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Persistence Of Abnormal Neural Responses To A Meal In Postobese Individuals

A. Delparigi, K. Chen, A D Salbe, J. Hill, R. Wing, E M Reiman, P A Tataranni
Published 2004 · Medicine

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OBJECTIVE: To determine whether abnormal obese-like neural responses to a meal persist in postobese individuals, who achieved and maintained a normal body weight despite a past history of severe obesity.DESIGN AND SUBJECTS: Cross-sectional study of the brain's response to tasting and consuming a satiating meal in 11 postobese (age: 40±6 y, body mass index (BMI): 23.6±1.9 kg/m2), 23 obese (age: 29±6 y, BMI: 39.6±3.8 kg/m2) and 21 lean (age: 33±9 y, BMI: 22.8±2.1 kg/m2) subjects.MEASUREMENTS: Regional cerebral blood flow (rCBF, a marker of neural activity) at baseline (after a 36-h fast), after tasting and after consuming a satiating liquid meal was assessed using positron emission tomography and state-dependent changes (taste-baseline; satiation-baseline), and compared across groups. Subjective ratings of hunger and fullness were measured by a visual analogue scale and body fatness by dual-energy X-ray absorptiometry.RESULTS: In response to tasting the liquid meal, changes in rCBF were different in the obese as compared to the lean individuals (P<0.05, corrected for multiple comparisons) in the middle insula (peak voxel, x=−41, y=1, z=8; Montreal Neurological Institute coordinates) and posterior cingulate cortex (peak voxel, x=17, y=−47, z=40). The middle insular cortex exhibited a similar increase of neural activity in the obese and postobese subjects, whereas in the lean subjects the regional activity did not change. In the posterior cingulate cortex, the changes in rCBF in the postobese subjects were not different from those in the other groups. In response to a satiating amount of the same liquid meal, changes in rCBF were different in the obese as compared to the lean individuals (P<0.05, corrected for multiple comparisons) in the posterior hippocampus (peak voxel, x=21, y=−45, x=4), posterior cingulate cortex (peak voxel, x=17, y=−47, z=40), and amygdala (peak voxel, x=27, y=1, z=−24). The posterior hippocampus exhibited a similar decrease of neural activity in the obese and postobese subjects, whereas in the lean subjects the regional activity increased. In the posterior cingulate cortex and amygdala, the changes in rCBF were not different between the postobese and lean individuals. None of the changes in neural activity were correlated with the age of the individuals, the subjective ratings of hunger and fullness, or the meal induced-changes in plasma glucose, insulin, or serum free fatty acids.CONCLUSION: Persistence of abnormal neural responses to a meal in the postobese individuals, a group at high risk for relapse, indicates that a predisposition to obesity may involve areas of the brain that control complex aspects of eating behavior including anticipation and reward, chemosensory perception, and autonomic control of digestion (insular cortex), as well as enteroception and learning/memory (hippocampus).
This paper references
The temporal response of the brain after eating revealed by functional MRI
Y. Liu (2000)
Sensory‐specific satiety‐related olfactory activation of the human orbitofrontal cortex
J. O'Doherty (2000)
Electrical stimulation of the insular cortex induces flavor-preferences in rats
I. Cubero (2000)
Altered hypothalamic function in response to glucose ingestion in obese humans.
M. Matsuda (1999)
Differential brain responses to satiation in obese and lean men.
J. Gautier (2000)
Enhanced Food-Anticipatory Circadian Rhythms in the Genetically Obese Zucker Rat
R. Mistlberger (1999)
Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex.
J. O'Doherty (2000)
Insulin receptor substrate-1 (IRS-1) expression in rat brain.
D. Baskin (1994)
The hippocampus and motivation revisited: appetite and activity
A. Tracy (2001)
Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography.
P. A. Tataranni (1999)
Changes in brain activity related to eating chocolate: from pleasure to aversion.
D. Small (2001)
Mental phenomena induced by stimulation in the limbic system.
E. Halgren (1982)
Insulin inhibits pyramidal neurons in hippocampal slices
R. Palovcik (1984)
Identification of the cerebral loci processing human swallowing with H2(15)O PET activation.
S. Hamdy (1999)
Regional brain metabolic activation during craving elicited by recall of previous drug experiences.
G. Wang (1999)
PET shows that odors are processed both ipsilaterally and contralaterally to the stimulated nostril
I. Savic (2000)
Quantitative genetics of energy balance--lessons from animal models.
D. Pomp (1999)
Neuroimaging and Obesity
A. D. Parigi (2002)
Functional localization and lateralization of human olfactory cortex
R. Zatorre (1992)
Food reward: Brain substrates of wanting and liking
K. Berridge (1996)
Hormones and the hippocampus.
R. Lathe (2001)
Organization of visceral and limbic connections in the insular cortex of the rat
G. V. Allen (1991)
Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.
L. Squire (1992)
Human cortical gustatory areas: a review of functional neuroimaging data.
D. Small (1999)
Taste as a factor in the management of nutrition.
T. Scott (2000)
Flavor processing: more than the sum of its parts
D. Small (1997)
The insula; further observations on its function.
W. Penfield (1955)
Sensory - specific satietyrelated olfactory activation of the human orbitofrontal cortex [ corrected and republished article originally printed in
ET Rolls (2000)
The role of the agranular insular cortex in working memory for food reward value and allocentric space in rats
M. Ragozzino (1998)
Cephalic phase, reflex insulin secretion
HR Berthoud (1981)
The effect of taste on gastric and pancreatic responses in dogs
M. A. Powers (1990)
Cephalic phase, reflex insulin secretion. Neuroanatomical and physiological characterization.
H. R. Berthoud (1981)
FMRI Visualization of Brain Activity during a Monetary Incentive Delay Task
Brian Knutson (2000)
Central nervous system control of food intake
M. Schwartz (2000)
Exaggerated pancreatic polypeptide secretion in Pima Indians: can an increased parasympathetic drive to the pancreas contribute to hyperinsulinemia, obesity, and diabetes in humans?
C. Weyer (2001)
Involvement of the cholinergic system in insulin and glucagon oversecretion of genetic preobesity.
F. Rohner-Jeanrenaud (1985)
Circuitry and functional aspects of the insular lobe in primates including humans
J. Augustine (1996)
Epidemiology of obesity in relation to nutrient intake.
M. Gibney (1995)
Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst.
D. Denton (1999)
Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomography.
A. Del Parigi (2002)
Regions of the human brain affected during a liquid-meal taste perception in the fasting state: a positron emission tomography study.
J. Gautier (1999)
Direct effect of CNS on insulin hypersecretion in obese Zucker rats: involvement of vagus nerve.
H. C. Lee (1989)
Mapping human visual cortex with positron emission tomography
P. Fox (1986)
Successful weight loss maintenance.
R. Wing (2001)
fMRI activation in response to odorants orally delivered in aqueous solutions.
B. Cerf-Ducastel (2001)
Effect of satiation on brain activity in obese and lean women.
J. Gautier (2001)
PET study of the localization and laterality of lingual somatosensory processing in humans
J. Pardo (1997)
Role of the brain in energy balance and obesity.
B. Levin (1996)
Early phase insulin infusion and muscarinic blockade in obese and lean subjects.
K. Teff (1999)
Brain's response to a meal in postobese individuals A DelParigi et al
Breathlessness in humans activates insular cortex
R. Banzett (2000)
Cortical Processing of Human Somatic and Visceral Sensation
Q. Aziz (2000)
Little and often: ingestive behavior patterns following hippocampal lesions in rats.
P. G. Clifton (1998)

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Human Eating Motivation in Times of Plenty: Biological, Environmental, and Psychosocial Influences
M. Lowe (2008)
Altered gastric vagal mechanosensitivity in diet-induced obesity persists on return to normal chow and is accompanied by increased food intake
S. Kentish (2014)
Orosensory and Homeostatic Functions of the Insular Taste Cortex
I. E. Araújo (2012)
The Brain, the Environment, and Human Obesity: An Evolutionary Perspective on the Difficulty with Maintaining Long-Term Weight Loss
B. King (2017)
Effect of combined naltrexone and bupropion therapy on the brain's reactivity to food cues
G. Wang (2014)
Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger
Sarah Nolan-Poupart (2013)
Neural mechanisms underlying food motivation in children and adolescents
L. Holsen (2005)
PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
R. Batterham (2007)
Neuroimaging in eating disorders and obesity: implications for research.
F. van den Eynde (2009)
Etiology and Pathophysiology / Diagnostics Neuroimaging and obesity : current knowledge and future directions
S. Carnell (2011)
Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry
G. Wang (2006)
The Lighter Side of Bdnf 4 5
E. Noble (2011)
Leptin reverses declines in satiation in weight-reduced obese humans.
H. Kissileff (2012)
Functional Magnetic Resonance Imaging in Awake Rats: Studies Relevant to Addiction and the Reward Circuitry
Marcelo Febo (2013)
The lighter side of BDNF.
E. Noble (2011)
Addictive Aspects of Eating Disorders and Obesity
Youl Ri Kim (2012)
Identification of Novel Mechanisms in the Hypothalamus Linked to Adiposity.
M. S. Byerly (2007)
Brain regulation of food intake and appetite: molecules and networks
C. Broberger (2005)
Neural response to catecholamine depletion in remitted bulimia nervosa: Relation to depression and relapse
Stefanie Verena Mueller (2017)
Increased Neural Processing of Rewarding and Aversive Food Stimuli in Recovered Anorexia Nervosa
F. Cowdrey (2011)
Targeting thermogenesis and related pathways in anti-obesity drug discovery.
J. Clapham (2011)
Regulation of Weight in Prader-Willi Syndrome: Theoretical and Practical Considerations
L. Gourash (2009)
Differences in the neuronal response to food in obesity-resistant as compared to obesity-prone individuals
Marc-Andre Cornier (2013)
Eating behaviour and neural representations of hunger and satiety in patients with acquired structural hypothalamic damage : a clinical and functional neuroimaging study
C. Steele (2018)
Neuroscience and Biobehavioral Reviews
Gabi Shefer (2013)
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
A. Boveris (2007)
Individual differences in the neurophysiology of reward and the obesity epidemic
D. Small (2009)
Increased dorsolateral prefrontal cortex activation in obese children during observation of food stimuli
S. Davids (2010)
Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation
Terry L. Davidson (2009)
Food Addiction and Cues in Prader-Willi Syndrome
K. V. Von Deneen (2009)
Individual differences in the propensity of female rhesus monkeys (Macaca mulatta) to gain and lose body weight
E. L. Sullivan (2006)
Title : Association analyses for dopamine receptor gene polymorphisms and weight status : a cross-sectional case-control study and longitudinal analysis in obese children before and after lifestyle intervention Running title : Dopamine receptor polymorphisms and obesity
De (2013)
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