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Family History And Risk Of Lung Cancer: Age-at-diagnosis In Cases And First-degree Relatives

A. Cassidy, J. Myles, S. Duffy, T. Liloglou, J. Field
Published 2006 · Medicine

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To investigate the little known risk of lung cancer at an early age when a first-degree relative has had such a diagnosis, 579 incident cases and 1157 population controls were studied in Liverpool between 1998 and 2004 using standardised questionnaires covering demography and lifestyle. A history of lung cancer in first-degree relatives was associated with a significantly increased risk in the proband where in both individuals the cancers were diagnosed before the age of 60 years (odds ratio (OR)=4.89; 95% confidence interval (CI): 1.47–16.25). A significantly elevated risk of lung cancer was also observed in association with a relative affected before the age of 60 years, regardless of age-at-onset of the disease (OR=2.08; 95% CI: 1.20–3.59). This finding is strongly consistent with a genetic component in early-onset lung cancer risk.
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