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A Novel Heterodimeric Cysteine Protease Is Required For Interleukin-1βprocessing In Monocytes

Nancy A. Thornberry, Herbert G. Bull, Jimmy R. Calaycay, K. Chapman, A. Howard, Matthew J. Kostura, D. Miller, Susan M. Molineaux, J. Weidner, J. Auniņš, Keith O. Elliston, J. Ayala, Francesca J. Casano, J. Chin, Gloria J.-F. Ding, Linda A. Egger, E. Gaffney, G. Limjuco, Oksana C. Palyha, S. M. Raju, Anna M. Rolando, J. Salley, Ting-ting D Yamin, Terry D. Lee, John E. Shively, Malcolm Maccross, R. Mumford, John A. Schmidt, Michael J. Tocci
Published 1992 · Biology, Medicine

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Interleukin-1β (IL-1β)-converting enzyme cleaves the IL-1β precursor to mature IL-1β, an important mediator of inflammation. The identification of the enzyme as a unique cysteine protease and the design of potent peptide aldehyde inhibitors are described. Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis. Selective inhibition of the enzyme in human blood monocytes blocks production of mature IL-1β, indicating that it is a potential therapeutic target.
This paper references
Amino acid sequence analysis of human interleukin 1 (IL-1). Evidence for biochemically distinct forms of IL-1
P. Cameron (1985)
PCR protocols: a guide to methods and applications.
M. Innis (1990)
Substrate specificity of the protease that processes human interleukin-1 beta.
P. Sleath (1990)
A gas-liquid solid phase peptide and protein sequenator.
R. Hewick (1981)
The protein identification resource (PIR).
D. George (1986)
Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells.
R. Schindler (1990)
Comparative analysis of viral cysteine protease structural models
J. Bazan (1989)
Molecular Cloning: A Laboratory Manual
J. Sambrook (1983)
Structural analysis of proteins by capillary HPLC electrospray tandem mass spectrometry
P. Griffin (1991)
A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact
C. Perez (1990)
Purification of angiotensin-converting enzyme from rabbit lung and human plasma by affinity chromatography.
H. Bull (1985)
Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.
I. Clark-lewis (1991)
A comprehensive set of sequence analysis programs for the VAX
J. Devereux (1984)
The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.
B. Mosley (1987)
Transition State Analogues for Enzyme Catalysis
R. Wolfenden (1969)
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
C. Hannum (1990)
IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
A. Howard (1991)
The slow-binding and slow, tight-binding inhibition of enzyme-catalysed reactions
John F. Morrison (1982)
A specific receptor antagonist for interleukin 1 prevents Escherichia coli‐induced shock in rabbits
G. Wakabayashi (1991)
Determination of the minimum polypeptide lengths of the functionally active sites of human interleukins 1 alpha and 1 beta.
B. Mosley (1987)
Tandem quadrupole Fourier-transform mass spectrometry of oligopeptides and small proteins.
D. Hunt (1987)
Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor.
W. Fanslow (1990)
Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody
K. McIntyre (1991)
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
S. P. Eisenberg (1990)
Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate.
H. Nagase (1990)
Reversible inactivation of rabbit muscle aldolase by ophenanthroline.
Kyoichi Kobashi (1967)
Molecular cloning and sequence analysis of cDNA for batroxobin, a thrombin-like snake venom enzyme.
N. Itoh (1987)
Processing of precursor interleukin 1 beta and inflammatory disease.
D. Hazuda (1990)
Peptide Growth Factors and Their Receptors I
新井 健一 (1991)
Interleukin-1 receptor antagonist reduces mortality from endotoxin shock
K. Ohlsson (1990)
The scanning model for translation: an update
M. Kozak (1989)
The molecular evolution of genes and proteins: a tale of two serines
S. Brenner (1988)
The GenBank genetic sequence databank
H. Bilofsky (1986)
Activation of interleukin‐ 1β by a co‐induced protease
R. Black (1989)
Identification of a monocyte specific pre-interleukin 1 beta convertase activity.
M. Kostura (1989)
Differences in the synthesis and kinetics of release of interleukin 1α, interleukin 1β and tumor necrosis factor from human mononuclear cells
G. Lonnemann (1989)

This paper is referenced by
Characterization of the S1 binding site of the glutamic acid‐specific protease from Streptomyces griseus
Henning R. Stennicke (1996)
In situ visualization of caspase‐1‐like activity associated with promotion of hippocampal cell death
W. Nishii (2002)
NLRP6 deficiency aggravates liver injury after allogeneic hematopoietic stem cell transplantation.
M. Li (2019)
The medical significance of physiological cell death
Georg Häucker (1995)
Science Journals — AAAS
Justin L Penn (2017)
Cell surface IL‐1α trafficking is specifically inhibited by interferon‐γ, and associates with the membrane via IL‐1R2 and GPI anchors
Julie N. E. Chan (2020)
Anti-Inflammatory Effect of Adipose-Derived Mesenchymal Stem Cells for Flexor Tendon Healing
C. N. Manning (2013)
Dipeptidyl peptidase IV (CD 26) and aminopeptidase N (CD 13) catalyzed hydrolysis of cytokines and peptides with N‐terminal cytokine sequences
T. Hoffmann (1993)
EI-2346, a novel interleukin-1beta converting enzyme inhibitor produced by Streptomyces sp. E-2346. II. Structure elucidation.
F. Koizumi (2004)
Cellular Proteolysis An Overview
A. Barrett (1992)
Involvement of ICE-Like Proteases in Gemcitabine-Induced Programmed Cell Death
O. Stoetzer (1998)
Cloning and Expression of Four Novel Isoforms of Human Interleukin-1β Converting Enzyme with Different Apoptotic Activities (*)
E. Alnemri (1995)
Synthesis and evaluation of diacylhydrazines as inhibitors of the interleukin-1β converting enzyme (ICE)
T. L. Graybill (1995)
Cleavage of Poly(ADP-ribose) Polymerase by Interleukin-1β Converting Enzyme and Its Homologs TX and Nedd-2 (*)
Y. Gu (1995)
Evolutionary conservation of a genetic pathway of programmed cell death
J. Yuan (1996)
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
D. Nicholson (1996)
Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species
J. Schulz (1996)
Ceramide induces apoptosis via CPP32 activation
N. Mizushima (1996)
Fas expression and function in normal and malignant breast cell lines.
M. Keane (1996)
Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin
D. Ferrari (1997)
Endogenous Bax Translocation in SH‐SY5Y Human Neuroblastoma Cells and Cerebellar Granule Neurons Undergoing Apoptosis
K. McGinnis (1999)
Viral modulation of the host response via crmA/SPI‐2 expression
S. Turner (1999)
Interleukin-1 Receptor Signaling Is Required To Overcome the Effects of Pertussis Toxin and for Efficient Infection- or Vaccination-Induced Immunity against Bordetella pertussis
Xuqing Zhang (2010)
Failure to activate interleukin 1β‐converting enzyme‐like proteases and to cleave retinoblastoma protein in drug‐resistant cells
B. An (1996)
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).
T. Rano (1997)
Structure and Function of Interleukin-1β Converting Enzyme
M. Tocci (1997)
Biochemical and molecular mechanisms regulating apoptosis
K. Saini (2004)
CD95(APO-1/Fas)-mediated apoptosis: live and let die.
Peter H. Krammer (1999)
Molecular mechanisms of apoptosis induced by an immunomodulating peptide on human monocytes.
J. Oses-Prieto (2000)
Isolation and assay of caspases.
S. Srinivasula (2001)
Peptidyl β-homo-aspartals : Specific inhibitors of interleukin-1β converting enzyme and its homologues (caspases)
S. Bajusz (1998)
Detection of activated Caspase-3 by a cleavage site-directed antiserum during naturally occurring DRG neurons apoptosis.
Y. Kouroku (1998)
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