Online citations, reference lists, and bibliographies.
← Back to Search

A Human Homologue Of The Yeast HDEL Receptor

M. Lewis, H. Pelham
Published 1990 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
RETENTION of resident proteins in the lumen of the endoplasmic reticulum is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment1–3. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually Lys-Asp-Glu-Leu (KDEL in the single letter code) in animal cells, His-Asp-Glu-Leu (HDEL) in Sac-charomyces cerevisiae2,4,5. There is evidence that the ERD2 gene encodes the sorting receptor that recognizes HDEL in yeast6,7; its product is an integral membrane protein of relative molecular mass 26,000 (26K) that is not glycosylated. In contrast, Vaux et al.8 suggest that the mammalian KDEL receptor is a 72K gly-coprotein that they detected using an anti-idiotypic antibody approach. If this were so, it would indicate a surprising divergence of the retrieval machinery between yeast and animal cells. We report here that human cells express a protein similar in sequence, size and properties to the ERD2 product, and propose that this protein is the human KDEL receptor.
This paper references
Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae
J. Roth (1982)
Sorting of soluble ER proteins in yeast.
H. Pelham (1988)
Recycling of proteins from the Golgi compartment to the ER in yeast
N. Dean (1990)
A simple method for displaying the hydropathic character of a protein.
J. Kyte (1982)
Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor.
H. G. Dohlman (1988)
Control of protein exit from the endoplasmic reticulum.
H. Pelham (1989)
Pre- and post-golgi vacuoles operate in the transport of semliki forest virus membrane glycoproteins to the cell surface
J. Saraste (1984)
A C-terminal signal prevents secretion of luminal ER proteins
S. Munro (1987)
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.
R. Saiki (1988)
ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway
J. C. Semenza (1990)
Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal
D. Vaux (1990)
The ERD2 gene determines the specificity of the luminal ER protein retention system
M. Lewis (1990)
Evidence that luminal ER proteins are sorted from secreted proteins in a post‐ER compartment.
H. Pelham (1988)
The Fcγ receptor of natural killer cells is a phospholipid-linked membrane protein
D. Simmons (1988)
Signals and salvage sequences
G. Warren (1987)
Structure-Function Analysis of the β-Adrenergic Receptor
Rn Dixon (1988)

This paper is referenced by
Overexpression of an Anti-CD3 Immunotoxin Increases Expression and Secretion of Molecular Chaperone BiP/Kar2p by Pichia pastoris
Y. Y. Liu (2005)
Regulation of the Secretory Pathway
A. Capalbo (2016)
Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP
N. Mimura (2007)
The -Glucuronidase Propeptide Contains a Serpin-related Octamer Necessary for Complex Formation with Egasyn Esterase and for Retention within the Endoplasmic Reticulum (*)
L. Zhen (1995)
Role of human protein disulfide isomerase (PDI) in the redox regulation of anthrax receptor 2 (ANTXR2)
Naima Mohamed Alshrif (2012)
Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen
M. Satoh (1996)
Mechanism of pFGE and FGE Retention in Endoplasmic Reticulum
S. Gande (2007)
Intermediate compartment (IC): from pre-Golgi vacuoles to a semi-autonomous membrane system
J. Saraste (2018)
KDEL receptor is a cell surface receptor that cycles between the plasma membrane and the Golgi via clathrin-mediated transport carriers
Jie Jia (2020)
Rer1p as common machinery for the endoplasmic reticulum localization of membrane proteins.
K. Sato (1997)
A self-contained system for the field production of plant recombinant interleukin-10
R. Menassa (2004)
Brefeldin A revealing the fundamental principles governing membrane dynamics and protein transport.
C. Jackson (2000)
Development of transgenic Arabidopsis thaliana and Daucus carota plant producing the p24 capsid protein from HIV-1 subtype C for the use as an edible plant-based vaccine model
Ingrid Lindh (2009)
Quality Control in the Early Secretory Pathway Plays Significant Roles in vivo
T. Aoe (2011)
Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum
M. Lewis (1992)
Antibody and HIV-1 gpl20 recognition of CD4 undermines the concept of mimicry between antibodies and receptors
S. Davis (1992)
Involvement of the stress protein HSP47 in procollagen processing in the endoplasmic reticulum
A. Nakai (1992)
Signal-mediated sorting of membrane proteins between the endoplasmic reticulum and the golgi apparatus.
R. Teasdale (1996)
Predominant Golgi Residency of the Plant K/HDEL Receptor Is Essential for Its Function in Mediating ER Retention[CC-BY]
Fernanda A L Silva-Alvim (2018)
Functional dissection of alternative secretory pathways in the yeast S. cerevisiae
R. Bastos (2008)
A molecular specificity code for the three mammalian KDEL receptors
Irina B Raykhel (2007)
Recruitment to Golgi membranes of ADP‐ribosylation factor 1 is mediated by the cytoplasmic domain of p23
D. Gommel (2001)
Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.
F. Muñoz-Lobato (2014)
Dilated Cardiomyopathy Caused by Aberrant Endoplasmic Reticulum Quality Control in Mutant KDEL Receptor Transgenic Mice
H. Hamada (2004)
Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER
Aurélia Boulaflous (2009)
Role of EBAG9 in COPI-dependent glycoprotein maturation and secretion processes in tumor cells
J. Wolf (2010)
Architecture of the mammalian Golgi.
J. Klumperman (2011)
Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain
M. Sato (1996)
A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway
T. Pulvirenti (2008)
Head-to-tail oligomerization of calsequestrin
G. Gatti (2001)
In silico approach to predict pancreatic β-cells classically secreted proteins
Erika Pinheiro-Machado (2020)
COPI-mediated protein and lipid sorting in the early secretory pathway
W. Nickel (2005)
See more
Semantic Scholar Logo Some data provided by SemanticScholar