnormal motor commands delivered to a normal corticospinal system. We have tested this assumption using electrical stimulation of the motor cortex through the scalp in three patients with severe Parkinson's disease, studied during fluctuations from relatively normal mobility when receiving drugs (ON) to severe bradykinesia when not receiving drugs (OFF). Thresholds and latencies for motor cortex stimulation to excite thumb flexor muscles and the resulting fast mechanical responses were the same in both ON and OFF conditions, even though the patients were unable to execute fast thumb flexion movements voluntarily when OFF. We conclude that the excitability and conduction velocity of the corticospinal motor pathways are normal in Parkinson's disease.
This paper references

This paper is referenced by
MEG evaluation of Parkinson's diseased patients after external magnetic stimulation.
P. Anninos (2007)
Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine
I. Jenkins (1992)
Charles David Marsden. 15 April 1938 — 29 September 1998
N. Quinn (2012)
Movement preparation in Parkinson's disease. Time course and distribution of movement-related potentials in a movement precueing task.
P. Praamstra (1996)
Different sites of action of electrical and magnetic stimulation of the human brain
B. Day (1987)
The Circuitry of the Human Spinal Cord: The pathophysiology of spasticity and parkinsonian rigidity
E. Pierrot-Deseilligny (2005)
Fast complex arm movements in Parkinson's disease.
A. Berardelli (1986)
Magnetoelektrische Stimulation von motorischem Kortex und Nervenwurzeln im Kindesalter
V. Hoemberg (1989)
Comparação de inibições medulares entre indivíduos com doença de Parkinson e saudáveis
C. Silva-Batista (2013)
Pathophysiology of bradykinesia in Parkinson's disease.
A. Berardelli (2001)
Inducing neuroplasticity in the human motor system by transcranial magnetic stimulation: from pathophysiology to a therapeutic option in movement disorders
H. Rothkegel (2010)
Timing in Perceptual and Motor Tasks in Parkinson’s Disease
M. A. Pastor (1993)
Temporal movement control in patients with Parkinson's disease.
N. Teasdale (1990)
Central motor conduction time in Parkinson's disease
Y. Mochizuki (1999)
Overactivity of cervical premotor neurons in Parkinson’s disease
S. Pol (1998)
Motor strategies involved in the performance of sequential movements
R. Benecke (2004)
The Circuitry of the Human Spinal Cord: Its Role in Motor Control and Movement Disorders
E. Pierrot-Deseilligny (2005)
Stimulation of motor tracts in motor neuron disease.
A. Berardelli (1987)
Therapeutic applications of repetitive transcranial magnetic stimulation (rTMS) in movement disorders: a review.
Nitish Kamble (2014)
Bradykinesia Induced by Dopamine D2 Receptor Blockade Is Associated with Reduced Motor Cortex Activity in the Rat
L. Parr-Brownlie (2005)
Micturition disturbance in Parkinson's disease.
H. Fitzmaurice (1985)
Magnetic brain stimulation: Central motor conduction studies in multiple sclerosis
C. Hess (1987)
Neurophysiological characterization of parkinsonian syndromes
J. Valls-Solé (2000)
Enhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson's Disease
J. Goldberg (2002)
Changes in excitability of motor cortical circuitry in patients with parkinson's disease
M. C. Ridding (1995)
Magnetic stimulation of motor cortex in relation to fastest voluntary motor activity in neurologically asymptomatic HIV-positive patients
G. Arendt (1992)
Befunde bei verschiedenen Krankheiten
C. Fauth (1992)
Central motor conduction time in patients with HTLV‐1 associated myelopathy
I. Tomita (1989)
Central motor conduction to hand and leg muscles in Huntington's disease
V. Hoemberg (1990)
Transcranial magnetic stimulation and Parkinson’s disease
R. Cantello (2002)
Urinary tract dysfunction in Parkinson’s disease: a review
Lehana Yeo (2011)
Movement preparation in Parkinson's disease
P. (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar