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Cancer And Ageing: A Nexus At Several Levels
L. Balducci, W. Ershler
Published 2005 · Medicine
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Cancer is largely a disease of older people. With the relatively recent expansive growth within the geriatric population, a number of pressing biological and clinical questions that currently remain unanswered need to be addressed. These include what effect age itself has on the development or growth of cancer, and what are the benefits and risks of cancer prevention and treatment for the older person? New insights into the underlying biological processes of ageing provide a frame of reference for addressing these and other related questions.
This paper references
Overview of bevacizumab: a new cancer therapeutic strategy targeting vascular endothelial growth factor.
R. Ignoffo (2004)
Underrepresentation of patients 65 years of age or older in cancer-treatment trials.
L. Hutchins (1999)
Comorbidity and functional status are independent in older cancer patients.
M. Extermann (1998)
MALT lymphoma: from morphology to molecules
P. Isaacson (2004)
Functional Correlates of Mutations in β-Catenin Exon 3 Phosphorylation Sites*
E. Provost (2003)
Covinsky Individualized Decision Making Cancer Screening in Elderly Patients : A Framework for Correction
L. Walter (2001)
The Effects of Mammographic Detection and Comorbidity on the Survival of Older Women with Breast Cancer
C. McPherson (2002)
Congestive heart failure in patients treated with doxorubicin
S. Swain (2003)
Anemia, cancer, and aging.
L. Balducci (2003)
Comprehensive Geriatric Oncology
L. Balducci (1997)
Pegylated liposomal doxorubicin: pharmacologic and clinical evidence of potent antitumor activity with reduced anthracycline-induced cardiotoxicity (review).
M. Orditura (2004)
Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial.
C. Langer (2002)
Cancer prevention: strong science and real medicine.
S. Lippman (2005)
Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC
M. Jain (2002)
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.
M. Miwa (1998)
Mammography Use, Breast Cancer Stage at Diagnosis, and Survival Among Older Women
E. McCarthy (2000)
American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: status report 2004.
E. Winer (2005)
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
G. H. Fisher (2001)
Refining the relation between ‘first hits’ and ‘second hits’ at the APC locus: the ‘loose fit’ model and evidence for differences in somatic mutation spectra among patients
M. Crabtree (2003)
CHOP compared with CHOP plus granulocyte colony-stimulating factor in elderly patients with aggressive non-Hodgkin's lymphoma.
J. Doorduijn (2003)
Annual report to the nation on the status of cancer, 1975-2000, featuring the uses of surveillance data for cancer prevention and control.
H. Weir (2003)
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.
E. Scott (1994)
Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL.
M. Pfreundschuh (2004)
Lymphocyte-induced angiogenesis factor is produced by L3T4+ murine T lymphocytes, and its production declines with age
Eldad J. Hadar (2004)
B16 murine melanoma and aging: slower growth and longer survival in old mice.
W. Ershler (1984)
Efficacy of screening mammography. A meta-analysis.
K. Kerlikowske (1995)
Can older cancer patients tolerate chemotherapy?
H. Chen (2003)
Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps
L. Spirio (1998)
Effect of smoking cessation on major histologic types of lung cancer.
S. Khuder (2001)
The change in tumor aggressiveness with age: lessons from experimental animals.
P. Kaesberg (1989)
Essential role for oncogenic Ras in tumour maintenance
L. Chin (1999)
Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions.
M. von Knebel Doeberitz (1994)
Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study.
L. Repetto (2002)
Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer.
M. Gail (1999)
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
S. Shibutani (1991)
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis
H. Lamlum (1999)
Therapeutic monoclonal antibodies in oncology.
Adam P Levene (2005)
Antibody therapy for chronic lymphocytic leukemia: a promising new modality.
T. Lin (2004)
Impact of age and colony-stimulating factor use on hospital length of stay for febrile neutropenia in CHOP-treated non-Hodgkin's lymphoma.
E. Chrischilles (2002)
Cancer statistics, 2000
R. Greenlee (2000)
Continuing screening mammography in women aged 70 to 79 years: impact on life expectancy and cost-effectiveness.
K. Kerlikowske (1999)
Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing.
J. Gabrilove (2001)
Multidisciplinary management of lung cancer.
A. Spira (2004)
Management issues for elderly patients with breast cancer
M. Extermann (2004)
Decision analysis for cancer prevention and cancer treatment in the elderly.
M. Extermann (2005)
Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance.
R. Gelman (1984)
Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial.
U. Veronesi (2001)
Genotype-phenotype correlation in von Hippel-Lindau syndrome.
C. Friedrich (2001)
Comprehensive assessment of the elderly cancer patient: the feasibility of self-report methodology.
S. Ingram (2002)
Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis.
C. Groves (2002)
Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention.
A. Dannenberg (2005)
The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.
C. Albuquerque (2002)
The association between physical function and lifestyle activity and exercise in the Health and Aging and Body Composition study
J. S. Brach (2004)
Impact of age and colony stimulating factor use in hospital length of stay for febrile neutropenia in CHOP treated non - Hodgkin ’ s lymphoma patients
E. Chrischilles (2002)
Transfer of age-associated restrained tumor growth in mice by old-to-young bone marrow transplantation.
W. Ershler (1984)
CHOP is superior to CNOP in elderly patients with aggressive lymphoma while outcome is unaffected by filgrastim treatment: results of a Nordic Lymphoma Group randomized trial.
E. Osby (2003)
The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.
O. Sieber (2000)
Elderly aggressive-histology non-Hodgkin's lymphoma: first-line VNCOP-B regimen experience on 350 patients.
P. Zinzani (1999)
PU.1 regulates both cytokine‐dependent proliferation and differentiation of granulocyte/macrophage progenitors
R. DeKoter (1998)
Predominance of normal karyotype in colorectal tumors from hereditary non‐polyposis colorectal cancer patients
M. Muleris (1995)
Induction chemotherapy in locally advanced squamous cell cancer of the head and neck: evolution of the sequential treatment approach.
M. Posner (2004)
Relation between age and clearance rate of nine investigational anticancer drugs from phase I pharmacokinetic data
J. M. Borkowski (2004)
Reversible tumorigenesis by MYC in hematopoietic lineages.
D. Felsher (1999)
K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.
S. Guerrero (2000)
Elderly patients with aggressive non-Hodgkin's lymphoma: disease presentation, response to treatment, and survival--a Groupe d'Etude des Lymphomes de l'Adulte study on 453 patients older than 69 years.
Y. Bastion (1997)
Radioimmunotherapy of non-Hodgkin lymphomas.
B. Cheson (2003)
Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV e6‐e7 anti‐sense RNA
M. von Knebel Doeberitz (1992)
Mxi1-SRα: a novel Mxi1 isoform with enhanced transcriptional repression potential
Claire Dugast-Darzacq (2004)
PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors.
E. Scott (1997)
Signal Transduction by the TGF-β Superfamily
L. Attisano (2002)
The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas
X. Hao (2002)
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
F. Rosenbauer (2004)
The relationship between aging and carcinogenesis: a critical appraisal.
V. Anisimov (2003)
How to predict the risk of local relapse in the preserved breast.
J. Kurtz (1996)
Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer.
P. Ravdin (2001)
Guidelines for the management of the older cancer patient.
L. Balducci (2005)
P. C. Enzinger (2003)
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
M. Klemsz (1990)
Codon 12 and codon 13 mutations at the K‐ras gene induce different soft tissue sarcoma types in nude mice
S. Guerrero (2002)
Modifiers of risk of hereditary breast and ovarian cancer
S. Narod (2002)
Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature.
C. Beghé (2004)
A comprehensive geriatric intervention detects multiple problems in older breast cancer patients.
M. Extermann (2004)
Cancer screening in theory and in practice.
O. Brawley (2005)
A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients.
D. Sargent (2001)
The impact of age on delivered dose intensity and hospitalizations for febrile neutropenia in patients with intermediate-grade non-Hodgkin's lymphoma receiving initial CHOP chemotherapy: a risk factor analysis.
V. Morrison (2001)
Immunologic enhancement of b16 melanoma growth
W. Ershler (1988)
Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function
A. Newman (2003)
Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma
A. Jones (2005)
Cancer surgery in the elderly.
M. Kemeny (2000)
Frailty in older adults: evidence for a phenotype.
L. Fried (2001)
Prevention of hormone-related cancers: prostate cancer.
H. Parnes (2005)
Molecular basis of the VHL hereditary cancer syndrome
W. Kaelin (2002)
Oncologists' reluctance to accrue patients onto clinical trials: an Illinois Cancer Center study.
A. Benson (1991)
Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway.
L. Lipton (2003)
Luteinizing hormone-releasing hormone agonists in the treatment of men with prostate cancer: timing, alternatives, and the 1-year implant.
L. Marks (2003)
Cancer in the frail patient. A coming epidemic.
L. Balducci (2000)
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement
W. M. Abdel-Rahman (2001)
What Constitutes Normal Hemoglobin Concentration in Community‐Dwelling Disabled Older Women?
P. Chaves (2004)
The Association Between Physical Function and Lifestyle Activity and Exercise in the Health, Aging and Body Composition Study
J. Brach (2004)
Transcriptional Compensation for Loss of an Allele of the Ini1 Tumor Suppressor*
C. J. Guidi (2004)
Results of Adjuvant Treatments in Breast Cancer Patients over 70 Years Old: The Ibcsg Experience
D. Crivellari (2002)
Course of fatigue in women receiving chemotherapy and/or radiotherapy for early stage breast cancer.
K. Donovan (2004)
Analysis of spatial and temporal expression patterns of bone morphogenetic protein family members in the rat uterus over the estrous cycle.
G. Erickson (2004)
Acute myelogenous leukemia and aging. Clinical interactions.
J. Lancet (2000)
Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.
L. Su (2000)
Congestive heart failure in patients treated with doxorubicin : a retrospective analysis of three trials
S. M. Swain (2003)
A biological approach to mucositis.
S. Sonis (2004)
Mathematical modeling of tumorigenesis: mission possible
N. Komarova (2005)
DNA damage and aging.
Z. Karanjawala (2004)
Hyperinsulinemia in Pre- and Post-Pubertal Children Born Small for Gestational Age
N. Potau (2001)
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
A. Rowan (2000)
Annual Report to the Nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden
B. Edwards (2002)
Structural alterations of the epidermal growth factor receptor gene in human gliomas.
A. Wong (1992)
Treatment and clinical management of primary mediastinal large B-cell lymphoma with sclerosis: MACOP-B regimen and mediastinal radiotherapy monitored by (67)Gallium scan in 50 patients.
P. Zinzani (1999)
Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program.
L. A. Gloeckler Ries (2003)
Reversibility of acute B-cell leukaemia induced by BCR–ABL1
C. Huettner (2000)
Gastric MALT lymphoma: from aetiology to treatment.
M. Du (2002)
Epidemiology of primary brain tumors: current concepts and review of the literature.
M. Wrensch (2002)
Breast cancer in the elderly: the role of adjuvant radiation therapy.
P. Olmi (2003)
Radioimmunotherapy of non-Hodgkin's lymphomas.
B. Cheson (2006)
This paper is referenced by
Effective Communication with Older Cancer Patients
Lodovico Balducci (2013)
Two faces of p53: aging and tumor suppression
F. Rodier (2007)
The burden of cancer on the acute medical unit.
J. Berger (2013)
Age-specific cancer mortality trends in 16 countries
Lee R. Liu (2016)
Molecular evolution of the p53 network in reptiles
Shikha Parsai (2013)
Surgical Oncology Manual
F. C. Wright (2020)
Challenges of an ageing and dispersed population for delivering cancer services in Australia: more than just doctors needed
J. Martin (2012)
CCL5 secreted by senescent aged fibroblasts induces proliferation of prostate epithelial cells and expression of genes that modulate angiogenesis
D. Eyman (2009)
Age‐related properties of the tumour vasculature in renal cell carcinoma
B. Meehan (2011)
Aplicação do instrumento termômetro de estresse em pacientes idosos com câncer: estudo piloto* Application of the distress thermometer in elderly patients with cancer: pilot study
A. T. Lera (2011)
Vascular determinants of cancer stem cell dormancy—do age and coagulation system play a role?
J. Rak (2008)
Ageing and Cancer: A complex relationship
E. Moloney (2014)
Clinical trials of cancer treatment in the elderly
Lodovico Balducci (2015)
Multiple primary malignancies in elderly patients with high-grade soft tissue sarcoma
E. Kozawa (2013)
Immunosenescence: limitations of natural killer cell-based cancer immunotherapy
R. Tarazona (2016)
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion
J. de la Rosa (2013)
Exploring the role of circadian clock gene and association with cancer pathophysiology
M. Keshvari (2019)
A Higher CD 105-Assessed Microvessel Density and Worse Prognosis in Elderly Patients With Laryngeal Carcinoma
G. Marioni (2011)
Preventive Evolutionary Medicine of Cancers
M. Hochberg (2013)
RiskDiff: a web tool for the analysis of the difference due to risk and demographic factors for incidence or mortality data
J. Valls (2009)
GERICO: dix ans de recherche clinique en oncogériatrie
V. Girre (2011)
Applying ecological and evolutionary theory to cancer: a long and winding road
F. Thomas (2013)
The Biology of Aging and Cancer: A Complex Association
Mohit Rajput (2020)
Atherosclerosis and vascular aging as modifiers of tumor progression, angiogenesis, and responsiveness to therapy.
H. Klement (2007)
Epidemiology of Cancer in the Older‐Aged Person
L. Balducci (2013)
Cancer burden in Latin America and the Caribbean.
M. Curado (2014)
Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease.
A. Vallejo (2007)
Benefits of minimally-invasive surgery for sigmoid and rectal cancer in older adults compared with younger adults: Do older adults have the most to gain?
T. Chesney (2019)
Can Incapacitation of the Mesenchymal Endometriotic Stem Cell via the Fortification of the Immune System Lead to the Eradication of Endometriosis?
S. Vassiliadis (2011)
Risk of breast cancer in the UK biobank female cohort and its relationship to anthropometric and reproductive factors
Kawthar Alajmi (2018)
Poly Comb Group Proteins A Dual Player in Ageing and Cancer
M. Krishnaveni (2017)
RAS Oncogenes and Tumor-Vascular Interface
J. Rak (2010)See more