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Apolipoprotein E4 Effects On Topological Brain Network Organization In Mild Cognitive Impairment

Gretel Sanabria-Diaz, L. Melie-García, Bogdan Draganski, J. Démonet, Ferath Kherif
Published 2021 · Medicine

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The Apolipoprotein E isoform E4 (ApoE4) is consistently associated with an elevated risk of developing late-onset Alzheimer’s Disease (AD); however, less is known about the potential genetic modulation of the brain networks organization during prodromal stages like Mild Cognitive Impairment (MCI). To investigate this issue during this critical stage, we used a dataset with a cross-sectional sample of 253 MCI patients divided into ApoE4 - positive (‛Carriers’) and ApoE4 - negative (‘non-Carriers’). We estimated the cortical thickness (CT) from high-resolution T1-weighted structural magnetic images to calculate the correlation among anatomical regions across subjects and build the CT covariance networks ( CT-Nets ). The topological properties of CT-Nets were described through the graph theory approach. Specifically, our results showed a significant decrease in characteristic path length, clustering-index, local efficiency, global connectivity, modularity, and increased global efficiency for Carriers compared to non-Carriers. Overall, we found that ApoE4 in MCI shaped the topological organization of CT-Nets . Our results suggest that in the MCI stage, the ApoE4 disrupting the CT correlation between regions may be due to adaptive mechanisms to sustain the information transmission across distant brain regions to maintain the cognitive and behavioral abilities before the occurrence of the most severe symptoms.
This paper references
10.2307/3033543
A set of measures of centrality based upon betweenness
L. Freeman (1977)
10.1137/1.9781611970319
The jackknife, the bootstrap, and other resampling plans
B. Efron (1987)
B Efron (1994)
10.1109/42.668698
A nonparametric method for automatic correction of intensity nonuniformity in MRI data
J. Sled (1998)
10.1038/30918
Collective dynamics of ‘small-world’ networks
D. Watts (1998)
RC Petersen (2000)
10.1073/PNAS.98.2.676
A default mode of brain function.
M. Raichle (2001)
10.1103/PhysRevLett.87.198701
Efficient behavior of small-world networks.
V. Latora (2001)
10.1016/S1364-6613(03)00197-9
Persistent activity in the prefrontal cortex during working memory
(2003)
10.1023/A:1023832305702
Alzheimer' Disease as a Disconnection Syndrome?
X. Delbeuck (2003)
10.1126/SCIENCE.1100301
The Role of the Medial Frontal Cortex in Cognitive Control
K. R. Ridderinkhof (2004)
10.1093/CERCOR/BHG087
Automatically parcellating the human cerebral cortex.
B. Fischl (2004)
10.1103/PhysRevE.69.026113
Finding and evaluating community structure in networks.
M. Newman (2003)
10.1140/EPJB/E2004-00123-0
Self-contained algorithms to detect communities in networks
C. Castellano (2004)
10.1212/01.WNL.0000144279.21502.B7
Impact of APOE in mild cognitive impairment
M. Farlow (2004)
O Sporns (2004)
10.1016/j.jalz.2005.06.003
Ways toward an early diagnosis in Alzheimer’s disease: The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
S. Mueller (2005)
10.1016/j.neuroimage.2004.12.052
Cortical thickness analysis in autism with heat kernel smoothing
M. Chung (2005)
10.1016/j.neuroimage.2006.01.042
Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI
J. Lerch (2006)
10.1523/JNEUROSCI.1138-06.2006
On Measuring the Perceived Onsets of Spontaneous Actions
H. Lau (2006)
10.1016/j.neuroimage.2005.09.046
Reliability in multi-site structural MRI studies: Effects of gradient non-linearity correction on phantom and human data
J. Jovicich (2006)
10.1016/J.PHYSREP.2005.10.009
Complex networks: Structure and dynamics
S. Boccaletti (2006)
10.1159/000109150
Neuroimaging and APOE Genotype: A Systematic Qualitative Review
N. Cherbuin (2007)
10.1093/CERCOR/BHJ127
Small-world networks and functional connectivity in Alzheimer's disease.
C. Stam (2006)
10.1093/CERCOR/BHL149
Small-world anatomical networks in the human brain revealed by cortical thickness from MRI.
Yong He (2007)
10.1111/j.1468-1331.2006.01579.x
Decreased cerebral blood flow velocity in apolipoprotein E ɛ4 allele carriers with mild cognitive impairment
Z-W Sun (2007)
10.1371/journal.pcbi.0030017
Efficiency and Cost of Economical Brain Functional Networks
S. Achard (2007)
10.1002/hbm.20381
Variability of the paracingulate sulcus and morphometry of the medial frontal cortex: Associations with cortical thickness, surface area, volume, and sulcal depth
A. Fornito (2008)
10.1196/annals.1440.011
The Brain's Default Network
Randy L. Buckner (2008)
10.1016/j.neuroimage.2007.08.042
Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths
B. Dickerson (2008)
10.1073/pnas.0800376105
The maturing architecture of the brain's default network
D. Fair (2008)
10.1371/journal.pcbi.1000100
Network Analysis of Intrinsic Functional Brain Connectivity in Alzheimer's Disease
Kaustubh Supekar (2008)
10.1523/JNEUROSCI.0141-08.2008
Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer's Disease
Yong He (2008)
10.1093/brain/awp089
Impaired small-world efficiency in structural cortical networks in multiple sclerosis associated with white matter lesion load.
Yong He (2009)
M Bastian (2009)
10.1016/j.jalz.2010.03.013
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
A. Saykin (2010)
10.1016/j.neuroimage.2010.06.010
Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature
C. Destrieux (2010)
10.1523/JNEUROSCI.4136-10.2010
Diffusion Tensor Tractography Reveals Abnormal Topological Organization in Structural Cortical Networks in Alzheimer's Disease
C. Lo (2010)
10.1016/j.neuroimage.2010.06.041
Network-based statistic: Identifying differences in brain networks
A. Zalesky (2010)
10.1212/WNL.0b013e3181cb3e25
Alzheimer's Disease Neuroimaging Initiative (ADNI)
R. Petersen (2010)
10.1016/j.neuroimage.2009.10.003
Complex network measures of brain connectivity: Uses and interpretations
M. Rubinov (2010)
10.1371/journal.pcbi.1000736
Dynamics and Control of Diseases in Networks with Community Structure
M. Salathé (2010)
10.1016/j.neuroimage.2010.01.028
Surface area and cortical thickness descriptors reveal different attributes of the structural human brain networks
Gretel Sanabria-Diaz (2010)
10.1371/journal.pone.0019584
Reorganization of Functional Networks in Mild Cognitive Impairment
J. Buldú (2011)
10.4061/2011/726197
The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations
Elizabeth R. Tuminello (2011)
10.1038/nn.2801
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Adam W. Bero (2011)
10.1016/j.jalz.2011.03.008
The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
M. Albert (2011)
10.1146/annurev-clinpsy-040510-143934
Brain graphs: graphical models of the human brain connectome.
E. Bullmore (2011)
10.1159/000330492
Regional Differences in Effects of APOE ε4 on Cognitive Impairment in Non-Demented Subjects
J. Norberg (2011)
10.1073/pnas.1109038108
Brain network local interconnectivity loss in aging APOE-4 allele carriers
Jesse A. Brown (2011)
10.1016/S1474-4422(10)70325-2
Apolipoprotein E in Alzheimer's disease and other neurological disorders
P. Verghese (2011)
10.1016/j.neuroimage.2011.08.017
Convergence and divergence of thickness correlations with diffusion connections across the human cerebral cortex
G. Gong (2012)
X Zhao (2012)
10.3389/fpsyt.2011.00077
Mapping the Alzheimer’s Brain with Connectomics
Teng Xie (2012)
10.1016/j.neurobiolaging.2013.02.020
Alzheimer's disease: connecting findings from graph theoretical studies of brain networks
B. Tijms (2013)
10.1016/j.jocn.2012.04.020
Proxies of cognitive reserve and their effects on neuropsychological performance in patients with mild cognitive impairment
Y. Liu (2013)
10.1371/journal.pone.0068910
BrainNet Viewer: A Network Visualization Tool for Human Brain Connectomics
Mingrui Xia (2013)
10.1371/journal.pone.0068860
Glucose Metabolism during Resting State Reveals Abnormal Brain Networks Organization in the Alzheimer’s Disease and Mild Cognitive Impairment
Gretel Sanabria-Diaz (2013)
10.1038/nrn3465
Imaging structural co-variance between human brain regions
A. Alexander-Bloch (2013)
10.1038/nrneurol.2012.263
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Chia-Chen Liu (2013)
EH Seo (2013)
10.3174/ajnr.A3545
Genetics of Alzheimer Disease
A. Rao (2014)
10.1016/j.neuron.2014.10.015
The Chronnectome: Time-Varying Connectivity Networks as the Next Frontier in fMRI Data Discovery
V. Calhoun (2014)
10.1523/JNEUROSCI.5072-13.2014
Intersubject Variability of and Genetic Effects on the Brain's Functional Connectivity during Infancy
W. Gao (2014)
M Daianu (2014)
10.1088/2057-1976/1/1/015001
Apolipoprotein-E4 (ApoE4) carriers show altered small-world properties in the default mode network of the brain
M. Goryawala (2015)
10.1002/ana.24369
APOEε2 is associated with milder clinical and pathological Alzheimer disease
A. Serrano-Pozo (2015)
10.1002/hbm.22740
Apolipoprotein E ε4 modulates functional brain connectome in Alzheimer's disease
Jinhui Wang (2015)
10.1001/jama.2015.4668
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
W. Jansen (2015)
Z Yao (2015)
10.1007/s12035-016-0224-5
Disrupted Brain Structural Connectivity: Pathological Interactions Between Genetic APOE ε4 Status and Developed MCI Condition
Chao Ma (2017)
10.1093/cercor/bhw128
Disrupted Network Topology in Patients with Stable and Progressive Mild Cognitive Impairment and Alzheimer's Disease
J. Pereira (2016)
10.1038/s41598-017-00432-0
APOE Genotype Effects on Intrinsic Brain Network Connectivity in Patients with Amnestic Mild Cognitive Impairment
Zan Wang (2017)
10.1016/j.neurobiolaging.2017.09.011
Gray matter networks and clinical progression in subjects with predementia Alzheimer's disease
B. Tijms (2018)
10.1002/alz.12068
2020 Alzheimer's disease facts and figures
(2020)



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