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RPA-coated Single-stranded DNA As A Platform For Post-translational Modifications In The DNA Damage Response
A. Maréchal, L. Zou
Published 2015 · Biology, Medicine
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The Replication Protein A (RPA) complex is an essential regulator of eukaryotic DNA metabolism. RPA avidly binds to single-stranded DNA (ssDNA) through multiple oligonucleotide/oligosaccharide-binding folds and coordinates the recruitment and exchange of genome maintenance factors to regulate DNA replication, recombination and repair. The RPA-ssDNA platform also constitutes a key physiological signal which activates the master ATR kinase to protect and repair stalled or collapsed replication forks during replication stress. In recent years, the RPA complex has emerged as a key target and an important regulator of post-translational modifications in response to DNA damage, which is critical for its genome guardian functions. Phosphorylation and SUMOylation of the RPA complex, and more recently RPA-regulated ubiquitination, have all been shown to control specific aspects of DNA damage signaling and repair by modulating the interactions between RPA and its partners. Here, we review our current understanding of the critical functions of the RPA-ssDNA platform in the maintenance of genome stability and its regulation through an elaborate network of covalent modifications.
This paper references
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.
Y. Galanty (2012)
Recruitment of Replication Protein A by the Papillomavirus E1 Protein and Modulation by Single-Stranded DNA
Y. Loo (2004)
Structural mechanism of RPA loading on DNA during activation of a simple pre‐replication complex
X. Jiang (2006)
Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase.
Z. Q. Pan (1994)
Formation of a Complex between Nucleolin and Replication Protein a after Cell Stress Prevents Initiation of DNA Replication
Y. Daniely (2000)
The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement
Keziban Ünsal-Kaçmaz (2007)
Functional Analysis of the Four DNA Binding Domains of Replication Protein A
S. Bastin-Shanower (2001)
Replication‐mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA‐dependent protein kinase and dissociates RPA:DNA‐PK complexes
R. Shao (1999)
Structure of the RPA trimerization core and its role in the multistep DNA‐binding mechanism of RPA
E. Bochkareva (2002)
Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing
C. Lucca (2004)
Functional Analysis of Human Replication Protein A in Nucleotide Excision Repair*
E. Stigger (1998)
Identification and Characterization of the Fourth Single-Stranded-DNA Binding Domain of Replication Protein A
S. Brill (1998)
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM.
H. Y. Yoo (2009)
Role of interaction of XPF with RPA in nucleotide excision repair.
L. Fisher (2011)
TopBP1 Activates the ATR-ATRIP Complex
A. Kumagai (2006)
Structural Basis for the Recognition of DNA Repair Proteins UNG2, XPA, and RAD52 by Replication Factor RPA
G. Mer (2000)
Proteolytic mapping of human replication protein A: evidence for multiple structural domains and a conformational change upon interaction with single-stranded DNA.
X. Gomes (1996)
Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage
H. Shima (2013)
Sumoylation of MDC1 is important for proper DNA damage response
K. Luo (2012)
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro
S. Waga (1994)
Multiple competition reactions for RPA order the assembly of the DNA polymerase δ holoenzyme
A. Yuzhakov (1999)
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest.
A. Pellicioli (2001)
The DNA damage response: making it safe to play with knives.
Alberto Ciccia (2010)
Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA
V. Ellison (2003)
Chemical shift changes provide evidence for overlapping single-stranded DNA- and XPA-binding sites on the 70 kDa subunit of human replication protein A.
G. Daughdrill (2003)
Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells.
S. Din (1990)
Inhibition of DNA replication factor RPA by p53
A. Dutta (1993)
Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage
S. Lee (1998)
Phosphorylation of the Budding Yeast 9-1-1 Complex Is Required for Dpb11 Function in the Full Activation of the UV-Induced DNA Damage Checkpoint
Fabio Puddu (2008)
Mechanisms and functions of DNA mismatch repair
G. Li (2008)
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.
S. Delacroix (2007)
The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling
X. Xu (2008)
The Phosphorylation Domain of the 32-kDa Subunit of Replication Protein A (RPA) Modulates RPA-DNA Interactions
Sara K. Binz (2003)
53 BP 1 is a reader of the DNAdamageinduced H 2 A Lys 15 ubiquitin mark
A Fradet-Turcotte (2013)
The Mre11 Complex Mediates the S-Phase Checkpoint through an Interaction with Replication Protein A
E. Olson (2007)
53BP1 is a reader of the DNA damage-induced H2A Lys15 ubiquitin mark
Amélie Fradet-Turcotte (2013)
Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA
A. Bochkarev (1997)
Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery
A. Murphy (2014)
DNA repair mechanisms in dividing and non-dividing cells.
T. Iyama (2013)
ATR phosphorylates SMARCAL1 to prevent replication fork collapse.
Frank B Couch (2013)
Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA.
M. Wold (1988)
Replication protein A interactions with DNA. 2. Characterization of double-stranded DNA-binding/helix-destabilization activities and the role of the zinc-finger domain in DNA interactions.
Y. Lao (1999)
Replication protein A phosphorylation and the cellular response to DNA damage.
Sara K. Binz (2004)
The Prp19p-Associated Complex in Spliceosome Activation
S. Chan (2003)
Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle.
F. Fang (1993)
The Pso4 mRNA Splicing and DNA Repair Complex Interacts with WRN for Processing of DNA Interstrand Cross-links*
N. Zhang (2005)
DNA damage sensing by the ATM and ATR kinases.
A. Maréchal (2013)
cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication.
A. Dutta (1992)
The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA.
T. Yusufzai (2009)
Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint.
Catherine A. Cremona (2012)
Local and global functions of Timeless and Tipin in replication fork protection
A. R. Leman (2012)
53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage
Eunjae Yoo (2005)
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress*
M. Kemp (2010)
DNA structure-specific priming of ATR activation by DNA-PKcs
Sophie Vidal-Eychenié (2013)
Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism.
K. Umezu (1998)
Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic Advancement
B. Lok (2012)
Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
E. Bochkareva (2005)
The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR*
J. Lee (2007)
Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression.
Zhigang Guo (2012)
Roles of replication protein-A subunits 2 and 3 in DNA replication fork movement in Saccharomyces cerevisiae.
H. Maniar (1997)
Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner.
N. A. Abramova (1997)
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
Daniel A. Mordes (2008)
Regulatory Functions of the N-terminal Domain of the 70-kDa Subunit of Replication Protein A (RPA)*
Sara K. Binz (2008)
An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair.
L. Li (1995)
DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair.
W. de Laat (1998)
Sequential and Synergistic Modification of Human RPA Stimulates Chromosomal DNA Repair*
R. W. Anantha (2007)
Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians
R. L. Flynn (2010)
Physical and Functional Mapping of the Replication Protein A Interaction Domain of the Werner and Bloom Syndrome Helicases*
K. Doherty (2005)
Human Exonuclease 5 Is a Novel Sliding Exonuclease Required for Genome Stability*
Justin L. Sparks (2012)
Replication Protein A and the Mre11·Rad50·Nbs1 Complex Co-localize and Interact at Sites of Stalled Replication Forks*
J. Robison (2004)
The role of RPA2 phosphorylation in homologous recombination in response to replication arrest.
W. Shi (2010)
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
A. Maréchal (2014)
The annealing helicase HARP protects stalled replication forks.
J. Yuan (2009)
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.
E. J. Song (2010)
Molecular Cooperation between the Werner Syndrome Protein and Replication Protein A in Relation to Replication Fork Blockage*
A. Machwe (2010)
Cellular Functions of Human RPA1
S. Haring (2008)
Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts
A. Errico (2007)
Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres
Amra Grudic (2007)
Physical Interaction between Replication Protein A and Rad51 Promotes Exchange on Single-stranded DNA*
Melissa E Stauffer (2004)
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.
Alberto Ciccia (2009)
Base excision repair.
H. Krokan (2013)
Replication protein A interactions with DNA. III. Molecular basis of recognition of damaged DNA.
Y. Lao (2000)
Molecular Architecture of the Human Prp19/CDC5L Complex
M. Grote (2010)
The Slx5-Slx8 Complex Affects Sumoylation of DNA Repair Proteins and Negatively Regulates Recombination
R. Burgess (2007)
Replication protein A-mediated recruitment and activation of Rad17 complexes
L. Zou (2003)
Studies of the Interaction between Rad52 Protein and the Yeast Single-Stranded DNA Binding Protein RPA
S. Hays (1998)
DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.
A. Ashley (2014)
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
Shengqin Liu (2012)
Replication Protein A Directs Loading of the DNA Damage Checkpoint Clamp to 5′-DNA Junctions*
J. Majka (2006)
Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitro.
Kwang-Hee Bae (2003)
RING Finger and WD Repeat Domain 3 (RFWD3) Associates with Replication Protein A (RPA) and Facilitates RPA-mediated DNA Damage Response*
S. Liu (2011)
RNF4 is required for DNA double-strand break repair in vivo
R. Vyas (2013)
Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis
H. Stephan (2009)
Replication Protein A Physically Interacts with the Bloom's Syndrome Protein and Stimulates Its Helicase Activity*
R. Brosh (2000)
Identification of SMARCAL1 as a Component of the DNA Damage Response*
L. Postow (2009)
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.
Stéphanie Panier (2012)
Premature aging and cancer in nucleotide excision repair-disorders.
K. Diderich (2011)
Nucleotide Excision Repair by Mutant Xeroderma Pigmentosum Group A (XPA) Proteins with Deficiency in Interaction with RPA*
M. Saijo (2010)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
L. Povlsen (2012)
Cellular factors required for multiple stages of SV40 DNA replication in vitro.
M. Fairman (1988)
Replication protein A interactions with DNA: differential binding of the core domains and analysis of the DNA interaction surface.
Iwona M Wyka (2003)
RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage
R. W. Anantha (2008)
RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions.
Gregory G. Oakley (2003)
Human CtIP promotes DNA end resection
A. A. Sartori (2007)
RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes
Sung-Ho Bae (2001)
Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
Xiaoming Wu (2005)
FANCJ ( BACH 1 ) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein
R. Gupta (2007)
Functional and Physical Interaction between WRN Helicase and Human Replication Protein A*
R. Brosh (1999)
Biochemical characterisation of the SWI/SNF family member HLTF.
C. Mackay (2009)
Interactions of human replication protein A with oligonucleotides.
C. Kim (1994)
Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A
A. Davies (2008)
E3 Ligase RFWD3 Participates in Replication Checkpoint Control*
Zihua Gong (2011)
A dynamic model for replication protein A (RPA) function in DNA processing pathways
E. Fanning (2006)
Replication protein A: directing traffic at the intersection of replication and repair.
G. Oakley (2010)
SUMO‐targeted ubiquitin ligases in genome stability
J. Prudden (2007)
Dpb11 activates the Mec1–Ddc2 complex
Daniel A. Mordes (2008)
Structure and conformational change of a replication protein A heterotrimer bound to ssDNA.
J. Fan (2012)
Regulation of DNA damage responses by ubiquitin and SUMO.
S. Jackson (2013)
RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint*
E. Olson (2006)
Reconstitution of Human Excision Nuclease with Recombinant XPF-ERCC1 Complex*
T. Bessho (1997)
Physical Interaction between Human RAD52 and RPA Is Required for Homologous Recombination in Mammalian Cells*
M. S. Park (1996)
The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition.
A. VanDemark (2006)
Formation of a complex
Y Daniely (2008)
hPrimpol1/CCDC111 is a human DNA primase‐polymerase required for the maintenance of genome integrity
L. Wan (2013)
The PSO4 Protein Complex Associates with Replication Protein A (RPA) and Modulates the Activation of Ataxia Telangiectasia-mutated and Rad3-related (ATR)*
L. Wan (2014)
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
Z. He (1995)
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase
Mardo Kõivomägi (2011)
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.
Carol E. Bansbach (2009)
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response
H. Reinhardt (2013)
ATR autophosphorylation as a molecular switch for checkpoint activation.
Shizhou Liu (2011)
Solution structure of the DNA-binding domain of RPA from Saccharomyces cerevisiae and its interaction with single-stranded DNA and SV40 T antigen
Chin-Ju Park (2005)
Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair
Ivan Psakhye (2012)
Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1.
G. Oakley (2009)
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
D. Lee (2010)
UV light‐induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single‐stranded DNA‐binding protein.
M. Carty (1994)
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
J. Chaudhuri (2004)
Independent and Coordinated Functions of Replication Protein A Tandem High Affinity Single-stranded DNA Binding Domains*
A. I. Arunkumar (2003)
Species specificity of human RPA in simian virus 40 DNA replication lies in T-antigen-dependent RNA primer synthesis.
M. Wang (2000)
Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase*
Vasundhara M Navadgi-Patil (2008)
Homologous recombination and its regulation
L. Krejci (2012)
Structure of the major single‐stranded DNA‐binding domain of replication protein A suggests a dynamic mechanism for DNA binding
E. Bochkareva (2001)
Human replication protein A: Global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linker†
D. M. Jacobs (1999)
RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage
Catherine M. Guzzo (2012)
Protein Phosphatase 2A-Dependent Dephosphorylation of Replication Protein A Is Required for the Repair of DNA Breaks Induced by Replication Stress
J. Feng (2009)
Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks
J. Lee (2010)
Cdc5L interacts with ATR and is required for the S‐phase cell‐cycle checkpoint
N. Zhang (2009)
Biochemical characterization of DNA
V Ellison (2013)
Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2
J. Wong (2003)
The Role of the Human Psoralen 4 (hPso4) Protein Complex in Replication Stress and Homologous Recombination*
M. Abbas (2014)
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation
A. N. Kousholt (2012)
The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different co-factor requirements.
L. Wang (1995)
Insights into hRPA32 C-terminal domain–mediated assembly of the simian virus 40 replisome
A. I. Arunkumar (2005)
Mutations in the gene encoding the 34 kDa subunit of yeast replication protein A cause defective S phase progression.
C. Santocanale (1995)
The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication
R. Li (1993)
SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage.
Yili Yin (2012)
Physical interaction between DCA1 and DST.
Cui Long-Gang (2015)
RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT.
M. Fujimoto (2012)
Replication of simian virus 40 origin-containing DNA in vitro with purified proteins.
C. Wobbe (1987)
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
L. Zou (2003)
Human Pso4 Is a Metnase (SETMAR)-binding Partner That Regulates Metnase Function in DNA Repair*
B. D. Beck (2008)
Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress
V. M. Vassin (2009)
The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells.
V. Liu (1993)
Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase
K. N. Mahajan (2003)
RPA governs endonu
SH Bae (2010)
Rfc4 Interacts with Rpa1 and Is Required for Both DNA Replication and DNA Damage Checkpoints in Saccharomyces cerevisiae
H. S. Kim (2001)
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity
Jiang-Cheng Shen (2003)
Replication Protein A (RPA) Phosphorylation Prevents RPA Association with Replication Centers
V. M. Vassin (2004)
Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.
H. Dou (2010)
Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replication
S. Brill (1989)
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
W. Block (2004)
BID Binds to Replication Protein A and Stimulates ATR Function following Replicative Stress
Y. Liu (2011)
Enzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2
D. Kim (2005)
A Sequence in the N-terminal Region of Human Uracil-DNA Glycosylase with Homology to XPA Interacts with the C-terminal Part of the 34-kDa Subunit of Replication Protein A*
T. A. Nagelhus (1997)
Cell cycle regulated phosphorylation of RPA‐32 occurs within the replication initiation complex.
R. Fotedar (1992)
DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair.
S. M. Patrick (2005)
Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.
B. Shiotani (2013)
Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage.
Xiaoming Wu (2005)
Sites of UV-induced Phosphorylation of the p34 Subunit of Replication Protein A from HeLa Cells*
M. Zernik-Kobak (1997)
The Role of the 34-kDa Subunit of Human Replication Protein A in Simian Virus 40 DNA Replication in Vitro(*)
S. Lee (1995)
A DYNAMIC MODEL
OBERTO E SPOSTI (2000)
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications.
Sophie E Polo (2011)
RPA regulates telomerase action by providing Est1p access to chromosome ends
V. Schramke (2004)
Replication Protein A Confers Structure-specific Endonuclease Activities to the XPF-ERCC1 and XPG Subunits of Human DNA Repair Excision Nuclease (*)
T. Matsunaga (1996)
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
L. Toledo (2013)
Interaction of DNA polymerase alpha‐primase with cellular replication protein A and SV40 T antigen.
I. Dornreiter (1992)
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
Yeon-Tae Jeong (2013)
ATR: an essential regulator of genome integrity
K. Cimprich (2008)
C MacKay (2007)
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism.
M. Wold (1997)
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair
M. Serrano (2013)
DNA-PK-Dependent RPA2 Hyperphosphorylation Facilitates DNA Repair and Suppresses Sister Chromatid Exchange
H. Liaw (2011)
Human replication protein A binds single-stranded DNA in two distinct complexes.
L. J. Blackwell (1994)
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
R. Gupta (2007)
This paper is referenced by
Identificación del factor de splicing SLU7 como controlador de la estabilidad genómica
Maddalen Jiménez Andrés (2019)
Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress
Stephanie M Ackerson (2020)
Biochemical and Functional Characterization of Rpa2 N-Terminal Phosphorylation during DNA Repair and Checkpoint Adaptation in Saccharomyces Cerevisiae
Timothy M Wilson (2018)
Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
N. Bigot (2019)
Controlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMO
Sarah-Felicitas Himmels (2016)
TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication.
Xin Nie (2020)
HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.
Wenwen Wu (2018)
PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors
L. A. Parsels (2017)
Human CST complex protects replication fork stability by directly blocking MRE11 degradation of nascent strand DNA
Xinxing Lyu (2019)
The Shieldin complex mediates 53BP1-dependent DNA repair
S. M. Noordermeer (2018)
Regulation of resection by chromatin associated proteins
F. Navarro (2019)
RPA binds histone H3-H4 and functions in DNA replication–coupled nucleosome assembly
Shaofeng Liu (2017)
Analysis of uracil DNA glycosylase (UNG2) stimulation by replication protein A (RPA) at ssDNA-dsDNA junctions.
B. Weiser (2019)
G9a coordinates with the RPA complex to promote DNA damage repair and cell survival
Qiaoyan Yang (2017)
RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR
Ke Lyu (2019)
Nontranscriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis
H. Daitoku (2016)
Characterizing the Combination of RPA Inhibitors with PARP Inhibitors in High-Grade Serous Ovarian Cancer
Y. Tang (2019)
Replication protein A (RPA) sumoylation positively influences the DNA damage checkpoint response in yeast
Nalini Dhingra (2018)
Selective antitumor activity of roscovitine in head and neck cancer
Cyril S. Gary (2016)
RPA Phosphorylation Inhibits DNA Resection.
Michael M. Soniat (2019)
Chaperoning RPA during DNA metabolism
Shuqi Li (2019)
Ubiquitination — An Evolving Role in DNA Repair
E. Boutou (2015)
Yeast genome-wide telomere screens and insights into cancer
P. Rodrigues (2017)
Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
H. B. Landsverk (2019)
New mechanisms involved in the DNA replication stress response of non-transformed human cells
Amaia Ercilla Eguiarte (2016)
Strand Displacement Activity of PrimPol
E. O. Boldinova (2020)
Human single-stranded DNA binding proteins: guardians of genome stability.
Y. Wu (2016)
Regulation of ATR activity by the RNA polymerase II phosphatase PNUTS-PP1
H. B. Landsverk (2018)
Mammalian CST averts replication failure by preventing G-quadruplex accumulation
Yang Liu (2018)
Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome
Lucy Glover (2019)
The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia
Pauline Rimmelé (2017)
ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response.
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