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Biodegradable Nanostructures With Selective Lysis Of Microbial Membranes.
F. Nederberg, Y. Zhang, J. Tan, K. Xu, H. Wang, C. Yang, Shujun Gao, Xin Guo, Kazuki Fukushima, L. Li, J. Hedrick, Yi-Yan Yang
Published 2011 · Chemistry, Medicine
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Macromolecular antimicrobial agents such as cationic polymers and peptides have recently been under an increased level of scrutiny because they can combat multi-drug-resistant microbes. Most of these polymers are non-biodegradable and are designed to mimic the facially amphiphilic structure of peptides so that they may form a secondary structure on interaction with negatively charged microbial membranes. The resulting secondary structure can insert into and disintegrate the cell membrane after recruiting additional polymer molecules. Here, we report the first biodegradable and in vivo applicable antimicrobial polymer nanoparticles synthesized by metal-free organocatalytic ring-opening polymerization of functional cyclic carbonate. We demonstrate that the nanoparticles disrupt microbial walls/membranes selectively and efficiently, thus inhibiting the growth of Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and fungi, without inducing significant haemolysis over a wide range of concentrations. These biodegradable nanoparticles, which can be synthesized in large quantities and at low cost, are promising as antimicrobial drugs, and can be used to treat various infectious diseases such as MRSA-associated infections, which are often linked with high mortality.
This paper references
Amphiphilic polymethacrylate derivatives as antimicrobial agents.
K. Kuroda (2005)
Cochlear prostheses. A state-of-the-art review.
J. Tonndorf (1977)
Antibacterial and hemolytic activities of pyridinium polymers as a function of the spatial relationship between the positive charge and the pendant alkyl tail.
V. Sambhy (2008)
a versatile equivalent of (meth)acrylate for ring-opening polymerization
R. C. Pratt (2008)
De novo design of biomimetic antimicrobial polymers
G. Tew (2002)
a molecular construction kit approach
Reflexive Interfaces of Poly(trimethylene carbonate)-Based Polymers: Enzymatic Degradation and Selective Adsorption
J. Watanabe (2007)
Influence of lipid composition on membrane activity of antimicrobial phenylene ethynylene oligomers.
A. Som (2008)
Antimicrobial peptides in mammalian and insect host defence.
R. Lehrer (1999)
Characterization of nonbiological antimicrobial polymers in aqueous solution and at water-lipid interfaces from all-atom molecular dynamics.
I. Ivanov (2006)
Sterilization, storage stability and in vivo biocompatibility of poly(trimethylene carbonate)/poly(adipic anhydride) blends.
U. Edlund (2000)
Cyclization of a cytolytic amphipathic alpha-helical peptide and its diastereomer: effect on structure, interaction with model membranes, and biological function.
Z. Oren (2000)
Organocatalytic ring opening polymerization of trimethylene carbonate.
F. Nederberg (2007)
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
R. Hancock (2006)
effect on structure, interaction with model membranes, and biological function
Z. Oren (2000)
Vancomycin-resistant enterococcal infections.
B. Murray (2000)
structures and mechanisms of action
D. I. Chan (2006)
A Review of Antimicrobial Peptides and Their Therapeutic Potential as Anti-Infective Drugs
Y. J. Gordon (2005)
Synthesis, properties, and biodegradation of poly(1,3-trimethylene carbonate)
K. Zhu (1991)
Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins
S. Cho (2007)
Phylogenetic perspectives in innate immunity.
J. Hoffmann (1999)
Improved antimicrobial peptides based on acyl-lysine oligomers
I. Radzishevsky (2007)
Synthesis and characterization of novel glycol-derived polycarbonates with pendant hydroxyl groups. Macromol
H. Mei (2006)
Tagging alcohols with cyclic carbonate: a versatile equivalent of (meth)acrylate for ring-opening polymerization.
R. Pratt (2008)
Antibacterial peptides: Key components needed in immunity
H. G. Boman (1991)
Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent.
L. Liu (2009)
Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action.
D. I. Chan (2006)
Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance.
K. Hiramatsu (2001)
key components needed in immunity
Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene.
S. Chang (2003)
Soft patchy nanoparticles from solution-phase self-assembly of binary diblock copolymers.
G. Srinivas (2008)
The chemistry and applications of antimicrobial polymers: a state-of-the-art review.
E. Kenawy (2007)
Antibacterial agents based on the cyclic d,l-α-peptide architecture
S. Fernandez-Lopez (2001)
enzymatic degradation and selective adsorption
J. Watanabe (2007)
X. D. Guo (2007)
Investigating the effect of increasing charge density on the hemolytic activity of synthetic antimicrobial polymers.
Zoha M. Al-Badri (2008)
Effect of composition on the formation of poly(dl-lactide) microspheres for drug delivery systems: Mesoscale simulations
Xindong Guo (2007)
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
K. Brogden (2005)
Molecular dynamic computer simulations of phase behavior of non-ionic surfactants.
Ekaterina Ryjkina (2002)
Antibacterial agents based on the cyclic D,L-alpha-peptide architecture.
S. Fernandez-Lopez (2001)
Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.
S. Kelly (1994)
Tuning the hemolytic and antibacterial activities of amphiphilic polynorbornene derivatives.
M. F. Ilker (2004)
Structures and mode of membrane interaction of a short alpha helical lytic peptide and its diastereomer determined by NMR, FTIR, and fluorescence spectroscopy.
Z. Oren (2002)
Synthesis and Characterization of Novel Glycerol-Derived Polycarbonates with Pendant Hydroxyl Groups
Hujie Mei (2006)
Mode of action of membrane active antimicrobial peptides.
Y. Shai (2002)
Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity.
A. C. Hunter (2006)
Mimicry of antimicrobial host-defense peptides by random copolymers.
Brendan P. Mowery (2007)
The determination of critical micelle concentrations of nonionic surfactants by charge-transfer solubilization of 7, 7, 8, 8 tetracyanoquinodimethane
K. Deguchi (1972)
Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach.
Karen Lienkamp (2008)
This paper is referenced by
Dual-Targeted Cascade-Responsive Prodrug Micelle System for Tumor Therapy in Vivo
Liangliang Dai (2017)
Assembling Pentatopic Terpyridine Ligand with Three Types of Coordination Moieties into Giant Supramolecular Hexagonal Prism: Synthesis, Self-Assembly, Characterization, and Antimicrobial Study.
H. Wang (2019)
A novel pH-responsive quaternary ammonium chitosan-liposome nanoparticles for periodontal treatment.
Fang Hu (2019)
Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control.
Y. Liu (2019)
Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms.
Jiaul Hoque (2015)
Antimicrobial resistance challenged with metal-based antimicrobial macromolecules.
A. Abd-El-Aziz (2017)
Synthesis of Pyrrolidinium-Type Poly(ionic liquid) Membranes for Antibacterial Applications.
J. Qin (2017)
Synergy of non-antibiotic drugs and pyrimidinethiol on gold nanoparticles against superbugs.
Yuyun Zhao (2013)
Magnetically Driven Multifunctional Nanorobots for Biomedical Applications
M. Hoop (2017)
Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells
Erika I. Geihe (2012)
Copolymers of acrylonitrile with quaternizable thiazole and triazole side-chain methacrylates as potent antimicrobial and hemocompatible systems.
Rubén Tejero (2015)
Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics
Raphaël Labruère (2019)
Bacterial-nanostructure interactions: The role of cell elasticity and adhesion forces.
A. Elbourne (2019)
Phthalocyanine functionalized poly(glycidyl methacrylate) nano-assemblies for photodynamic inactivation of bacteria.
Wei Tong (2019)
Synergistic influence of polyoxometalate surface corona towards enhancing the antibacterial performance of tyrosine-capped Ag nanoparticles.
H. Daima (2014)
Lipase-sensitive polymeric triple-layered nanogel for "on-demand" drug delivery.
Meng-Hua Xiong (2012)
Robust antimicrobial compounds and polymers derived from natural resin acids.
Jifu Wang (2012)
In Vivo Magnetic Enrichment, Photoacoustic Diagnosis, and Photothermal Purging of Infected Blood Using Multifunctional Gold and Magnetic Nanoparticles
E. Galanzha (2012)
Alpha-beta chimeric polypeptide molecular brushes display potent activity against superbugs-methicillin resistant Staphylococcus aureus
D. Zhang (2018)
Synthetic Polymers Active against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth
Runhui Liu (2014)
Organocatalytic ring-opening polymerization of morpholinones: new strategies to functionalized polyesters.
Timothy R. Blake (2014)
Polyion complex micellar nanoparticles for integrated fluorometric detection and bacteria inhibition in aqueous media.
Ya-min Li (2014)
Synergistic co-delivery of membrane-disrupting polymers with commercial antibiotics against highly opportunistic bacteria.
V. Ng (2013)
Light-triggered charge reversal of organic-silica hybrid nanoparticles.
Li-Chih Hu (2012)
Biomedical polymers from tyrosol: the influence of carbonate isomer sequence and phase behavior on erosion and mechanical performance
S. Sommerfeld (2014)
Waterborne physically crosslinked antimicrobial nanogels
S. Chattopadhyay (2016)
Sensing and antibacterial activity of imidazolium-based conjugated polydiacetylenes.
Songyi Lee (2016)
Gold nanorods core/AgPt alloy nanodots shell: A novel potent antibacterial nanostructure
Xiaona Hu (2013)
Toward Hemocompatible Self-assembling Antimicrobial Nanofibers: Understanding the Synergistic Effect of Supramolecular Structure and PEGylation on Hemocompatibility.
D. Xu (2016)
Polycarbonates derived from glucose via an organocatalytic approach.
Koichiro Mikami (2013)
Peptide polymer displaying potent activity against clinically isolated multidrug resistant Pseudomonas aeruginosa in vitro and in vivo.
Weinan Jiang (2019)
Impact of ionic liquids in aqueous solution on bacterial plasma membranes studied with molecular dynamics simulations.
G. S. Lim (2014)See more