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Modulation Of Functional Pendant Chains Within Poly(ethylene Glycol) Hydrogels For Refined Control Of Protein Release

Mirae Kim, Chaenyung Cha
Published 2018 · Chemistry, Medicine

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Hydrogels are highly attractive delivery vehicles for therapeutic proteins. Their innate biocompatibility, hydrophilicity and aqueous permeability allow stable encapsulation and release of proteins. The release rates also can be controlled simply by altering the crosslinking density of the polymeric network. However, the crosslinking density also influences the mechanical properties of hydrogels, generally opposite to the permeability. In addition, the release of larger proteins may be hindered below critically diminished porosity determined by the crosslinking density. Herein, the physical properties of the hydrogels are tuned by presenting functional pendant chains, independent of crosslinking density. Heterobifunctional poly(ethylene glycol) monomethacrylate (PEGMA) with various end functional groups is synthesized and copolymerized with PEG dimethacrylate (PEGDA) to engineer PEG hydrogels with pendant PEG chains. The pendant chains of the PEG hydrogels consisting of sulfonate, trimethylammonium chloride, and phenyl groups are utilized to provide negative charge, positive charge and hydrophobicity, respectively, to the hydrogels. The release rates of proteins with different isoelectric points are controlled in a wide range by the type and the density of functional pendant chains via electrostatic and hydrophobic interactions.
This paper references
scaffold design variables and applications
J. L. Drury (2003)
10.1016/j.jconrel.2012.11.005
Polymeric hydrogels for oral insulin delivery.
K. Chaturvedi (2013)
10.1002/jbm.a.32134
Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function.
Laney M Weber (2009)
10.1021/cr200157d
Hydrogels for protein delivery.
T. Vermonden (2012)
10.1080/09205063.2015.1058575
Poly(ethylene glycol)-poly(lactic-co-glycolic acid) core–shell microspheres with enhanced controllability of drug encapsulation and release rate
Chaenyung Cha (2015)
Heterobifunctional Poly ( ethy 1 ene oxide ) : Synthesis of a-Methoxy-mamino and a-Hydroxy-mamino PEOs with the Same Molecular Weights
S. Cammas (2001)
10.1146/ANNUREV.CELLBIO.12.1.697
RGD and other recognition sequences for integrins.
E. Ruoslahti (1996)
10.1021/nl8013617
Reassessing fast water transport through carbon nanotubes.
J. A. Thomas (2008)
10.1021/BC00032A011
Heterobifunctional poly(ethylene oxide): synthesis of alpha-methoxy-omega-amino and alpha-hydroxy-omega-amino PEOs with the same molecular weights.
S. Cammas (1995)
10.1016/j.carbpol.2012.10.062
Synthesis and swelling behavior of xanthan-based hydrogels.
V. Bueno (2013)
10.1016/j.jmbbm.2017.01.025
Effects of precursor composition and mode of crosslinking on mechanical properties of graphene oxide reinforced composite hydrogels.
J. Jang (2017)
10.1007/s13233-012-0049-7
In vitro degradation and protein release of transparent and opaque physical hydrogels of block copolymers at body temperature
L. Yu (2012)
10.1016/S0169-409X(01)00245-9
Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells.
S. Vinogradov (2002)
10.1016/j.biomaterials.2010.02.044
Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering.
JunMin Zhu (2010)
Hydrogels for protein
T. Vermonden (2012)
10.1039/B913841B
Modeling of effect of initial fixed charge density on smart hydrogel response to ionic strength of environmental solution
F. Lai (2010)
10.1016/j.jconrel.2009.02.021
Controlled release of insulin from pH/temperature-sensitive injectable pentablock copolymer hydrogel.
D. Huynh (2009)
10.1002/mabi.201700162
Comprehensive Examination of Mechanical and Diffusional Effects on Cell Behavior Using a Decoupled 3D Hydrogel System.
Suntae Kim (2017)
10.1016/j.jconrel.2013.10.006
Poly(ethylene glycol)-poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications.
A. Alexander (2013)
10.1007/s13233-016-4112-7
Development of novel photopolymerizable hyaluronic acid/heparin-based hydrogel scaffolds with a controlled release of growth factors for enhanced bone regeneration
M. Bae (2016)
10.1517/17425241003602259
Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems
Y. Fu (2010)
10.1016/j.jconrel.2009.09.011
Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. II. Evaluation of a possible swelling-controlled drug release mechanism using dimensionless analysis.
C. Ferrero (2010)
10.1002/jbm.a.32287
Hydrogels used for cell-based drug delivery.
John J. Schmidt (2008)
10.1021/BM050369M
Novel functional biodegradable polymer IV: pH-sensitive controlled release of fibroblast growth factor-2 from a poly(gamma-glutamic acid)-sulfonate matrix for tissue engineering.
M. Matsusaki (2005)
10.1016/J.IJPHARM.2007.02.019
Mucoadhesive interactions of amphiphilic cationic copolymers based on [2-(methacryloyloxy)ethyl]trimethylammonium chloride.
N. A. Fefelova (2007)
Molecular aspects of ligand binding to serum albumin.
U. Kragh-Hansen (1981)
10.1016/S0168-3659(99)00027-9
Poly(ethylene glycol)-containing hydrogels in drug delivery.
N. Peppas (1999)
10.1016/J.BIOMATERIALS.2006.06.011
Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels.
Laura Serra (2006)
Poly(ethylene glycol)-poly(lactic-co-glycolic acid) core–shell microspheres with enhanced controllability of drug encapsulation and release
C. Cha (2015)
Poly(ethylene glycol)-containing hydrogels in drug
N. A. Peppas (1999)
10.1007/s11095-008-9801-2
PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine
Chien-Chi Lin (2008)
10.1007/s13233-016-4029-1
Biomimetic and photo crosslinked hyaluronic acid/pluronic F127 hydrogels with enhanced mechanical and elastic properties to be applied in tissue engineering
Sang Soo Sohn (2016)
10.1080/09205063.2016.1230933
Refined control of thermoresponsive swelling/deswelling and drug release properties of poly(N-isopropylacrylamide) hydrogels using hydrophilic polymer crosslinkers
Suntae Kim (2016)
10.1016/j.actbio.2014.09.018
Visible-light-induced synthesis of pH-responsive composite hydrogels for controlled delivery of the anticonvulsant drug pregabalin.
O. Cevik (2015)
10.1016/j.addr.2010.02.001
Therapeutic cell delivery and fate control in hydrogels and hydrogel hybrids.
C. Wang (2010)
progress and challenges
T. R. Hoare (2008)
10.1016/S0142-9612(98)00025-8
Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels.
G. Cruise (1998)
10.1016/S0142-9612(03)00340-5
Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L Drury (2003)
Synthesis of a-methoxy-w-amino and a-hydroxyw-amino PEOs with the same molecular weights
S. Cammas (1995)
10.1016/j.biomaterials.2010.02.059
Decoupled control of stiffness and permeability with a cell-encapsulating poly(ethylene glycol) dimethacrylate hydrogel.
Chaenyung Cha (2010)
10.1126/science.1126298
Fast Mass Transport Through Sub-2-Nanometer Carbon Nanotubes
J. K. Holt (2006)
10.1016/j.addr.2012.09.028
Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).
J. Siepmann (2001)
10.1016/J.POLYMER.2008.01.027
HYDROGELS IN DRUG DELIVERY: PROGRESS AND CHALLENGES
T. Hoare (2008)
10.1021/bm100137q
Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds with tunable degradation and mechanical properties.
S. Zustiak (2010)
pH-sensitive controlled release of fibroblast growth factor-2 from a poly(γ-glutamic acid)-sulfonate matrix for tissue engineering
M. Matsusaki (2005)
10.1002/ADFM.200900865
Biodegradable Polymer Crosslinker: Independent Control of Stiffness, Toughness, and Hydrogel Degradation Rate
Chaenyung Cha (2009)
10.1002/APP.13499
Effect of bentonite on the physical properties and drug‐release behavior of poly(AA‐co‐PEGMEA)/bentonite nanocomposite hydrogels for mucoadhesive
W. Lee (2004)
10.1002/(SICI)1097-4628(19991128)74:9<2170::AID-APP7>3.0.CO;2-Q
Thermoreversible hydrogels. VIII. Effect of a zwitterionic monomer on swelling behaviors of thermosensitive hydrogels copolymerized by N-isopropylacrylamide with N,N′-dimethyl (acrylamidopropyl) ammonium propane sulfonate
W. Lee (1999)
10.1021/BC0341775
Synthesis of heterotelechelic poly(ethylene glycol) derivatives having alpha-benzaldehyde and omega-pyridyl disulfide groups by ring opening polymerization of ethylene oxide using 4-(diethoxymethyl)benzyl alkoxide as a novel initiator.
Y. Akiyama (2004)
10.1016/0142-9612(96)87644-7
Mechanical properties of hydrogels and their experimental determination.
K. Anseth (1996)
Heterobifunctional poly(ethylene glycol) : Synthesis of α-methoxy-ω-amino and α-hydroxy-ω-amino PEOs with the same molecular weights
S. Cammas (1995)



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