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Symptoms At Presentation For Treatment In Patients With Lung Cancer: Implications For The Evaluation Of Palliative Treatment. The Medical Research Council (MRC) Lung Cancer Working Party.

P. Hopwood, R. Stephens
Published 1995 · Medicine

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The ten most frequently reported pretreatment symptoms on the Rotterdam Symptom Checklist, which was completed by more than 650 patients entering two MRC Lung Cancer Working Party multicentre randomised trials, included general symptoms (tiredness, lack of appetite) and psychological distress (worry, anxiety) in addition to disease-related chest symptoms (cough, shortness of breath). Although the number and severity of symptoms increased with worsening performance status, the commonest symptoms were found to be virtually the same for patients with small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC), and for different grades of performance status. Women with NSCLC reported more psychological symptoms than males, but this difference was much less evident in patients with SCLC. Thus, in order to assess fully the benefit of palliative treatments in patients with lung cancer, account must be taken of all symptoms at presentation, in addition to the traditionally recognised chest symptoms.
This paper references
10.1200/JCO.1985.3.4.462
Risk-benefit relationships in cancer clinical trials: the ECOG experience in non-small-cell lung cancer.
R. Simes (1985)
Lessons learned from measuring health-related quality of life in oncology.
C. Hürny (1994)
Quality of Life as Assessed by the Rotterdwn Symptoms Checklist in Patients with Lung Cancer
L Frith (1992)
10.1177/026921639200600406
Symptoms of lung cancer
R. Krech (1992)
10.1038/bjc.1988.219
Mitomycin, ifosfamide and cis-platin in non-small cell lung cancer: treatment good enough to compare.
M. Cullen (1988)
10.1177/082585979100700205
Common Symptoms in Patients with Advanced Cancer
E. B. Curtis (1991)
10.1200/JCO.1984.2.5.472
Measuring the quality of life of cancer patients: the Functional Living Index-Cancer: development and validation.
H. Schipper (1984)
10.1136/thx.48.4.339
Palliation of symptoms in non-small cell lung cancer: a study by the Yorkshire Regional Cancer Organisation Thoracic Group.
M. Muers (1993)
Randomised trial of two radiotherapy ( RT ) policies for patients with inoperable non - small cell lung cancer ( NSCLC ) and good performance status
P MINET
10.1002/1097-0142(19840501)53:9<2002::AID-CNCR2820530933>3.0.CO;2-W
The Karnofsky performance status scale: An examination of its reliability and validity in a research setting
V. Mor (1984)
10.1002/1097-0142(19871115)60:10<2382::AID-CNCR2820601006>3.0.CO;2-V
Ifosfamide, etoposide, and thoracic irradiation therapy in 163 patients with unresectable small cell lung cancer
N. Thatcher (1987)
10.3109/02841868909111177
Quality of life during chemotherapy in non-small cell lung cancer patients.
C. Fernández (1989)
10.1080/09699260.1993.11746662
Symptom evaluation in cancer care
A. Vainio (1993)
Quality of life : clinical judgement versus self - report measures
S KAASA (1992)
10.1016/0959-8049(93)90052-H
Biological, physical, mental and social dimensions of breast cancer: information based on routine case notes.
K. Holli (1993)
10.1038/bjc.1991.351
A randomised trial of planned versus as required chemotherapy in small cell lung cancer: a Cancer Research Campaign trial.
H. Earl (1991)
10.1016/0959-8049(92)90447-A
Doxorubicin in advanced breast cancer: influence of schedule on response, survival and quality of life.
M. Richards (1992)
10.1016/0277-5379(90)90022-L
Quality of life during chemotherapy for small cell lung cancer: assessment and use of a daily diary card in a randomized trial.
D. Geddes (1990)
etoposide and thoracic irradiation therapy in 163 patients with unresectable small cell lung cancer
Ifosfamide
10.1016/S0167-8140(87)80245-1
Quality of life of inoperable non-small cell lung carcinoma. A randomized phase II clinical study comparing radiotherapy alone and combined radio-chemotherapy.
P. Minet (1987)



This paper is referenced by
10.1159/000350834
Lung Cancer Stigma, Anxiety, Depression and Symptom Severity
J. Cataldo (2013)
10.1007/978-3-642-18698-1_35
Symptomatic Treatment in Lung Cancer
M. Muers (2004)
10.1188/04.ONF.203-212
Symptom clusters in elderly patients with lung cancer.
A. Gift (2004)
10.1177/1049909111426135
Quality of Life in Patients With Advanced Lung Cancer Treated at Home and at a Palliative Care Unit
W. Leppert (2012)
10.22034/APJCP.2016.17.11.5041
Thoracic Re-irradiation for Locally Recurrent Lung Cancer
M. Aktan (2016)
The patient with cancer-related dyspnea.
M. Joyce (2009)
10.1007/s00520-007-0301-4
Why patients with lung cancer do not want help with some needs
R. Steele (2007)
10.1016/j.soncn.2007.11.013
Supportive care in lung cancer.
M. Joyce (2008)
10.1056/NEJMoa1000678
Early palliative care for patients with metastatic non-small-cell lung cancer.
J. Temel (2010)
10.1200/JCO.2000.18.2.395
Improving survival without reducing quality of life in small-cell lung cancer patients by increasing the dose-intensity of chemotherapy with granulocyte colony-stimulating factor support: results of a British Medical Research Council Multicenter Randomized Trial. Medical Research Council Lung Cancer
N. Thatcher (2000)
10.1007/s005200000162
A model of palliative care: the palliative medicine program of the Cleveland Clinic Foundation
D. Zhukovsky (2000)
10.1007/s00520-018-4632-0
Assessment of baseline symptom burden in treatment-naïve patients with lung cancer: an observational study
T. Mendoza (2019)
10.5209/REV_PSIC.2006.V3.N2.16703
ASPECTOS PSICOSOCIALES DEL CNCER DE PULMN
A. Krikorian (2006)
10.3816/CLC.2006.N.001
Comprehensive symptom management in patients with advanced-stage non-small-cell lung cancer.
J. Temel (2006)
10.3779/j.issn.1009-3419.2009.05.018
End of life experience of symptom cluster and their management in Hong Kong chinese patients with lung cancer who receive palliative radiotherapy.
C. Chan (2009)
10.1016/S0360-3016(02)02989-9
Randomized phase III trial of single versus fractionated thoracic radiation in the palliation of patients with lung cancer (NCIC CTG SC.15).
A. Bezjak (2002)
10.1586/14737167.4.2.215
Quality of life issues in non-small cell lung cancer
R. Stephens (2004)
10.1007/978-3-319-15678-1_29
Application of Photodynamic Treatment
T. Núñez (2015)
10.1038/bjc.1996.71
Randomised trial of four-drug vs less intensive two-drug chemotherapy in the palliative treatment of patients with small cell lung cancer (SCLC) and poor prognosis
N. Bleehen (1996)
10.4172/2161-0495.1000403
First-Principles Calculations of the Adsorption Property of C6H7N and C7H9N on Pd-doped TiO2 Anatase (1 0 1)
Yingang Gui (2019)
10.1111/ecc.12402
A randomised assessment of the use of a quality of life questionnaire with or without intervention in patients attending a thoracic cancer clinic
K. Nimako (2017)
10.1007/s00520-014-2235-y
The impact of radiotherapy on quality of life for cancer patients: a longitudinal study
B. Yucel (2014)
10.1002/PON.694
Symptom prevalence, distress, and change over time in adults receiving treatment for lung cancer
M. Cooley (2003)
10.1080/09589236.2012.708828
Sexual activity and body image: Examining gender variability and the influence of psychological distress in cancer patients
Jessica L. Krok (2013)
10.2147/LCTT.S14426
Dyspnea in lung cancer patients: a systematic review.
G. Kathiresan (2010)
10.1111/j.1524-4741.2008.00567.x
Clinical Interpretation of Quality‐of‐Life Outcomes: An Investigation of Data from the Randomized Trial of Gemcitabine Plus Paclitaxel Compared with Paclitaxel Alone for Advanced Breast Cancer
P. Hopwood (2008)
10.1177/104990910302000213
A prospective study of the pathophysiology and clinical characteristics of pain in a palliative medicine population
Terence l. Gutgsell (2003)
10.1016/J.JPAINSYMMAN.2003.11.012
Symptom experience in Korean adults with lung cancer.
Eui-Geum Oh (2004)
10.1200/JCO.2006.05.8073
Symptom improvement in lung cancer patients treated with erlotinib: quality of life analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21.
A. Bezjak (2006)
10.1007/978-3-662-46202-7_2
Oncological and Palliative Care for Patients with Lung Cancer and Patients with Breast Cancer: Two Opposite Ends of a Spectrum
Norbert Frickhofen (2015)
10.1016/J.SONCN.2007.01.003
Symptom clusters related to specific cancers.
A. Gift (2007)
10.3816/CLC.2002.N.022
The validity and clinical utility of symptom monitoring in advanced lung cancer: a literature review.
M. Soni (2002)
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