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In Vitro Selection Of RNA Molecules That Bind Specific Ligands

A. Ellington, J. Szostak
Published 1990 · Biology, Medicine

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Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 1010 random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.
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