Online citations, reference lists, and bibliographies.
← Back to Search

A Role For Melanin-concentrating Hormone In The Central Regulation Of Feeding Behaviour

D. Qu, D. Ludwig, S. Gammeltoft, M. Piper, M. A. Pelleymounter, M. J. Cullen, W. Mathes, Jeanne Przypek, R. Kanarek, E. Maratos-Flier
Published 1996 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
THE hypothalamus plays a central role in the integrated regulation of energy homeostasis and body weight, and a number of hypothalamic neuropeptides, such as neuropeptide Y (ref. 1), galanin2, CRH (ref. 3), and GLP-1 (ref. 4), have been implicated in the mediation of these effects. To discover new hypothalamic peptides involved in the regulation of body weight, we used differential display polymerase chain reaction5 to identify messenger RNAs that are differentially expressed in the hypothalamus of ob/+ compared with ob/ob C57B1/6J mice. We show here that one mRNA that is overexpressed in the hypothalamus of ob/ob mice encodes the neuropeptide melanin-concentrating hormone (MCH). Fasting further increased expression of MCH mRNA in both normal and obese animals. Neurons containing MCH are located in the zona incerta and in the lateral hypothalamus. These areas are involved in regulation of ingestive behaviour, but the role of MCH in mammalian physiology is unknown. To determine whether MCH is involved in the regulation of feeding, we injected MCH into the lateral ventricles of rats and found that their food consumption increased. These findings suggest that MCH participates in the hypothalamic regulation of body weight.
This paper references
10.1073/PNAS.92.11.4728
Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.
M. Klebig (1995)
10.1111/j.1749-6632.1993.tb19694.x
Cloning and Functional Characterization of a Family of Receptors for the Melanotropic Peptides
R. Cone (1993)
10.1126/SCIENCE.1354393
Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.
P. Liang (1992)
10.1073/PNAS.83.5.1528
Melanin-concentrating hormone: unique peptide neuronal system in the rat brain and pituitary gland.
N. Zamir (1986)
10.1111/j.1749-6632.1993.tb19675.x
Chemistry of Melanin‐Concentrating Hormone
H. Kawauchi (1993)
10.1038/372425A0
Positional cloning of the mouse obese gene and its human homologue
Y. Zhang (1994)
10.1089/DNA.1990.9.637
Nucleotide sequence and tissue-specific expression of the rat melanin concentrating hormone gene.
R. Thompson (1990)
10.1016/0031-9384(89)90251-5
Repeated hypothalamic stimulation with neuropeptide Y increases daily carbohydrate and fat intake and body weight gain in female rats
B. G. Stanley (1989)
10.1016/0361-9230(90)90177-2
Diurnal variations in the feeding responses to norepinephrine, neuropeptide Y and galanin in the PVN
D. Tempel (1990)
10.1002/CNE.903190204
The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization
J. Bittencourt (1992)
10.1006/mcne.1993.1035
Structure and Regulation of the Mouse Melanin-Concentrating Hormone mRNA and Gene
C. Breton (1993)
10.1126/SCIENCE.7624776
Effects of the obese gene product on body weight regulation in ob/ob mice.
M. A. Pelleymounter (1995)
10.1210/ENDO.131.4.1327720
Secretion of melanin-concentrating hormone and neuropeptide-EI from cultured rat hypothalamic cells.
D. Parkes (1992)
10.1038/379069A0
A role for glucagon-like peptide-1 in the central regulation of feeding
M. Turton (1996)
10.1016/0014-2999(86)90175-5
Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide.
S. E. Kyrkouli (1986)
10.1210/ENDO-127-2-730
Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation.
G. Sanacora (1990)
10.1002/CNE.902720410
Neurochemical organization of the hypothalamic projection to the spinal cord in the rat
D. Cechetto (1988)
10.1016/0196-9781(89)90112-5
Melanin concentrating hormone (MCH): Structure-function aspects of its melanocyte stimulating hormone-like (MSH-like) activity
T. Matsunaga (1989)
10.1016/S0092-8674(05)80067-4
Molecular characterization of the mouse agouti locus
Scott J. Bultman (1992)
10.1016/0304-3940(92)90035-6
Immunoreactivities for antisera to three putative neuropeptides of the rat melanin-concentrating hormone precursor are coexpressed in neurons of the rat lateral dorsal hypothalamus
P. Risold (1992)
10.1038/305321A0
Characterization of melanin-concentrating hormone in chum salmon pituitaries
H. Kawauchi (1983)
10.1111/j.1749-6632.1993.tb19678.x
Structure and Regulation of the Melanin‐Concentrating Hormone Gene a
J. L. Nahon (1993)
10.1016/0361-9230(85)90213-8
Immunohistochemical localization of a melanin concentrating hormone-like peptide in the rat brain
G. Skofitsch (1985)
10.1016/0016-6480(79)90047-9
The teleost melanin-concentrating hormone -- a pituitary hormone of hypothalamic origin.
T. Rance (1979)
10.1038/371799A0
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
D. Lu (1994)
10.1210/ENDO-125-4-2056
The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus.
J. L. Nahon (1989)



This paper is referenced by
10.1152/jn.00522.2012
Reversed synaptic effects of hypocretin and NPY mediated by excitatory GABA-dependent synaptic activity in developing MCH neurons.
Y. Li (2013)
10.1038/clpt.2011.253
The Genetics of Anorexia Nervosa
T. Clarke (2012)
10.1016/j.neuropharm.2011.04.022
Activation of orexin neurons in dorsomedial/perifornical hypothalamus and antidepressant reversal in a rodent model of depression
M. Nollet (2011)
10.1590/S0100-879X2010007500059
Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides.
L. Silva (2010)
10.1371/journal.pone.0059809
Nesfatin-1/NUCB2 as a Potential New Element of Sleep Regulation in Rats
S. Vas (2013)
10.1007/400_2007_052
The melanin-concentrating hormone system and its physiological functions.
Y. Saito (2008)
10.1016/j.neuroscience.2012.03.024
Animal models of eating disorders
S. Kim (2012)
10.1016/J.BMCL.2006.07.008
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists.
Donald L. Hertzog (2006)
10.1007/978-3-642-59651-3_13
Central Nervous System Neuropeptides Involved in Obesity
M. Rossi (2000)
10.1254/FPJ.127.190
[Finding a novel target for depression through the orphan receptor strategy].
Y. Saito (2006)
PARTICIPAÇÃO DO FATOR LIBERADOR DE CORTICOTROFINA NOS EFEITOS DO ESTRADIOL NO CONTROLE DA HOMEOSTASE ENERGÉTICA
Departamento de Fisiologia (2011)
10.1152/ajpregu.00452.2011
Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons.
Y. Yao (2012)
Insulin regulates Energy Homeostasis and Hypoglycemia in the Ventromedial Hypothalamus
K. Tim (2011)
Bedeutung komplexer Kohlenhydrate in der Regulation der Ghrelin-Sekretion
Yvonne Hebeisen (2006)
10.1517/14728214.2.1.1
Treatments for obesity
D. Goldstein (1997)
10.1002/DDR.20030
Small molecule melanin‐concentrating hormone receptor 1 (MCH1R) antagonists as anxiolytic and antidepressive agents
B. Dyck (2005)
10.1002/JEZ.A.310
Functions of melanin-concentrating hormone in fish.
H. Kawauchi (2006)
The physiology of body weight regulation: relevance to the etiology of obesity in children.
M. Rosenbaum (1998)
10.3389/fendo.2019.00324
In vitro Radiopharmaceutical Evidence for MCHR1 Binding Sites in Murine Brown Adipocytes
T. Balber (2019)
10.1016/j.molmet.2019.11.013
A subpopulation of Bdnf-e1–expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control
H. You (2020)
10.1016/j.conb.2017.03.020
Lateral hypothalamic circuits for sleep–wake control
T. Yamashita (2017)
10.1517/14728222.10.2.211
Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances
G. Hervieu (2006)
10.1159/000318511
New insights in ghrelin orexigenic effect.
C. Dieguez (2010)
10.1016/j.cmet.2008.01.007
Activation of Stat3 signaling in AgRP neurons promotes locomotor activity.
A. Mesaros (2008)
10.1016/J.MOLBRAINRES.2004.06.010
Increases in melanin-concentrating hormone and MCH receptor levels in the hypothalamus of dietary-obese rats.
Joanne C Elliott (2004)
10.1152/AJPENDO.00114.2004
Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides.
J. Bullen (2004)
10.1016/S0079-6123(06)53008-0
Integration of metabolic stimuli in the hypothalamic arcuate nucleus.
M. van den Top (2006)
10.1007/978-1-60327-874-4_28
Neuroendocrine and Metabolic Adaptations in the Central Nervous System That Facilitate Weight Regain
R. Lechan (2010)
10.1016/j.jchemneu.2009.10.005
Chemical identity and connections of medial preoptic area neurons expressing melanin-concentrating hormone during lactation
T. A. Rondini (2010)
10.1016/S0306-4522(01)00555-3
The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
B. Oldfield (2002)
10.1002/NEU.10147
Nicotinic receptor-mediated effects on appetite and food intake.
Y. Jo (2002)
10.1177/153537020122600308
Food Restriction-like Effects of Dietary Dehydroepiandrosterone. Hypothalamic Neurotransmitters and Metabolites in Male C57BL/6 and (C57BL/6 × DBA/2)F1 Mice
F. Catalina (2001)
See more
Semantic Scholar Logo Some data provided by SemanticScholar