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Overcoming The Challenges In Administering Biopharmaceuticals: Formulation And Delivery Strategies
S. Mitragotri, P. A. Burke, R. Langer
Published 2014 · Medicine
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The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, poses substantial challenges owing to their large size and susceptibility to degradation. In this Review we highlight recent advances in formulation and delivery strategies — such as the use of microsphere-based controlled-release technologies, protein modification methods that make use of polyethylene glycol and other polymers, and genetic manipulation of biopharmaceutical drugs — and discuss their advantages and limitations. We also highlight current and emerging delivery routes that provide an alternative to injection, including transdermal, oral and pulmonary delivery routes. In addition, the potential of targeted and intracellular protein delivery is discussed.
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Yuko Iwase (2016)
Lipid-based nanovesicles for nanomedicine.
N. Grimaldi (2016)
Sensitive and Quantitative Detection of Anti-Poly(ethylene glycol) (PEG) Antibodies by Methoxy-PEG-Coated Surface Plasmon Resonance Sensors.
P. Zhang (2017)
Second osmotic virial coefficients of therapeutic proteins in the presence of excipient-mixtures can be predicted to aid an efficient formulation design
Miko Schleinitz (2019)
Structure-Based Design of Dendritic Peptide Bolaamphiphiles for siRNA Delivery
Hanxiang Zeng (2015)
Poly(lactic acid)-based particulate systems are promising tools for immune modulation.
Carina Peres (2017)
Engineered cytokine derivatives for targeted cancer immunotherapy
Dario Venetz (2016)
A novel 4-arm DNA/RNA Nanoconstruct triggering Rapid Apoptosis of Triple Negative Breast Cancer Cells within 24 hours
Joline Tung (2017)
Polylactide-tethered prodrugs in polymeric nanoparticles as reliable nanomedicines for the efficient eradication of patient-derived hepatocellular carcinoma
H. Wang (2018)See more