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Medical Genetics: A Marker For Stevens–Johnson Syndrome

Wen-hung Chung, S. Hung, Hong-Shang Hong, M. Hsih, L. Yang, Hsin-Chun Ho, J. Wu, Y. Chen
Published 2004 · Medicine

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Stevens–Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA–B*1502, and Stevens–Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens–Johnson syndrome.
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This paper is referenced by
10.1001/jamadermatol.2018.5336
Screening HLA to Prevent Severe Drug Reactions-A Devil's Advocate Perspective.
S. Divito (2019)
10.1016/j.ajhg.2010.03.011
Inferring genetic ancestry: opportunities, challenges, and implications.
C. Royal (2010)
10.1016/J.ALLERG.2005.02.013
Polymorphismes génétiques et allergies médicamenteuses
L. Guglielmi (2005)
10.1517/14622416.5.6.643
Pharmacogenetics of antiretroviral therapy: genetic variation of response and toxicity.
A. Martin (2004)
10.2217/pgs.10.97
Realities and expectations of pharmacogenomics and personalized medicine: impact of translating genetic knowledge into clinical practice.
A. Squassina (2010)
10.1186/1750-1172-5-39
Toxic epidermal necrolysis and Stevens-Johnson syndrome
T. Harr (2010)
Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications
Abdelbaset A. Elzagallaai (2011)
Bronchopulmonary involvement in severe cutaneous adverse reactions
Nicolas Prost (2013)
10.1016/B978-0-12-386882-4.00001-3
Pharmacogenomics and stratified medicine
Sandosh Padmanabhan (2014)
10.1002/14651858.CD010891
Genetic testing for prevention of severe drug-induced skin rash.
Ana Alfirevic (2013)
10.2217/pgs.15.4
Role of dermatology in pharmacogenomics: drug-induced skin injury.
Riccardo G Borroni (2015)
10.14581/jer.16016
Spectrum of Cutaneous Adverse Reactions to Levetiracetam and Human Leukocyte Antigen Typing in North-Indian Patients
B. Ramanujam (2016)
10.1016/j.nano.2016.09.009
Facile and phase-defined determination of HLA alleles with morpholino-functionalized nanoparticle probes.
Yanbing Zu (2017)
10.1016/j.jid.2017.01.003
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Associations, Outcomes, and Pathobiology-Thirty Years of Progress but Still Much to Be Done.
R. Stern (2017)
Toxic epidermal necrolysis in a breast cancer patient treated with whole brain radiotherapy and phenytoin: Should phenytoin have been used?
H. Ranu (2008)
10.1016/j.clindermatol.2007.11.007
Future perspectives/quo vadis psoriasis treatment? Immunology, pharmacogenomics, and epidemiology.
A. Kimball (2008)
"Personalized justice complements personalized medicine and the overlapping practice of translational medicine, which hold s that individual differences are caused primarily by genetic and environmental factors. "
Steven H. Wong (2010)
10.1517/14656560903508762
Pharmacogenetic considerations in the treatment of psychiatric disorders
F. Lohoff (2010)
10.1345/aph.1P053
Caspofungin-induced severe toxic epidermal necrolysis.
Ming-Chia Lee (2010)
10.1002/pst.442
Proposals of statistical consideration to evaluation of results for a specific region in multi-regional trials--Asian perspective.
H. Tsou (2010)
10.1016/B978-0-12-385471-1.00016-7
Chapter 16 – Biochemical Mechanisms of Drug Toxicity
Arthur J. Jr. Atkinson (2012)
10.1016/j.preteyeres.2012.05.003
Ocular surface inflammation is regulated by innate immunity
M. Ueta (2012)
10.1172/JCI93349
Randomized, controlled trial of TNF-&agr; antagonist in CTL-mediated severe cutaneous adverse reactions
C. Wang (2018)
10.1080/17512433.2018.1486707
Carbamazepine adverse drug reactions
I. Fricke-Galindo (2018)
10.1097/CCM.0000000000000009
Are we offtrack using propofol for sedation after traumatic brain injury?
Mark Coburn (2014)
10.1159/000433423
The Phytotherapeutic Fenugreek as Trigger of Toxic Epidermal Necrolysis
N. Bentele-Jaberg (2015)
10.1001/jamadermatol.2013.4114
Relationship between the HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis.
Wimonchat Tangamornsuksan (2013)
10.2217/pgs.10.63
From personalized medicine to personalized justice: the promises of translational pharmacogenomics in the justice system.
S. Wong (2010)
Estudio de genes hla en atlánticos y mediterráneos: celtas e íberos
Jose Manuel del Palacio Grüber (2019)
10.1097/FPC.0b013e328330a3b8
Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population
W. Tassaneeyakul (2009)
10.1179/acb.2009.090
DRUG HYPERSENSITIVITY
Nikhil Yawalkar (2009)
10.2217/pgs-2019-0085
Pharmacogenetics and the treatment of epilepsy: what do we know?
N. Božina (2019)
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