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BZIP10‐LSD1 Antagonism Modulates Basal Defense And Cell Death In Arabidopsis Following Infection

Hironori Kaminaka, C. Näke, P. Epple, Jan Dittgen, K. Schütze, Christina Chaban, B. F. Holt, T. Merkle, E. Schäfer, K. Harter, J. Dangl
Published 2006 · Biology, Medicine

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Plants use sophisticated strategies to balance responses to oxidative stress. Programmed cell death, including the hypersensitive response (HR) associated with successful pathogen recognition, is one cellular response regulated by reactive oxygen in various cellular contexts. The Arabidopsis basic leucine zipper (bZIP) transcription factor AtbZIP10 shuttles between the nucleus and the cytoplasm and binds consensus G‐ and C‐box DNA sequences. Surprisingly, AtbZIP10 can be retained outside the nucleus by LSD1, a protein that protects Arabidopsis cells from death in the face of oxidative stress signals. We demonstrate that AtbZIP10 is a positive mediator of the uncontrolled cell death observed in lsd1 mutants. AtbZIP10 and LSD1 act antagonistically in both pathogen‐induced HR and basal defense responses. LSD1 likely functions as a cellular hub, where its interaction with AtbZIP10 and additional, as yet unidentified, proteins contributes significantly to plant oxidative stress responses.
This paper references
bZIP transcription factors in Arabidopsis
J. L. Riechmann (2002)
A novel zinc - finger protein is encoded by the Arabidopsis lsd 1 gene and functions as a negative regulator of plant
RA Dietrich (1997)
10.1093/emboj/17.24.7416
Crm1p mediates regulated nuclear export of a yeast AP‐1‐like transcription factor
C. Yan (1998)
10.1016/0092-8674(94)90218-6
Arabidopsis mutants simulating disease resistance response
R. Dietrich (1994)
10.1111/J.1365-313X.2004.02099.X
Two TIR:NB:LRR genes are required to specify resistance to Peronospora parasitica isolate Cala2 in Arabidopsis.
E. Sinapidou (2004)
10.1016/S1097-2765(02)00496-3
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation.
Chang‐Deng Hu (2002)
10.1126/science.274.5294.1853
The Metal-Insulator Transition in Correlated Disordered Systems
E. Abrahams (1996)
10.1038/ng1639
Pathogen-induced, NADPH oxidase–derived reactive oxygen intermediates suppress spread of cell death in Arabidopsis thaliana
M. A. Torres (2005)
10.1046/J.1365-313X.2003.01676.X
An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus.
O. Voinnet (2003)
10.1046/J.0014-2956.2001.02552.X
Plant bZIP G-box binding factors. Modular structure and activation mechanisms.
Y. Sibéril (2001)
10.1083/JCB.144.2.201
Nuclear Import of the Parsley bZIP Transcription Factor CPRF2 Is Regulated by Phytochrome Photoreceptors
S. Kircher (1999)
10.1126/science.273.5283.1853
Initiation of Runaway Cell Death in an Arabidopsis Mutant by Extracellular Superoxide
T. Jabs (1996)
10.1046/j.1365-2958.2002.03020.x
Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues
E. A. Castillo (2002)
Synergistic activation of seed storage protein gene expression by ABI3 and two bZIPs related to OPAQUE2
P Lara (2003)
10.1046/j.1365-313x.1992.t01-38-00999.x
Complementation of Saccharomyces cerevisiae auxotrophic mutants by Arabidopsis thaliana cDNAs.
M. Minet (1992)
10.1074/JBC.M007971200
The DNA Binding Properties of the Parsley bZIP Transcription Factor CPRF4a Are Regulated by Light*
F. Wellmer (2001)
10.1093/emboj/19.19.5157
H2O2 sensing through oxidation of the Yap1 transcription factor
A. Delaunay (2000)
Development of lsd1 rcd was observed macroscopically and by Trypan Blue staining
10.2307/2343822
Biometry: The Principles and Practice of Statistics in Biological Research
R. R. Sokal (1969)
10.1016/0092-8674(93)90498-F
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
J. Gyuris (1993)
10.1073/PNAS.0408941102
An Arabidopsis transcription factor, AtbZIP60, regulates the endoplasmic reticulum stress response in a manner unique to plants.
Y. Iwata (2005)
10.1111/J.1365-313X.2004.02219.X
Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation.
M. Walter (2004)
10.1073/pnas.1130421100
Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins
P. Epple (2003)
10.1038/4315
Selection system for genes encoding nuclear-targeted proteins
N. Ueki (1998)
H 2 O 2 sensing through oxidation of the Yap 1 transcription factor
A Delaunay (2000)
10.1074/JBC.M210538200
Synergistic Activation of Seed Storage Protein Gene Expression in Arabidopsis by ABI3 and Two bZIPs Related to OPAQUE2*
P. Lara (2003)
10.1006/EXCR.1998.4136
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1.
N. Kudo (1998)
10.1074/jbc.274.41.29476
Phosphorylation of the Parsley bZIP Transcription Factor CPRF2 Is Regulated by Light*
F. Wellmer (1999)
10.1007/s004380100502
Isolation and characterization of four novel parsley proteins that interact with the transcriptional regulators CPRF1 and CPRF2
A. Rügner (2001)
14-3-3 proteins regulate intracellular localization of the bZIP transcriptional activator RSG
D Igarashi (2001)
10.1046/J.0960-7412.2001.01225.X
Runaway cell death, but not basal disease resistance, in lsd1 is SA- and NIM1/NPR1-dependent.
D. H. Aviv (2002)
10.1104/pp.104.043646
LESION SIMULATING DISEASE 1 Is Required for Acclimation to Conditions That Promote Excess Excitation Energy12[w]
A. Mateo (2004)
10.1101/GAD.12.10.1453
Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.
W. Toone (1998)
10.1111/J.1365-313X.2004.02192.X
ABF2, an ABRE-binding bZIP factor, is an essential component of glucose signaling and its overexpression affects multiple stress tolerance.
Sunmi Kim (2004)
10.1007/s004380000400
The response regulator ARR2: a pollen-specific transcription factor involved in the expression of nuclear genes for components of mitochondrial Complex I in Arabidopsis
J. Lohrmann (2001)
10.1046/J.1365-313X.2000.00868.X
Technical advance: An estrogen receptor-based transactivator XVE mediates highly inducible gene expression in transgenic plants.
J. Zuo (2000)
10.1105/tpc.6.11.1607
Functional analysis of a light-responsive plant bZIP transcriptional regulator.
M. Feldbrügge (1994)
10.1126/SCIENCE.1114358
Integration of Spatial and Temporal Information During Floral Induction in Arabidopsis
P. Wigge (2005)
Mol Microbiol
min on ice, the DNA binding activity of AtbZIP10 in the presence of LSD1 was assayed by EMSA
Complementation assays. Four week old lsd1 mutant plants homozygous for a native promoter-LSD1-myc epitope tagged construct were sprayed with 150 µM BTH
10.1046/J.1365-313X.1998.00343.X
Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.
S. Clough (1998)
10.1046/J.1365-313X.1999.00644.X
Nuclear export of proteins in plants: AtXPO1 is the export receptor for leucine-rich nuclear export signals in Arabidopsis thaliana.
D. Haasen (1999)
10.1016/S0065-2296(08)60075-0
Symbiology of Mouse-Ear Cress (Arabidopsis Thaliana) and Oomycetes
E. Holub (1997)
10.1016/S0092-8674(00)81911-X
A Novel Zinc Finger Protein Is Encoded by the Arabidopsis LSD1 Gene and Functions as a Negative Regulator of Plant Cell Death
R. Dietrich (1997)
10.2307/2287349
Biometry: The Principles and Practice of Statistics in Biological Research (2nd ed.).
K. Bailey (1982)
10.1126/SCIENCE.1086391
Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana
J. Alonso (2003)
10.1016/S1534-5807(02)00174-0
An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis development.
B. F. Holt (2002)
proteins regulate intracellular localization of the bZIP transcriptional activator RSG
D Igarashi (2001)



This paper is referenced by
Salicylic Acid Accumulation Causes Alteration in Abscisic Acid Signaling and Induces Abscisic Acid Insensitivity in the Lesion Mimic Mutant cpr22
S. Mosher (2009)
10.1016/j.plaphy.2013.07.009
Wheat zinc finger protein TaLSD1, a negative regulator of programmed cell death, is involved in wheat resistance against stripe rust fungus.
Jun Guo (2013)
Understanding DELLA in Wheat Linking Genotype to Phenotype
Robert J. Saville (2011)
10.1007/978-1-4939-9635-3
Antiviral Resistance in Plants
Kappei Kobayashi (2019)
10.1111/j.1365-3040.2011.02323.x
A subcellular localization compendium of hydrogen peroxide-induced proteins.
Annelies Inzé (2012)
10.1111/j.1469-8137.2010.03275.x
The Arabidopsis LSD1 gene plays an important role in the regulation of low temperature-dependent cell death.
Xiaozhen Huang (2010)
10.1146/annurev-arplant-050213-040012
Effector-triggered immunity: from pathogen perception to robust defense.
H. Cui (2015)
10.1111/J.1365-313X.2007.03385.X
The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE2.
J. Hanson (2008)
10.1105/tpc.108.062968
A Pivotal Role of the Basic Leucine Zipper Transcription Factor bZIP53 in the Regulation of Arabidopsis Seed Maturation Gene Expression Based on Heterodimerization and Protein Complex Formation[W]
R. Alonso (2009)
10.1016/j.ejcb.2009.11.023
The role of phosphorylatable serine residues in the DNA-binding domain of Arabidopsis bZIP transcription factors.
Tobias Kirchler (2010)
10.1111/j.1365-313X.2012.05101.x
The Arabidopsis B-type response regulator 18 homomerizes and positively regulates cytokinin responses.
Manikandan Veerabagu (2012)
10.3390/ijms14047815
Plant bZIP Transcription Factors Responsive to Pathogens: A Review
M. Alves (2013)
Molecular analysis of importin-α-mediated nucleocytoplasmic signaling in plant innate immunity
C. Roth (2015)
10.1371/journal.pone.0211887
In-silico study of biotic and abiotic stress-related transcription factor binding sites in the promoter regions of rice germin-like protein genes
Arpita Das (2019)
10.1111/j.1469-8137.2009.02865.x
Functional redundancy in the Arabidopsis Cathepsin B gene family contributes to basal defence, the hypersensitive response and senescence.
H. McLellan (2009)
Sweet connections, bZIP transcription factors and the regulation of metabolism in Arabidopsis
M.G.M Hanssen (2009)
10.1007/s00438-015-1060-4
The phylogeny and evolutionary history of the Lesion Simulating Disease (LSD) gene family in Viridiplantae
Caroline Cabreira (2015)
10.1016/J.PMPP.2016.11.001
Differential expression of defense-related genes in chilli pepper infected with anthracnose pathogen Colletotrichum truncatum
R. Mishra (2017)
10.1371/journal.pgen.1003465
Genetic Requirements for Signaling from an Autoactive Plant NB-LRR Intracellular Innate Immune Receptor
M. Roberts (2013)
10.1104/pp.110.167569
Ascorbate and Glutathione: The Heart of the Redox Hub1
C. Foyer (2011)
10.1002/9781118867716.CH6
Transcription Factors that Regulate Defence Responses and Their Use in Increasing Disease Resistance
Prateek Tripathi (2016)
10.1002/9780470015902.A0020103.PUB2
Hypersensitive Response in Plants
Maurizio Camagna (2018)
10.1146/annurev.phyto.050908.135202
Salicylic Acid, a multifaceted hormone to combat disease.
A. Vlot (2009)
10.1111/j.1365-313X.2009.03995.x
An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis.
Mingyue Gou (2009)
10.1093/jxb/err402
Photosynthesis, photorespiration, and light signalling in defence responses.
Saijaliisa Kangasjärvi (2012)
10.1104/pp.113.225805
LESION SIMULATING DISEASE1 Interacts with Catalases to Regulate Hypersensitive Cell Death in Arabidopsis1[C][W]
Yansha Li (2013)
10.1093/bfgp/elv011
Functional studies of transcription factors involved in plant defenses in the genomics era.
Eunyoung Seo (2015)
10.1038/nature09083
Natural allelic variation underlying a major fitness tradeoff in Arabidopsis thaliana
M. Todesco (2010)
10.1007/s10142-013-0326-3
The Lesion Simulating Disease (LSD) gene family as a variable in soybean response to Phakopsora pachyrhizi infection and dehydration
Caroline Cabreira (2013)
10.3389/fpls.2013.00149
Hop-on hop-off: importin-α-guided tours to the nucleus in innate immune signaling
L. Wirthmueller (2013)
10.1007/978-3-540-87407-2_12
Programmed Cell Death in Fungus–Plant Interactions
Amir Sharon (2009)
10.1016/j.celrep.2012.05.008
The Arabidopsis NPR1 protein is a receptor for the plant defense hormone salicylic acid.
Y. Wu (2012)
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