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Looking Back To The Embryo: Defining Transcriptional Networks In Adult Myogenesis

M. Parker, P. Seale, M. Rudnicki
Published 2003 · Biology, Medicine

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Skeletal muscle has an intrinsic capacity for regeneration following injury or exercise. The presence of adult stem cells in various tissues with myogenic potential provides new opportunities for cell-based therapies to treat muscle disease. Recent studies have shown a conserved transcriptional hierarchy that regulates the myogenic differentiation of both embryonic and adult stem cells. Importantly, the molecules and signalling pathways that induce myogenic determination in the embryo might be manipulated or mimicked to direct the differentiation of adult stem cells either in vivo or ex vivo.
This paper references
Generation of different fates from multipotent muscle stem cells.
M. Wada (2002)
Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells.
D. Cornelison (1997)
from somite to limb
Buckingham (2003)
Pax3-FKHR Knock-In Mice Show Developmental Aberrations but Do Not Develop Tumors
I. Lagutina (2002)
Clonal Isolation of Muscle-Derived Cells Capable of Enhancing Muscle Regeneration and Bone Healing
J. Lee (2000)
Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
B. Novitch (1996)
Myogenic specification of side population cells in skeletal muscle
A. Asakura (2002)
Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice
S. Tajbakhsh (1996)
MyoD is required for myogenic stem cell function in adult skeletal muscle
A. Lynn (1996)
Intraarterial Injection of Muscle-Derived Cd34+Sca-1+ Stem Cells Restores Dystrophin in mdx Mice
Y. Torrente (2001)
Transcriptional regulation during somitogenesis.
D. Summerbell (2000)
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
P. Hasty (1993)
Modular long-range regulation of Myf5 reveals unexpected heterogeneity between skeletal muscles in the mouse embryo.
J. Hadchouel (2000)
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
J. McMahon (1998)
The transition from proliferation to differentiation is delayed in satellite cells from mice lacking MyoD.
Z. Yablonka-Reuveni (1999)
Dystrophin expression in the mdx mouse restored by stem cell transplantation
E. Gussoni (1999)
Reduced Differentiation Potential of Primary MyoD−/− Myogenic Cells Derived from Adult Skeletal Muscle
L. Sabourin (1999)
Specification of the hypaxial musculature.
S. Dietrich (1998)
HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3
P. Magnaghi (1998)
The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.
I. Conboy (2002)
β-Catenin Is Essential and Sufficient for Skeletal Myogenesis in P19 Cells*
H. Petropoulos (2002)
Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification.
B. Williams (1994)
Pax3 modulates expression of the c-Met receptor during limb muscle development.
J. Epstein (1996)
Regulation of Pax-3 expression in the dermomyotome and its role in muscle development.
M. Goulding (1994)
Muscle regeneration by bone marrow-derived myogenic progenitors.
G. Ferrari (1998)
Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb.
D. Duprez (1998)
Regulation of muscle regulatory factors by DNA‐binding, interacting proteins, and post‐transcriptional modifications
P. L. Puri (2000)
Gene targeting the myf‐5 locus with nlacZ reveals expression of this myogenic factor in mature skeletal muscle fibres as well as early embryonic muscle
S. Tajbakhsh (1996)
A calcineurin- and NFAT-dependent pathway regulates Myf5 gene expression in skeletal muscle reserve cells.
B. B. Friday (2001)
MSX1 inhibits MyoD expression in fibroblast × 10T½ cell hybrids
P. Woloshin (1995)
The importance of timing differentiation during limb muscle development
H. Amthor (1998)
Control of somite patterning by signals from the lateral plate.
O. Pourquié (1995)
MSX1 inhibits myoD expression in fibroblast x 10T1/2 cell hybrids.
P. Woloshin (1995)
HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cells.
R. Tatsumi (1998)
Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2
K. Sakuma (2002)
Wnt Signaling Regulates the Function of MyoD and Myogenin*
A. G. Ridgeway (2000)
Expression of Cd34 and Myf5 Defines the Majority of Quiescent Adult Skeletal Muscle Satellite Cells
J. Beauchamp (2000)
Myogenic satellite cells: physiology to molecular biology.
Thomas J. Hawke (2001)
Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation.
E. Hirsinger (2001)
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
M. Goodell (1996)
Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
A. Musarò (2001)
Severe defects in the formation of epaxial musculature in open brain (opb) mutant mouse embryos.
R. Spörle (1996)
Early specification of limb muscle precursor cells by the homeobox gene Lbx1h
K. Schäfer (1999)
Myf-5 is transiently expressed in nonmuscle mesoderm and exhibits dynamic regional changes within the presegmented mesoderm and somites I-IV.
J. Kiefer (2001)
Activation of myogenesis by the homeobox gene Lbx1 requires cell proliferation
D. Mennerich (2001)
Myf-5 Revisited Loss of Early Myotome Formation Does Not Lead to a Rib Phenotype in Homozygous Myf-5 Mutant Mice
Axel Kaul (2000)
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification.
M. Gustafsson (2002)
Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.
T. Heanue (1999)
Inactivation of Myf‐6 and Myf‐5 genes in mice leads to alterations in skeletal muscle development.
T. Braun (1995)
Adult skeletal muscle growth and regeneration: The development and differentiation of myogenic stem cells
P. Seale (2002)
Pax7 Is Required for the Specification of Myogenic Satellite Cells
P. Seale (2000)
Early stages of chick somite development
B. Christ (2004)
Ontogeny of the endothelial system in the avian model.
L. Pardanaud (2000)
A Somitic Compartment of Tendon Progenitors
A. E. Brent (2003)
Cultured myf5 null and myoD null muscle precursor cells display distinct growth defects
D. Montarras (2000)
Satellite cell proliferative compartments in growing skeletal muscles.
E. Schultz (1996)
Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice
R. Bittner (1999)
MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle.
B. Kablar (1997)
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
F. Bladt (1995)
Hepatocyte growth factor activates quiescent skeletal muscle satellite cells in vitro
R. Allen (1995)
Apoptosis of epaxial myotome in Danforth's short-tail (Sd) mice in somites that form following notochord degeneration.
A. Asakura (1998)
Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning.
E. Hirsinger (1997)
Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
Margaret A. Goodell (1997)
Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies.
W. Zhang (1995)
A Natural Hepatocyte Growth Factor/Scatter Factor Autocrine Loop in Myoblast Cells and the Effect of the Constitutive Met Kinase Activation on Myogenic Differentiation
S. Anastasi (1997)
Myogenic determination occurs independently in somites and limb buds.
B. Kablar (1999)
Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4
O. Pourquié (1996)
Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
S. Tajbakhsh (1997)
Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene.
F. Naya (1999)
Temporal expression of myogenic regulatory genes during activation, proliferation, and differentiation of rat skeletal muscle satellite cells
C. K. Smith (1994)
Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation.
A. Asakura (2001)
A molecular mechanism enabling continuous embryonic muscle growth - a balance between proliferation and differentiation.
H. Amthor (1999)
Two myogenic lineages within the developing somite.
C. Ordahl (1992)
Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.
F. Spitz (1998)
physiology to molecular biology
T. J. Hawke (2001)
a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation
F. S. Naya (1999)
Origin of satellite cells in avian skeletal muscles.
O. Armand (1983)
TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3.
D. Liu (2001)
Ectopic Pax-3 Activates MyoD and Myf-5 Expression in Embryonic Mesoderm and Neural Tissue
M. Maroto (1997)
X‐Irradiation improves mdx mouse muscle as a model of myofiber loss in DMD
S. Wakeford (1991)
Gene Expression During the Life Cycle of Drosophila melanogaster
E. Salmon (2002)
Stem Cells: A Cellular Fountain of Youth
M. Mattson (2002)
A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors.
P. Tremblay (1998)
Delta 1-activated notch inhibits muscle differentiation without affecting Myf5 and Pax3 expression in chick limb myogenesis.
M. Delfini (2000)
Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis.
P. Naidu (1995)
Myogenin gene disruption results in perinatal lethality because of severe muscle defect
Y. Nabeshima (1993)
Involvement of numb in vertebrate retinal development: evidence for multiple roles of numb in neural differentiation and maturation.
C. Dooley (2003)
Dedifferentiation of Mammalian Myotubes Induced by msx1
S. Odelberg (2000)
Pax3 Is Essential for Skeletal Myogenesis and the Expression of Six1 and Eya2*
A. G. Ridgeway (2001)
Inscuteable‐independent apicobasally oriented asymmetric divisions in the Drosophila embryonic CNS
P. Rath (2002)
The role of the notochord for epaxial myotome formation in the mouse.
S. Dietrich (1999)
MEF 2 : a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation
F. Naya (1999)
MyoD(-/-) satellite cells in single-fiber culture are differentiation defective and MRF4 deficient.
D. Cornelison (2000)
Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration.
D. Cornelison (2001)
Pax3 and Dach2 positive regulation in the developing somite
G. Kardon (2002)
MyoD or Myf-5 is required for the formation of skeletal muscle
M. Rudnicki (1993)
Invertebrate myogenesis: looking back to the future of muscle development.
M. Baylies (2001)
Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors.
A. Bendall (1999)
Sonic hedgehog is a survival factor for hypaxial muscles during mouse development.
M. Krueger (2001)
Vertebrate somitogenesis.
O. Pourquié (2001)
The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system
B. Jostes (1990)
The expression of Myf5 in the developing mouse embryo is controlled by discrete and dispersed enhancers specific for particular populations of skeletal muscle precursors.
D. Summerbell (2000)
The formation of skeletal muscle: from somite to limb
M. Buckingham (2003)
Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5.
S. Tajbakhsh (1998)
Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.
Q. Shen (2002)
MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation.
F. Naya (1999)
Slug Is a Novel Downstream Target of MyoD
P. Zhao (2002)
Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.
A. Patapoutian (1995)
A Cellular Fountain of Youth (eds Mattson, M
P. Seale (2002)
a role for BMP4
Pourquie (1996)
Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse.
G. Daston (1996)
Covert persistence of mdx mouse myopathy is revealed by acute and chronic effects of irradiation
C. Pagel (1999)
Sonic hedgehog controls epaxial muscle determination through Myf5 activation.
A. Borycki (1999)
Molecular Distinction between Specification and Differentiation in the Myogenic Basic Helix-Loop-Helix Transcription Factor Family
D. Bergstrom (2001)
cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene.
J. Khan (1999)
The current status of myoblast transfer
T. Patridge (2000)
Molecular mechanisms regulating myogenic determination and differentiation.
Perry Rl (2000)
Myogenic regulatory factors and the specification of muscle progenitors in vertebrate embryos.
M. Pownall (2002)
Lbx1 is required for muscle precursor migration along a lateral pathway into the limb.
M. K. Gross (2000)
The homeobox gene Msx1 is expressed in a subset of somites, and in muscle progenitor cells migrating into the forelimb.
D. Houzelstein (1999)
Knowing chops from chuck: roasting myoD redundancy.
C. Ordahl (1998)
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells.
E. Bober (1994)
Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression.
R. Reshef (1998)
A new look at the origin, function, and "stem-cell" status of muscle satellite cells.
P. Seale (2000)
Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos.
U. Borello (1999)
Altered myogenesis in Six1-deficient mice
C. Laclef (2003)
roasting myoD redundancy
C. P. Ordahl (1998)
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
C. Chiang (1996)
Biological Progression from Adult Bone Marrow to Mononucleate Muscle Stem Cell to Multinucleate Muscle Fiber in Response to Injury
M. Labarge (2002)
Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb
D. Mennerich (1998)
pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation
B. Novitch (1999)
Molecular mechanisms regulating myogenic determination and differentiation.
R. L. Perry (2000)
The role of Lbx1 in migration of muscle precursor cells.
H. Brohmann (2000)
IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1
A. Musarò (1999)
Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway
C. Semsarian (1999)
A BAC transgenic analysis of the Mrf4/Myf5 locus reveals interdigitated elements that control activation and maintenance of gene expression during muscle development.
J. Carvajal (2001)
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
J. Lin (2002)
Myocyte Enhancer Factor 2C and Myogenin Up-regulate Each Other's Expression and Induce the Development of Skeletal Muscle in P19 Cells*
A. G. Ridgeway (2000)
Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression.
D. Bergstrom (2002)
Pax3 functions in cell survival and in pax7 regulation.
A. Borycki (1999)
Activation of different myogenic pathways: myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm.
G. Cossu (1996)
Skeletal Myogenic Progenitors Originating from Embryonic Dorsal Aorta Coexpress Endothelial and Myogenic Markers and Contribute to Postnatal Muscle Growth and Regeneration
L. De Angelis (1999)

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I. L. de la Serna (2005)
CGRP, a vasodilator neuropeptide that stimulates neuromuscular transmission and EC coupling.
Ana V. Vega (2010)
Muscular laminopathies: role of prelamin A in early steps of muscle differentiation.
N. Maraldi (2011)
Cross talk between matrix elasticity and mechanical force regulates myoblast traction dynamics.
Z. Al-Rekabi (2013)
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Zoran Groznica (2005)
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C. Imbriano (2018)
A common somitic origin for embryonic muscle progenitors and satellite cells
J. Gros (2005)
Identification of differentially expressed genes in longissimus muscle of pigs with high and low intramuscular fat content using RNA sequencing
K. Lim (2017)
MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration
Christine M Snyder (2013)
Expression of the paired box domain Pax7 protein in myogenic cells isolated from the porcine semitendinosus muscle after birth.
M. Patruno (2008)
Signals from damaged but not undamaged skeletal muscle induce myogenic differentiation of rat bone-marrow-derived mesenchymal stem cells.
L. Santa María (2004)
Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein.
T. Nakane (2004)
Transcriptome analysis of cattle muscle identifies potential markers for skeletal muscle growth rate and major cell types
B. Guo (2015)
Extremely Low-Frequency Electromagnetic Fields Affect Myogenic Processes in C2C12 Myoblasts: Role of Gap-Junction-Mediated Intercellular Communication
C. Morabito (2017)
p38 mitogen-activated protein kinase up-regulates NF-kappaB transcriptional activation through RelA phosphorylation during stretch-induced myogenesis.
Guoping Ji (2010)
Sequence, conservation, and quantitative expression of rainbow trout Myf5.
K. A. Johansen (2005)
Ca2+ channel regulation by transforming growth factor‐β1 and bone morphogenetic protein‐2 in developing mice myotubes
Lizbeth Mejia-Luna (2004)
Non-Coding RNAs in Muscle Dystrophies
D. Erriquez (2013)
Role of IGF-I in skeletal muscle mass maintenance
D. Clemmons (2009)
Generation of a new Tbx6-inducible reporter mouse line to trace presomitic mesoderm derivatives throughout development and in adults
Laurent Yvernogeau (2020)
Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway.
L. Vallier (2004)
Differentiated evolutionary relationships among chordates from comparative alignments of multiple sequences of MyoD and MyoG myogenic regulatory factors.
L. C. Oliani (2015)
Specificity of Notch pathway activation: Twist controls the transcriptional output in adult muscle progenitors
Fred Bernard (2010)
Role of A-type lamins in signaling, transcription, and chromatin organization
V. Andrés (2009)
Diversification of the muscle proteome through alternative splicing
Kiran Nakka (2018)
Rôle du facteur de transcription Srf au cours de l’atrophie du muscle squelettique et dans les cellules satellites
Laura Collard (2013)
Investigating the Molecular Mechanisms Involved in Skeletal Muscle Development: NF-kappa B and Skeletal Myogenesis
Jason M. Dahlman (2009)
Tumor Necrosis Factor-like Weak Inducer of Apoptosis Inhibits Skeletal Myogenesis through Sustained Activation of Nuclear Factor-κB and Degradation of MyoD Protein*
Charu Dogra (2006)
Regulation of the Mammalian SWI/SNF Family of Chromatin Remodeling Enzymes by Phosphorylation during Myogenesis
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