Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Modulation Of Functional Pendant Chains Within Poly(ethylene Glycol) Hydrogels For Refined Control Of Protein Release
Mirae Kim, Chaenyung Cha
Published 2018 · Chemistry, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Hydrogels are highly attractive delivery vehicles for therapeutic proteins. Their innate biocompatibility, hydrophilicity and aqueous permeability allow stable encapsulation and release of proteins. The release rates also can be controlled simply by altering the crosslinking density of the polymeric network. However, the crosslinking density also influences the mechanical properties of hydrogels, generally opposite to the permeability. In addition, the release of larger proteins may be hindered below critically diminished porosity determined by the crosslinking density. Herein, the physical properties of the hydrogels are tuned by presenting functional pendant chains, independent of crosslinking density. Heterobifunctional poly(ethylene glycol) monomethacrylate (PEGMA) with various end functional groups is synthesized and copolymerized with PEG dimethacrylate (PEGDA) to engineer PEG hydrogels with pendant PEG chains. The pendant chains of the PEG hydrogels consisting of sulfonate, trimethylammonium chloride, and phenyl groups are utilized to provide negative charge, positive charge and hydrophobicity, respectively, to the hydrogels. The release rates of proteins with different isoelectric points are controlled in a wide range by the type and the density of functional pendant chains via electrostatic and hydrophobic interactions.
This paper references
scaffold design variables and applications
J. L. Drury (2003)
Polymeric hydrogels for oral insulin delivery.
K. Chaturvedi (2013)
Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function.
Laney M Weber (2009)
Hydrogels for protein delivery.
T. Vermonden (2012)
Poly(ethylene glycol)-poly(lactic-co-glycolic acid) core–shell microspheres with enhanced controllability of drug encapsulation and release rate
Chaenyung Cha (2015)
Heterobifunctional Poly ( ethy 1 ene oxide ) : Synthesis of a-Methoxy-mamino and a-Hydroxy-mamino PEOs with the Same Molecular Weights
S. Cammas (2001)
RGD and other recognition sequences for integrins.
E. Ruoslahti (1996)
Reassessing fast water transport through carbon nanotubes.
J. A. Thomas (2008)
Heterobifunctional poly(ethylene oxide): synthesis of alpha-methoxy-omega-amino and alpha-hydroxy-omega-amino PEOs with the same molecular weights.
S. Cammas (1995)
Synthesis and swelling behavior of xanthan-based hydrogels.
V. Bueno (2013)
Effects of precursor composition and mode of crosslinking on mechanical properties of graphene oxide reinforced composite hydrogels.
J. Jang (2017)
In vitro degradation and protein release of transparent and opaque physical hydrogels of block copolymers at body temperature
L. Yu (2012)
Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells.
S. Vinogradov (2002)
Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering.
JunMin Zhu (2010)
Hydrogels for protein
T. Vermonden (2012)
Modeling of effect of initial fixed charge density on smart hydrogel response to ionic strength of environmental solution
F. Lai (2010)
Controlled release of insulin from pH/temperature-sensitive injectable pentablock copolymer hydrogel.
D. Huynh (2009)
Comprehensive Examination of Mechanical and Diffusional Effects on Cell Behavior Using a Decoupled 3D Hydrogel System.
Suntae Kim (2017)
Poly(ethylene glycol)-poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications.
A. Alexander (2013)
Development of novel photopolymerizable hyaluronic acid/heparin-based hydrogel scaffolds with a controlled release of growth factors for enhanced bone regeneration
M. Bae (2016)
Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems
Y. Fu (2010)
Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. II. Evaluation of a possible swelling-controlled drug release mechanism using dimensionless analysis.
C. Ferrero (2010)
Hydrogels used for cell-based drug delivery.
John J. Schmidt (2008)
Novel functional biodegradable polymer IV: pH-sensitive controlled release of fibroblast growth factor-2 from a poly(gamma-glutamic acid)-sulfonate matrix for tissue engineering.
M. Matsusaki (2005)
Mucoadhesive interactions of amphiphilic cationic copolymers based on [2-(methacryloyloxy)ethyl]trimethylammonium chloride.
N. A. Fefelova (2007)
Molecular aspects of ligand binding to serum albumin.
U. Kragh-Hansen (1981)
Poly(ethylene glycol)-containing hydrogels in drug delivery.
N. Peppas (1999)
Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels.
Laura Serra (2006)
Poly(ethylene glycol)-poly(lactic-co-glycolic acid) core–shell microspheres with enhanced controllability of drug encapsulation and release
C. Cha (2015)
Poly(ethylene glycol)-containing hydrogels in drug
N. A. Peppas (1999)
PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine
Chien-Chi Lin (2008)
Biomimetic and photo crosslinked hyaluronic acid/pluronic F127 hydrogels with enhanced mechanical and elastic properties to be applied in tissue engineering
Sang Soo Sohn (2016)
Refined control of thermoresponsive swelling/deswelling and drug release properties of poly(N-isopropylacrylamide) hydrogels using hydrophilic polymer crosslinkers
Suntae Kim (2016)
Visible-light-induced synthesis of pH-responsive composite hydrogels for controlled delivery of the anticonvulsant drug pregabalin.
O. Cevik (2015)
Therapeutic cell delivery and fate control in hydrogels and hydrogel hybrids.
C. Wang (2010)
progress and challenges
T. R. Hoare (2008)
Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels.
G. Cruise (1998)
Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L Drury (2003)
Synthesis of a-methoxy-w-amino and a-hydroxyw-amino PEOs with the same molecular weights
S. Cammas (1995)
Decoupled control of stiffness and permeability with a cell-encapsulating poly(ethylene glycol) dimethacrylate hydrogel.
Chaenyung Cha (2010)
Fast Mass Transport Through Sub-2-Nanometer Carbon Nanotubes
J. K. Holt (2006)
Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).
J. Siepmann (2001)
HYDROGELS IN DRUG DELIVERY: PROGRESS AND CHALLENGES
T. Hoare (2008)
Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds with tunable degradation and mechanical properties.
S. Zustiak (2010)
pH-sensitive controlled release of fibroblast growth factor-2 from a poly(γ-glutamic acid)-sulfonate matrix for tissue engineering
M. Matsusaki (2005)
Biodegradable Polymer Crosslinker: Independent Control of Stiffness, Toughness, and Hydrogel Degradation Rate
Chaenyung Cha (2009)
Effect of bentonite on the physical properties and drug‐release behavior of poly(AA‐co‐PEGMEA)/bentonite nanocomposite hydrogels for mucoadhesive
W. Lee (2004)
Thermoreversible hydrogels. VIII. Effect of a zwitterionic monomer on swelling behaviors of thermosensitive hydrogels copolymerized by N-isopropylacrylamide with N,N′-dimethyl (acrylamidopropyl) ammonium propane sulfonate
W. Lee (1999)
Synthesis of heterotelechelic poly(ethylene glycol) derivatives having alpha-benzaldehyde and omega-pyridyl disulfide groups by ring opening polymerization of ethylene oxide using 4-(diethoxymethyl)benzyl alkoxide as a novel initiator.
Y. Akiyama (2004)
Mechanical properties of hydrogels and their experimental determination.
K. Anseth (1996)
Heterobifunctional poly(ethylene glycol) : Synthesis of α-methoxy-ω-amino and α-hydroxy-ω-amino PEOs with the same molecular weights
S. Cammas (1995)
This paper is referenced by
The Combined Effects of Co-Culture and Substrate Mechanics on 3D Tumor Spheroid Formation within Microgels Prepared via Flow-Focusing Microfluidic Fabrication
D. Lee (2018)
Complex Tuning of Physical Properties of Hyperbranched Polyglycerol‐Based Bioink for Microfabrication of Cell‐Laden Hydrogels
Jisu Hong (2019)
Controlling Fluid Diffusion and Release through Mixed-Molecular-Weight Poly(ethylene) Glycol Diacrylate (PEGDA) Hydrogels
Kieran O’Donnell (2019)
In situ facile-forming chitosan hydrogels with tunable physicomechanical and tissue adhesive properties by polymer graft architecture.
Mirae Kim (2020)
Inflammation targeted chitosan-based hydrogel for controlled release of diclofenac sodium.
N. Gull (2020)
Controlled release from PCL-alginate microspheres via secondary encapsulation using GelMA/HAMA hydrogel scaffolds.
Lilith M Caballero Aguilar (2019)
A review of cryogels synthesis, characterization and applications on the removal of heavy metals from aqueous solutions.
A. Baimenov (2019)
Tunable Engineering of Heparinized Injectable Hydrogels for Affinity‐Based Sustained Delivery of Bioactive Factors
S. H. Kim (2019)
Neural tissue engineering with structured hydrogels in CNS models and therapies.
J. George (2019)