Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Domain Structure Of Human Glucocorticoid Receptor And Its Relationship To The V-erb-A Oncogene Product

C. Weinberger, S. M. Hollenberg, M. Rosenfeld, R. Evans
Published 1985 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The interaction of steroids with their nuclear receptors induces a cascade of regulatory events that results from the activation of specific sets of genes by the hormone/receptor complex1. Steroids, either acting alone or possibly synergistically with other growth factors, can influence the DNA synthesis and proliferation of specific target cells, initiate developmental pathways and activate expression of the differentiated phenotype2–7. Moreover, steroid hormones have been implicated in abnormal growth regulation both in tumours and tumour-derived cell lines8,9. The identification of complementary DNAs encoding the human glucocorticoid receptor (hGR) predicts two protein forms (α and β; 777 and 742 amino acids long, respectively) which differ at their carboxy termini10. We report here that both forms of the receptor are related, with respect to their domain structure, to the v-erb-A oncogene product of avian erythroblastosis virus (AEV), which suggests that steroid receptor genes and the c-erb-A proto-oncogene are derived from a common primordial regulatory gene. Therefore, oncogenicity by AEV may result, in part, from the inappropriate activity of a truncated steroid receptor or a related regulatory molecule encoded by v-erb-A. This suggests a mechanism by which transacting factors may facilitate transformation. We also identify a short region of hGR that is homologous with the Drosophila homoeotic proteins encoded by Antennapedia and fushi tarazu.
This paper references
10.1016/0092-8674(85)90306-X
The engrailed locus of drosophila: Structural analysis of an embryonic transcript
S. Poole (1985)
10.1016/0042-6822(83)90125-3
Site-specific mutagenesis of avian erythroblastosis virus: erb-B is required for oncogenicity.
L. Sealy (1983)
10.1038/256592A0
Oestrogen-responsive human breast cancer in long term tissue culture
MARC E. Lippman (1975)
10.1016/0012-1606(68)90010-9
In vitro induction of physiological maturation in Rana pipiens oocytes removed from their ovarian follicles.
L. D. Smith (1968)
10.1002/j.1460-2075.1985.tb03825.x
Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.
J. Miller (1985)
10.1016/S0092-8674(80)80048-1
Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes
D. Engelke (1980)
10.1016/0042-6822(85)90457-X
The four C-terminal amino acids of the v-erbA polypeptide are encoded by an intronic sequence of the v-erbB oncogene.
C. Henry (1985)
10.1146/ANNUREV.PH.42.030180.000313
Dynamics of steroid hormone receptor action.
B. Katzenellenbogen (1980)
10.1073/PNAS.81.13.4115
Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.
M. Scott (1984)
10.1126/SCIENCE.7280687
Similar amino acid sequences: chance or common ancestry?
R. Doolittle (1981)
10.1038/313545A0
Segmental distribution of bithorax complex proteins during Drosophila development
P. Beachy (1985)
10.1146/ANNUREV.PH.38.030176.002233
Current models of steroid hormone action: a critique.
J. Gorski (1976)
10.1126/SCIENCE.2581314
Identification of human glucocorticoid receptor complementary DNA clones by epitope selection.
C. Weinberger (1985)
10.1146/ANNUREV.PA.25.040185.002525
Steroid hormone regulation of gene expression.
G. Ringold (1985)
10.1002/j.1460-2075.1982.tb01161.x
Active domains in wild‐type and mutant glucocorticoid receptors.
H. Dellweg (1982)
10.1146/ANNUREV.NE.07.030184.002213
Gonadal steroid induction of structural sex differences in the central nervous system.
A. Arnold (1984)
10.1126/SCIENCE.6328658
Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene.
B. Debuire (1984)
10.1038/310025A0
Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins
A. Laughon (1984)
10.1016/B978-0-12-526302-3.50009-5
The Role of Receptors in the Anabolic Action of Androgens
C. W. Bardin (1978)
10.1038/309806A0
Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells
Young-hua Xu (1984)
10.1126/SCIENCE.2992089
Amplification of a novel v-erbB-related gene in a human mammary carcinoma.
C. R. King (1985)
10.1038/309418A0
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
A. Ullrich (1984)
10.1038/318635A0
Primary structure and expression of a functional human glucocorticoid receptor cDNA
S. M. Hollenberg (1985)
10.1016/0092-8674(80)90385-2
A control region in the center of the 5S RNA gene directs specific initiation of transcription: II. The 3′ border of the region
D. Bogenhagen (1980)
10.1002/j.1460-2075.1983.tb01463.x
Isolation and characterization of multiple human genes homologous to the oncogenes of avian erythroblastosis virus.
M. Jansson (1983)
10.1016/s0021-9258(17)43079-1
Characterization of the purified activated glucocorticoid receptor from rat liver cytosol.
O. Wrange (1984)
10.1073/PNAS.79.14.4260
Immunochemical analysis of the glucocorticoid receptor: identification of a third domain separate from the steroid-binding and DNA-binding domains.
J. Carlstedt-Duke (1982)
10.1016/0092-8674(83)90209-X
The erbB gene of avian erythroblastosis virus is a member of the src gene family
T. Yamamoto (1983)
10.1007/978-1-4757-4619-8_6
Insect Hormones and the Regulation of Genetic Activity
G. Richards (1984)
10.1038/308428A0
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes
W. McGinnis (1984)
10.1126/SCIENCE.2992090
The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor.
A. Schechter (1985)
10.1126/SCIENCE.6326261
Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells.
C. Lin (1984)
10.1016/0092-8674(83)90513-5
Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes
L. Frykberg (1983)
10.1002/j.1460-2075.1985.tb03889.x
Distribution of Ultrabithorax proteins in Drosophila
R. A. White (1985)
10.1016/0092-8674(84)90455-0
Xenopus 5S gene transcription factor, TFIIIA: Characterization of a cDNA clone and measurement of RNA levels throughout development
A. Ginsberg (1984)
Breast cancer : trends in research and treatment
Jean-Claude Heuson (1976)



This paper is referenced by
10.1016/S0960-0760(02)00062-6
Glucocorticoid receptor variants: clinical implications
R. Derijk (2002)
10.1007/BF03350080
The molecular basis of thyroid hormone action
L. J. DeGroot (1989)
10.1016/S0065-230X(08)60304-8
c-erbA: protooncogene or growth suppressor gene?
K. Damm (1992)
10.18725/OPARU-1913
Species specific aspects of ecdysteroid receptor response to ecdysteroids and juvenile hormone
J. Beatty (2011)
10.20381/ruor-4609
Understanding C/EBPbeta LAP/LIP Transcriptional and Adipogenic Potential Through Regulation by HDAC1 and GCN5
Houssein S. Abdou (2011)
10.1016/0092-8674(87)90753-7
Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor
S. M. Hollenberg (1987)
10.1007/978-1-4471-3879-2
Zinc in Human Biology
C. Mills (1989)
10.1038/334543a0
The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain
L. Freedman (1988)
10.1007/978-3-642-74158-6_1
Animal receptors ― Examples of cellular signal perception molecules
M. Hahn (1989)
10.1016/0092-8674(86)90659-8
Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA
R. Miesfeld (1986)
10.1002/9780470166383.CH3
Metal-Binding Domains in Nucleic Acid-Binding and Gene-Regulatory Proteins
J. Berg (2007)
Molecular Chaperones and Cochaperones as Regulators of the Transcriptional Activity of the Glucocorticoid Receptor
Wissenschaftliche Berichte (2003)
10.1006/GCEN.1999.7196
Cloning, in vitro expression, and novel phylogenetic classification of a channel catfish estrogen receptor.
Z. Xia (1999)
10.1038/nm1004-1022
A transcriptional basis for physiology
R. Evans (2004)
10.1021/BI00410A034
Identification of cysteine-644 as the covalent site of attachment of dexamethasone 21-mesylate to murine glucocorticoid receptors in WEHI-7 cells.
L. Smith (1988)
10.1007/978-3-642-71506-8_2
Experimental Strategies for Studying the Development of Breast Cancer with Special Reference to Steroid Hormones, Growth Factors and Oncogenes
R. B. King (1986)
10.1007/978-3-663-20178-6_1
Neue Aspekte zu Physiologie und Pharmakologie der Glukokortikoide
H. L. Fehm (1988)
Einfluss der Histon Deacetylase 6 auf den Glucocorticoid Rezeptor-vermittelten Glucosestoffwechsel
R. Winkler (2012)
10.1016/0022-4731(88)90069-6
Studies with antibodies against the conserved cysteine region of progesterone receptor.
D. Smith (1988)
10.1016/0303-7207(86)90064-X
Affinity labelling of steroid hormone receptors
H. Gronemeyer (1986)
10.1128/MCB.7.12.4582
RNA polymerase II transcription factors H4TF-1 and H4TF-2 require metal to bind specific DNA sequences.
L. Dailey (1987)
10.1046/j.1464-410x.2000.00943.x
Androgen receptor signalling in the prostate
V. Gnanapragasam (2000)
Tissue-specific Regulation of Glucocorticoid Receptor mRNA by
Judith E. KalinyakS (1987)
10.5555/URI:PII:027092959090015R
Corticosteroid receptors and renal 11 beta-hydroxysteroid dehydrogenase activity.
J. Funder (1990)
10.1007/978-3-663-01944-2_1
Rezeptoraffinität synthetischer Glukokortikoide
R. Schlaghecke (1992)
10.1038/318635A0
Primary structure and expression of a functional human glucocorticoid receptor cDNA
S. M. Hollenberg (1985)
10.1007/BF01953055
The evolutionary conservation of eukaryotic gene transcription
M. Schena (2005)
10.1016/0092-8674(89)90903-3
Functional dissection and sequence of yeast HAP1 activator
Karl Pfeifer (1989)
10.1007/978-1-4612-3718-1_8
Growth Factors and Receptors
K. Burck (1988)
10.1016/0165-6147(87)90022-8
Glucocorticoids: new insights into their molecular mechanisms
M. Alexis (1987)
10.1126/SCIENCE.3283939
The steroid and thyroid hormone receptor superfamily.
R. Evans (1988)
10.1007/978-3-642-73325-3_29
Regulation of Gene Expression by Steroid Hormones
M. Beato (1986)
See more
Semantic Scholar Logo Some data provided by SemanticScholar