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Glucose Metabolic Rate Kinetic Model Parameter Determination In Humans: The Lumped Constants And Rate Constants For [18F]Fluorodeoxyglucose And [11C]Deoxyglucose

M. Reivich, A. Alavi, A. Wolf, J. Fowler, J. Russell, C. Arnett, R. Macgregor, C. Shiue, H. Atkins, A. Anand, R. Dann, J. Greenberg
Published 1985 · Chemistry, Medicine

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The rate constants and lumped constants (LCs) for [18F]fluorodeoxyglucose ([18F]FDG) and [11C]deoxyglucose ([11C]DG) were determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption. The mean values (±SE) of the LCs for [18F]FDG and [11C]DG are 0.52 ± 0.028 (n = 9) and 0.56 ± 0.043 (n = 6), respectively. The mean values (±SE) of the rate constants k*1, k*2, k*3, and k*4 for [18F]FDG for gray matter are 0.095 ± 0.005, 0.125 ± 0.002, 0.069 ± 0.002, and 0.0055 ± 0.0003, respectively. The corresponding values for white matter are 0.065 ± 0.005, 0.126 ± 0.003, 0.066 ± 0.002, and 0.0054 ± 0.0006, respectively. Using these values and previously published values for the rate constants for [11C]DG, the average whole-brain metabolic rates for glucose in normal subjects measured with [18F]FDG and [11C]DG are 5.66 ± 0.37 (n = 6) and 4.99 ± 0.23 (n = 6) mg/100 g/min, respectively. These values are not significantly different (t = 1.56, p > 0.10) and agree well with reported values in the literature determined by means of the Kety-Schmidt technique.
This paper references
10.1148/114.1.89
A positron-emission transaxial tomograph for nuclear imaging (PETT).
M. Ter-Pogossian (1975)
Measurement of local cerebral glucose me ­ tabolism in man with 1 8 F - 2 - fluoro - 2 - deoxY - D - glucose
M Reivich
The [ 14 Cldeoxyglucose method for the measurement of local ce ­ rebral glucose utilization : theory , procedure and normal values in the conscious and anesthetized albino rat
V Synek
10.1016/0024-3205(81)90657-3
Metabolism of [14C]fluorodeoxyglucose by rat brain in vivo.
A. Miller (1981)
10.1002/ANA.410060502
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method
M. Phelps (1979)
10.1002/JLCR.2580140204
Labeled 2-deoxy-D-glucose analogs. 18F-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose
T. Ido (1978)
Measurement of local cerebral glucose metabolism in man with 18F-2-fluoro-2-deoxy-d-glucose.
M. Reivich (1977)
10.1152/JAPPL.1967.23.2.183
Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man.
P. Cohen (1967)
10.1093/COMJNL/6.2.163
A Rapidly Convergent Descent Method for Minimization
R. Fletcher (1963)
10.1152/AJPLEGACY.1970.219.5.1505
Sugar transport across the blood-brain barrier.
P. M. Buschiazzo (1970)
10.1152/AJPLEGACY.1973.225.3.586
Kinetics of unidirectional glucose transport into the isolated dog brain.
A. Betz (1973)
10.1016/B978-0-12-027310-2.50010-4
Positron emission tomographic studies of local cerebral glucose metabolism in humans in physiological and pathophysiological conditions.
M. Reivich (1983)
10.1111/j.1471-4159.1977.tb10649.x
THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
L. Sokoloff (1977)
Development of a sensitive radioassay of histamine for in vitro allergy testing.
B. Faraj (1984)
Noninvasive determination of local cerebral met ­ abolic rate of glucose in man
EJ Hoffman
Metabolic mapping of func ­ tional activity in human subjects with the [ 1 8 F ] fluoro ­ deoxyglucose technique
JH Greenberg
A synthesis of 2-deoxy-D-[1-11C]glucose for regional metabolic studies: concise communication.
R. Macgregor (1981)
10.1152/JAPPL.1976.40.3.458
A method to obtain infusion schedules for prescribed blood concentration time courses.
C. Patlak (1976)
10.1152/AJPLEGACY.1971.220.5.1182
Mediated transport of glucose between blood and brain in the cat.
R. Cutler (1971)
Metter J ( 1 98 1 ) Local cerebral glucose metabolism in Huntington ' s disease determined by e m i s s ion computed tomography of [ 1 8 F ] fluorodeoxyglucose
DE Kuhl
Epileptic pat ­ terns of local cerebral metabolism and perfusion in humans determined by emiss ion computed tomography of 1 8 FDG and 1 3 NHJ
DE Kuhl
10.1172/JCI101994
THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES.
S. Kety (1948)
10.1038/jcbfm.1982.32
Use of 2-Deoxy-D[1-11C]Glucose for the Determination of Local Cerebral Glucose Metabolism in Humans: Variation within and between Subjects
M. Reivich (1982)
10.1210/ENDO-82-1-1
Effect of insulin on the synthesis of glycogen in cerebral cortical slices of alloxan diabetic rats.
K. Prasannan (1968)
10.1001/ARCHNEUR.1983.04050110033004
Quantitative computed tomographic analysis in the diagnosis of dementia.
H. Damasio (1983)
10.1136/jnnp.47.8.824
Local cerebral glucose utilisation in treated and untreated patients with Parkinson's disease.
D. Rougemont (1984)
10.1097/00004728-198012000-00033
EFFECTS OF STROKE ON LOCAL CEREBRAL METABOLISM AND PERFUSION: MAPPING BY EMISSION COMPUTED TOMOGRAPHY OF 18FDG AND 13NH3
D. Kuhl (1980)
Metter J ( 1 98 1 ) Local cerebral glucose metabolism in Huntington ' s disease determined by e m i s s ion computed tomography of [ 1 8 F ] fluorodeoxyglucose
DE Kuhl
10.1097/00004728-198012000-00032
TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC RATE IN HUMANS WITH (F‐18)2‐FLUORO-2‐DEOXY-D‐GLUCOSE: VALIDATION OF METHOD
M. Phelps (1979)
10.1097/00004728-197811000-00002
Design considerations for a positron emission transverse tomograph (PETT V) for imaging of the brain.
M. Ter-Pogossian (1978)
10.1126/SCIENCE.6970412
Metabolic mapping of the brain's response to visual stimulation: studies in humans
M. Phelps (1981)
10.1007/BF01478536
[THE CARBOHYDRATE METABOLISM OF THE HUMAN BRAIN. I. STUDIES WITH SUBSTRATE-SPECIFIC ENZYMATIC METHODS IN NORMAL BRAIN CIRCULATION].
U. Gottstein (1963)
The [ 1 8 Flfluorodeoxyglucose method for the mea ­ surement of local cerebral glucose utilization in man
M Reivich (1982)
PET measurements of cerebral metabolism corrected for CSF contributions
J. Chawluk (1984)
Der Kohlen ­ hydratstoffwechsel des menschichen Gehirns . 1 . Untersu ­ chungen mit substratspezifischen enzymatischen Methoden bei normaler Hirndurchblutung
U Gottstein
10.1259/0007-1285-49-579-233
The ventricular-brain ratio using planimetric measurement of EMI scans.
V. Synek (1976)
Epileptic pat ­ terns of local cerebral metabolism and perfusion in humans determined by emiss ion computed tomography of 1 8 FDG and 1 3 NHJ
DE Kuhl
10.1126/SCIENCE.6971492
Metabolic mapping of functional activity in human subjects with the [18F]fluorodeoxyglucose technique.
J. Greenberg (1981)
10.1161/01.RES.44.1.127
The [18F]Fluorodeoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization in Mane
M. Reivich (1979)
10.3181/00379727-105-26150
Glucose-6-Phosphatase Activity in Various Sheep Tissues.∗
F. Raggi (1960)
10.1148/RADIOLOGY.149.2.6622694
Ventricular volume and cognitive deficit: a computed tomographic study.
A. George (1983)
10.1097/00000542-197201000-00013
The Effects of Ketamine on Cerebral Circulation and Metabolism in Man
H. Takeshita (1972)
Alavi A ( 1 98 3 ) Positron emiss ion tomographic studies of local cerebral glucose metabolism in humans in phys iological and pathophysiological conditions
M Reivich
10.1152/AJPENDO.1980.238.1.E69
Noninvasive determination of local cerebral metabolic rate of glucose in man.
S. Huang (1980)
The [ 1 8 Flfluorodeoxyglucose method for the mea ­ surement of local cerebral glucose utilization in man
M Reivich (1982)
Fluorination in aqueous media with elemental fluorine: The synthesis of (F-18)2-FDG
G. Bida (1984)
10.1002/CHIN.198445150
A PREPARATIVE GAS-SOLID-PHASE SYNTHESIS OF ACETYL HYPOFLUORITE
D. Jewett (1984)
10.1039/C29690000309
2-Deoxy-2-fluoro-D-glucose
J. Adamson (1969)
10.1111/j.1471-4159.1983.tb12666.x
Kinetics of Transport and Phosphorylation of 2‐Fluoro‐2‐Deoxy‐d‐Glucose in Rat Brain
P. Crane (1983)
10.1172/JCI102150
The cerebral blood flow in male subjects as measured by the nitrous oxide technique; normal values for blood flow, oxygen utilization, glucose utilization and peripheral resistance, with observations on the effect of tilting and anxiety.
P. Cheinberg (1949)
10.1038/jcbfm.1984.30
Regional Kinetic Constants and Cerebral Metabolic Rate for Glucose in Normal Human Volunteers Determined by Dynamic Positron Emission Tomography of [18F]-2-Fluoro-2-Deoxy-D-Glucose
W. Heiss (1984)
10.1152/AJPLEGACY.1971.220.3.841
Blood-brain transfer of glucose and other molecules measured by rapid indicator dilution.
D. Yudilevich (1971)
( 1 98 1 ) A synthesis of 2 - deoxY - D - [ I - I I C ] glucose for re ­ gional metabolism studie s : concise communication
O Lowry
Volumetric correction of cerebral metabolic rates in dementia and normal aging [ Abstract ]
J Chawluk
10.1111/j.1365-2990.1980.tb00283.x
VARIATION WITH AGE IN THE VOLUMES OF GREY AND WHITE MATTER IN THE CEREBRAL HEMISPHERES OF MAN: MEASUREMENTS WITH AN IMAGE ANALYSER
A. K. Miller (1980)
Regional cerebral metabolic alterations in Alzheimer - type dementia : kinetic studies with 1 8 - fluorodeoxyglucose
RP Friedland
10.1002/ANA.410080108
Effects of stroke on local cerebral metabolism and perfusion: Mapping by emission computed tomography of 18FDG and 13NH3
D. Kuhl (1980)
THE CEREBRAL BLOOD FLOW IN MALE SUBJECTS AS MEASURED BY THE NITROUS OXIDE TECHNIQUE. NORMAL VALUES FOR BLOOD FLOW, OXYGEN UTILIZATION, GLUCOSE UTILIZATION, AND PERIPHERAL RESISTANCE, WITH OBSERVATIONS ON THE EFFECT OF TILTING AND ANXIETY.
P. Scheinberg (1949)
10.1148/RADIOLOGY.144.3.7100467
Volumetric measurements of the cerebrospinal fluid spaces in demented subjects and controls.
M. Gado (1982)
A rapid descent method for min ­ imization
R Fletcher
10.1002/ANA.410080403
Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of 18FDG and 13NH3
D. Kuhl (1980)



This paper is referenced by
10.1161/01.STR.30.3.556
Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy.
O. Sabri (1999)
10.1007/s002590050329
Cerebral interregional correlations of associative language processing: a positron emission tomography activation study using fluorine-18 fluorodeoxyglucose
M. Schreckenberger (1998)
10.1093/BRAIN/113.5.1405
Cortical and subcortical glucose consumption measured by PET in patients with Huntington's disease.
T. Kuwert (1990)
10.1001/ARCHNEUR.1992.00530350056020
Topography of cross-sectional and longitudinal glucose metabolic deficits in Alzheimer's disease. Pathophysiologic implications.
G. Smith (1992)
10.1007/978-3-642-57703-1_6
FDG: biochemical concept and radiochemical synthesis
W. Hamkens (2000)
10.1124/JPET.103.050245
Effect of N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate (FK960), an Antidementia Drug with a Novel Mechanism of Action, on Regional Cerebral Blood Flow and Glucose Metabolism in Aged Rhesus Macaques Studied with Positron Emission Tomography
A. Noda (2003)
10.1007/s00259-013-2488-6
A prospective analysis of 18F-FDG PET/CT in patients with uveal melanoma: comparison between metabolic rate of glucose (MRglu) and standardized uptake value (SUV) and correlations with histopathological features
Maria Lucia Calcagni (2013)
10.1016/j.ejrad.2010.12.102
PET/CT and vascular disease: current concepts.
José Leite Gondim Cavalcanti Filho (2011)
10.1088/0031-9155/59/5/1165
Evaluation of radiation dose to anthropomorphic paediatric models from positron-emitting labelled tracers.
T. Xie (2014)
10.1073/pnas.191044198
Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-d-glucose/positron-emission tomography (FDG/PET)
M. de Leon (2001)
10.1053/J.GASTRO.2006.12.040
Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs.
P. Iozzo (2007)
10.1038/oby.2008.469
Inverse Association Between BMI and Prefrontal Metabolic Activity in Healthy Adults
N. Volkow (2009)
10.1016/S0893-133X(96)00098-X
Temporal Lobe Metabolic Differences in Medication-Free Outpatients with Schizophrenia via the PET-600
T. Nordahl (1996)
10.1038/jcbfm.1994.52
The Use of Spectral Analysis to Determine Regional Cerebral Glucose Utilization with Positron Emission Tomography and [18F]Fluorodeoxyglucose: Theory, Implementation, and Optimization Procedures
F. Turkheimer (1994)
10.1177/19714009930060S127
La tomografia ad emissione nella patologia neurodegenerativa
D. Perani (1993)
10.1136/jnnp.59.4.427
Increased interictal cerebral glucose metabolism in a cortical-subcortical network in drug naive patients with cryptogenic temporal lobe epilepsy.
M. Franceschi (1995)
10.1002/ANA.410290521
Altered glucose metabolism in microvessels from patients with Alzheimer's disease
Sami I. Harik (1989)
10.1212/WNL.49.1.126
Cerebral metabolism in fatal familial insomnia: Relation to duration, neuropathology, and distribution of protease-resistent prion protein
P. Cortelli (1997)
10.1007/978-1-4614-1788-0_14
The Coupling of Cerebral Metabolic Rate of Glucose and Cerebral Blood Flow In Vivo
S. Hasselbalch (2012)
10.1007/s00018-015-2079-8
Brain glucose metabolism during hypoglycemia in type 1 diabetes: insights from functional and metabolic neuroimaging studies
Hanne M Rooijackers (2015)
10.1212/WNL.46.5.1422
Topography of interictal glucose hypometabolism in unilateral mesiotemporal epilepsy
S. Arnold (1996)
10.1007/978-0-387-22529-6_4
The Molecular Basis of Disease
J. Barrio (2004)
10.3389/fnins.2018.00631
Trajectories of Brain Lactate and Re-visited Oxygen-Glucose Index Calculations Do Not Support Elevated Non-oxidative Metabolism of Glucose Across Childhood
H. Benveniste (2018)
10.2337/DIABETES.51.12.3384
The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study.
E. Bingham (2002)
10.1016/S0006-8993(02)02558-1
Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys
A. Noda (2002)
10.1038/jcbfm.1994.17
Brain Metabolism during Short-Term Starvation in Humans
S. Hasselbalch (1994)
10.1161/01.STR.30.7.1424
Uncoupling of oxygen and glucose metabolism in persistent crossed cerebellar diaschisis.
H. Yamauchi (1999)
10.1016/0022-510X(95)00293-B
Neurological impairment and recovery in Wilson's disease: evidence from PET and MRI
G. Schlaug (1996)
10.1177/096228029400300105
Statistical methods in neuroimaging with particular application to emission tomography
J. Mccoll (1994)
10.1023/A:1005784020134
Subependymoma of the septum pellucidum: Characterization by PET
K. Mineura (2004)
10.1196/annals.1441.023
Nonhuman Primate Neuroimaging and the Neurobiology of Psychostimulant Addiction
L. Howell (2008)
10.1038/jcbfm.1990.33
Michaelis-Menten Constraints Improved Cerebral Glucose Metabolism and Regional Lumped Constant Measurements with [18F]Fluorodeoxyglucose
H. Kuwabara (1990)
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