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The MAP Kinase Substrate MKS1 Is A Regulator Of Plant Defense Responses

E. Andréasson, T. Jenkins, P. Brodersen, Stephan Thorgrimsen, Nikolaj H. T. Petersen, Shijiang Zhu, Jin-long Qiu, P. Micheelsen, A. Rocher, Morten Petersen, M. Newman, Henrik Bjørn Nielsen, H. Hirt, I. Somssich, O. Mattsson, John Mundy
Published 2005 · Biology, Medicine

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Arabidopsis MAP kinase 4 (MPK4) functions as a regulator of pathogen defense responses, because it is required for both repression of salicylic acid (SA)‐dependent resistance and for activation of jasmonate (JA)‐dependent defense gene expression. To understand MPK4 signaling mechanisms, we used yeast two‐hybrid screening to identify the MPK4 substrate MKS1. Analyses of transgenic plants and genome‐wide transcript profiling indicated that MKS1 is required for full SA‐dependent resistance in mpk4 mutants, and that overexpression of MKS1 in wild‐type plants is sufficient to activate SA‐dependent resistance, but does not interfere with induction of a defense gene by JA. Further yeast two‐hybrid screening revealed that MKS1 interacts with the WRKY transcription factors WRKY25 and WRKY33. WRKY25 and WRKY33 were shown to be in vitro substrates of MPK4, and a wrky33 knockout mutant was found to exhibit increased expression of the SA‐related defense gene PR1. MKS1 may therefore contribute to MPK4‐regulated defense activation by coupling the kinase to specific WRKY transcription factors.
This paper references
10.1016/j.cell.2004.11.052
Pheromone-Dependent Destruction of the Tec1 Transcription Factor Is Required for MAP Kinase Signaling Specificity in Yeast
M. Bao (2004)
10.1093/emboj/20.19.5400
Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4
B. Feys (2001)
10.1016/S1360-1385(00)01600-9
The WRKY superfamily of plant transcription factors.
T. Eulgem (2000)
10.1104/PP.122.4.1301
ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation.
Y. Huang (2000)
10.1105/tpc.10.6.967
A Potential Signaling Role for Profilin in Pollen of Papaver rhoeas
S. R. Clarke (1998)
The WRKY70 transcription factor: a node of convergence for jasmonate-mediated and salicylatemediated signals in plant defense
J Li (2004)
10.1105/tpc.11.8.1393
Salicylic Acid Induction–Deficient Mutants of Arabidopsis Express PR-2 and PR-5 and Accumulate High Levels of Camalexin after Pathogen Inoculation
C. Nawrath (1999)
10.1093/bioinformatics/btg405
affy - analysis of Affymetrix GeneChip data at the probe level
L. Gautier (2004)
10.1016/S1360-1385(02)02302-6
Mitogen-activated protein kinase cascades in plants: a new nomenclature.
Kazuya Ichimura (2002)
10.1073/PNAS.97.21.11655
Coordinated plant defense responses in Arabidopsis revealed by microarray analysis.
P. Schenk (2000)
10.1016/S1097-2765(00)80265-8
FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis.
L. Gómez-Gómez (2000)
10.1023/B:PLAN.0000009297.37235.4a
An Arabidopsis thaliana T-DNA mutagenized population (GABI-Kat) for flanking sequence tag-based reverse genetics
M. G. Rosso (2004)
10.1016/S1534-5807(04)00028-0
A "Whirly" transcription factor is required for salicylic acid-dependent disease resistance in Arabidopsis.
D. Desveaux (2004)
10.1016/S0092-8674(03)00429-X
Inducers of Plant Systemic Acquired Resistance Regulate NPR1 Function through Redox Changes
Zhonglin Mou (2003)
10.1016/1369-5266(88)80051-7
Resistance response physiology and signal transduction.
D. Scheel (1998)
Phosphorylation of 1aminocyclopropane1carboxylic acid synthase by MPK 6 , a stressresponsive mitogen - activated protein kinase , induces ethylene biosynthesis in Arabidopsis
Y Liu (2004)
10.1016/J.MOLCEL.2004.06.023
The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis.
M. Teige (2004)
10.1073/PNAS.0409227102
Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity.
F. Forouhar (2005)
10.1074/JBC.M307443200
A Plasma Membrane Syntaxin Is Phosphorylated in Response to the Bacterial Elicitor Flagellin*
T. Nühse (2003)
10.1105/tpc.104.026609
Phosphorylation of 1-Aminocyclopropane-1-Carboxylic Acid Synthase by MPK6, a Stress-Responsive Mitogen-Activated Protein Kinase, Induces Ethylene Biosynthesis in Arabidopsisw⃞
Y. Liu (2004)
10.1094/MPMI.2000.13.4.430
Interacting signal pathways control defense gene expression in Arabidopsis in response to cell wall-degrading enzymes from Erwinia carotovora.
C. Norman-Setterblad (2000)
10.1038/nature02258
The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes
Eulàlia de Nadal (2004)
10.1105/tpc.8.11.2033
Characterization of eds1, a mutation in Arabidopsis suppressing resistance to Peronospora parasitica specified by several different RPP genes.
J. Parker (1996)
10.1038/35107108
Isochorismate synthase is required to synthesize salicylic acid for plant defence
M. Wildermuth (2001)
10.1111/J.1365-313X.2004.02302.X
Molecular and functional characterization of Arabidopsis Cullin 3A.
M. Dieterle (2005)
10.1105/tpc.015552
Silencing of the Mitogen-Activated Protein Kinase MPK6 Compromises Disease Resistance in Arabidopsis
F. Menke (2004)
10.1093/bioinformatics/16.4.326
Automatic discovery of regulatory patterns in promoter regions based on whole cell expression data and functional annotation
L. Jensen (2000)
10.1186/gb-2001-2-8-research0032
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application
C. Li (2001)
10.1016/S1097-2765(00)80123-9
Function of hexameric RNA in packaging of bacteriophage phi 29 DNA in vitro.
F. Zhang (1998)
10.1016/S0092-8674(00)00213-0
Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance
M. Petersen (2000)
10.1093/emboj/20.20.5556
Calcium‐dependent protein kinases play an essential role in a plant defence response
T. Romeis (2001)
Molecular and functional characterization of Arabidopsis Cullin 3 A
M. Dieterle (2004)
10.1038/415977a
MAP kinase signalling cascade in Arabidopsis innate immunity
T. Asai (2002)
10.1105/tpc.016980
The WRKY70 Transcription Factor: A Node of Convergence for Jasmonate-Mediated and Salicylate-Mediated Signals in Plant Defense On-line version contains Web-only data.
J. Li (2004)
10.1186/gb-2003-4-10-r67
A high performance test of differential gene expression for oligonucleotide arrays
W. Lemon (2003)
10.1105/tpc.11.2.273
Rapid Avr9- and Cf-9–Dependent Activation of MAP Kinases in Tobacco Cell Cultures and Leaves: Convergence of Resistance Gene, Elicitor, Wound, and Salicylate Responses
T. Romeis (1999)
10.1105/tpc.012211
Salicylic Acid and NPR1 Induce the Recruitment of trans-Activating TGA Factors to a Defense Gene Promoter in Arabidopsis Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.012211.
C. Johnson (2003)
10.1105/tpc.009159
NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.009159.
S. Spoel (2003)
10.1038/sj.emboj.7600086
An extracellular aspartic protease functions in Arabidopsis disease resistance signaling
Y. Xia (2004)
10.1038/35081161
Plant pathogens and integrated defence responses to infection
J. Dangl (2001)
10.1074/JBC.275.11.7521
Microbial Elicitors Induce Activation and Dual Phosphorylation of the Arabidopsis thaliana MAPK 6*
T. Nühse (2000)
Molecular and functional characterization of Arabidopsis
M Dieterle (2005)
10.1186/gb-2002-3-9-research0048
A new non-linear normalization method for reducing variability in DNA microarray experiments
C. Workman (2002)
10.1105/tpc.104.024810
Stimulus-Dependent, Promoter-Specific Binding of Transcription Factor WRKY1 to Its Native Promoter and the Defense-Related Gene PcPR1-1 in Parsleyw⃞
F. Turck (2004)
10.1094/MPMI.2001.14.6.785
Induction of hydroxycinnamoyl-tyramine conjugates in pepper by Xanthomonas campestris, a plant defense response activated by hrp gene-dependent and hrp gene-independent mechanisms.
M. Newman (2001)
10.1046/J.1365-313X.2000.00913.X
Various abiotic stresses rapidly activate Arabidopsis MAP kinases ATMPK4 and ATMPK6.
K. Ichimura (2000)
10.1105/tpc.10.4.557
Uncoupling PR Gene Expression from NPR1 and Bacterial Resistance: Characterization of the Dominant Arabidopsis cpr6-1 Mutant
J. Clarke (1998)
10.1105/tpc.12.6.963
cDNA-AFLP Reveals a Striking Overlap in Race-Specific Resistance and Wound Response Gene Expression Profiles
W. E. Durrant (2000)
10.1016/S0968-0004(00)01627-3
Docking domains and substrate-specificity determination for MAP kinases.
A. Sharrocks (2000)
A putative lipid transfer protein involved in systemic resistance signaling
AM Maldonado (2002)
10.1046/J.1365-313X.2003.01717.X
Topology of the network integrating salicylate and jasmonate signal transduction derived from global expression phenotyping.
J. Glazebrook (2003)
10.1016/J.MOLCEL.2004.11.050
Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor.
M. Narasimhan (2005)
10.1242/jcs.01346
MAP kinases as structural adaptors and enzymatic activators in transcription complexes
J. W. Edmunds (2004)
Salicylic acid and NPR1 induce the recruitment of transactivating TGA factors to a defense gene promoter in Arabidopsis
C Johnson (2003)
10.1038/29087
Nitric oxide functions as a signal in plant disease resistance
M. Delledonne (1998)
10.1038/35077122
Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila
D. Baker (2001)
10.1038/nature00962
A putative lipid transfer protein involved in systemic resistance signalling in Arabidopsis
A. Maldonado (2002)
The jasmonate signal pathway
JG Turner (2002)
10.1016/S0014-5793(02)02388-8
Novel nuclear‐encoded proteins interacting with a plastid sigma factor, Sig1, in Arabidopsis thaliana 1
K. Morikawa (2002)
10.1046/J.1365-313X.1998.00288.X
Functional analysis of regulatory sequences controlling PR-1 gene expression in Arabidopsis.
E. Lebel (1998)
10.1038/82521
The transcriptome of Arabidopsis thaliana during systemic acquired resistance
K. Maleck (2000)
Ethylene biosynthesis and signaling networks
KL-C Wang (2002)
10.1038/ncb1056
Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases
M. Furukawa (2003)
10.1126/stke.2002.162.pe49
Hitting the Target: Emerging Technologies in the Search for Kinase Substrates
B. Manning (2002)
10.1016/S1360-1385(98)01364-8
Salicylic acid-independent plant defence pathways.
Pieterse (1999)
10.1038/nature02485
Bacterial disease resistance in Arabidopsis through flagellin perception
C. Zipfel (2004)
Phosphorylation of 1-aminocyclopropane-1carboxylic acid synthase by MPK6, a stress-responsive mitogen
Y Liu (2004)



This paper is referenced by
10.1002/9781118860526.CH5
Regulatory and Biosynthetic Mechanisms Underlying Plant Chemical Defense Responses to Biotic Stresses
William R. Chezem (2015)
10.1038/srep07981
Capsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2
Sung Un Huh (2015)
The Role of Arabidopsis Class-II TGA Transcription Factors in PAMP-mediated Defense Responses
Katja Rindermann (2010)
10.1093/nar/gkt983
GPLEXUS: enabling genome-scale gene association network reconstruction and analysis for very large-scale expression data
J. Li (2014)
10.1104/pp.16.00747
The WRKY57 Transcription Factor Affects the Expression of Jasmonate ZIM-Domain Genes Transcriptionally to Compromise Botrytis cinerea Resistance1
Yanjuan Jiang (2016)
10.1002/pmic.201400072
Proteomic and phosphoproteomic analyses of chromatin‐associated proteins from Arabidopsis thaliana
J. Bigeard (2014)
10.1038/emboj.2008.147
Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus
Jin-long Qiu (2008)
10.1111/j.1364-3703.2006.00324.x
Bioinformatic analysis of expressed sequence tags derived from a compatible Alternaria brassicicola-Brassica oleracea interaction.
R. A. Cramer (2006)
10.1371/journal.pone.0102360
The Beet Cyst Nematode Heterodera schachtii Modulates the Expression of WRKY Transcription Factors in Syncytia to Favour Its Development in Arabidopsis Roots
M. Ali (2014)
10.1104/pp.106.082487
Pathogen-Induced Arabidopsis WRKY7 Is a Transcriptional Repressor and Enhances Plant Susceptibility to Pseudomonas syringae1[W]
Kang-Chang Kim (2006)
10.1104/pp.18.00715
The Ring-Type E3 Ubiquitin Ligase JUL1 Targets the VQ-Motif Protein JAV1 to Coordinate Jasmonate Signaling1[OPEN]
M. R. M. Ali (2018)
10.1007/s10725-019-00534-x
Characterization of VQ motif-containing protein family and their expression patterns under phytohormones and abiotic stresses in melon (Cucumis melo L.)
Gaoyuan Zhang (2019)
10.3390/genes11030284
Genome-Wide Identification of the VQ Protein Gene Family of Tobacco (Nicotiana tabacum L.) and Analysis of Its Expression in Response to Phytohormones and Abiotic and Biotic Stresses
Cuihua Liu (2020)
10.1105/tpc.16.00130
MYB75 Phosphorylation by MPK4 Is Required for Light-Induced Anthocyanin Accumulation in Arabidopsis[OPEN]
Shengnan Li (2016)
10.1104/pp.112.196816
Structural and Functional Analysis of VQ Motif-Containing Proteins in Arabidopsis as Interacting Proteins of WRKY Transcription Factors1[W][OA]
Yuan Cheng (2012)
10.1111/nph.12418
The Chinese wild grapevine (Vitis pseudoreticulata) E3 ubiquitin ligase Erysiphe necator-induced RING finger protein 1 (EIRP1) activates plant defense responses by inducing proteolysis of the VpWRKY11 transcription factor.
Y. Yu (2013)
10.1111/j.1364-3703.2007.00424.x
SIPK conditions transcriptional responses unique to either bacterial or oomycete elicitation in tobacco.
H. Hall (2007)
10.1104/pp.108.121038
Global Analysis of Arabidopsis Gene Expression Uncovers a Complex Array of Changes Impacting Pathogen Response and Cell Cycle during Geminivirus Infection1[W][OA]
J. T. Ascencio-Ibáñez (2008)
10.1071/FP09136
Tomato mitogen activated protein kinases regulate the expression of extracellular invertase Lin6 in response to stress related stimuli.
T. Hyun (2010)
10.3390/ijms14035842
Structure, Function and Networks of Transcription Factors Involved in Abiotic Stress Responses
Søren Lindemose (2013)
10.1007/s00018-018-2839-3
MAP kinase signalling: interplays between plant PAMP- and effector-triggered immunity
Karen Thulasi Devendrakumar (2018)
10.14288/1.0369253
Phosphorylation of MYB75 transcription factor by MAP kinases in Arabidopsis thaliana
Anna E Kreynes (2018)
10.1105/tpc.105.037523
Physical and Functional Interactions between Pathogen-Induced Arabidopsis WRKY18, WRKY40, and WRKY60 Transcription Factors[W]
X. Xu (2006)
Analysis of the role of the HvMaPK4 gene in the barley biotic stress response
M. Abass (2011)
10.1016/j.plaphy.2019.08.019
Genome-wide analysis of the plant-specific VQ motif-containing proteins in tomato (Solanum lycopersicum) and characterization of SlVQ6 in thermotolerance.
Haidong Ding (2019)
10.1371/journal.pone.0132051
Genome-Wide Survey and Expression Profile Analysis of the Mitogen-Activated Protein Kinase (MAPK) Gene Family in Brassica rapa
Kun Lu (2015)
10.1080/07352689.2018.1441103
The WRKY Transcription Factor Family in Model Plants and Crops
F. Chen (2017)
10.1105/tpc.112.097253
The MEKK1-MKK1/MKK2-MPK4 Kinase Cascade Negatively Regulates Immunity Mediated by a Mitogen-Activated Protein Kinase Kinase Kinase in Arabidopsis[C][W]
Q. Kong (2012)
10.1016/j.bbagrm.2013.09.006
Transcriptional regulation of secondary metabolite biosynthesis in plants.
B. Patra (2013)
10.1105/tpc.106.046581
The Mitogen-Activated Protein Kinase Cascade MKK3–MPK6 Is an Important Part of the Jasmonate Signal Transduction Pathway in Arabidopsis[W][OA]
F. Takahashi (2007)
Novel Molecular Mechanisms of Arabidopsis Disease Resistance
J. Li (2007)
10.1186/gb-2007-8-4-r49
Integration of Arabidopsis thaliana stress-related transcript profiles, promoter structures, and cell-specific expression
S. Ma (2006)
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