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Survivin, Versatile Modulation Of Cell Division And Apoptosis In Cancer

D. Altieri
Published 2003 · Biology, Medicine

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Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation of sister chromatids and timely separation of daughter cells. Investigators interested in mechanisms of apoptosis have found survivin an evolving challenge: while survivin inhibits apoptosis in vitro and in vivo, this pathway may be more selective as compared to cytoprotection mediated by other IAPs. Finally, basic and translational researchers in cancer biology have converged on survivin as a pivotal cancer gene, not simply for its sharp expression in tumors and not in normal tissues, but also for the potential exploitation of this pathway in cancer diagnosis and therapy. The objective of the present contribution is to line up current evidence and emerging concepts on the multifaceted functions of survivin in cell death and cell division, and how this pathway is being pursued for novel cancer therapeutic strategies.
This paper references
10.1177/001452469000101110
"J."
G. G. Stokes (1890)
10.1016/0092-8674(93)90586-F
Cell
AC Tose (1993)
Nat
G Ambrosini (1997)
10.1038/25141
Control of apoptosis and mitotic spindle checkpoint by survivin
F. Li (1998)
10.1126/SCIENCE.281.5376.533
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
N. Gray (1998)
10.1016/S0140-6736(05)70294-4
Anti-apoptosis gene, survivin, and prognosis of neuroblastoma
C. Adida (1998)
Mol
D Yu (1998)
Am
C Adida (1998)
10.1073/PNAS.96.18.10170
Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division.
A. Uren (1999)
10.1056/NEJM199908053410614
Tumor content of the antiapoptosis molecule survivin and recurrence of bladder cancer.
H. Swana (1999)
10.1042/BJ3440305
Transcriptional analysis of human survivin gene expression.
F. Li (1999)
10.1046/J.1523-1747.1999.00776.X
Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma.
D. Grossman (1999)
10.1006/BBRC.1999.1589
Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells.
J. Tran (1999)
10.1073/PNAS.96.4.1457
Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation.
K. Kobayashi (1999)
Int
Y Saitoh (1999)
Biochem
J Tran (1999)
N
HS Swana (1999)
Biochem
F Li (1999)
Nat
F Li (1999)
Proc
K Kobayashi (1999)
Nat
W Zhou (1999)
Curr
AG Fraser (1999)
10.1073/PNAS.240390697
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.
D. S. O'Connor (2000)
10.1016/S0092-8674(00)00008-8
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
C. Du (2000)
10.1038/SJ.NEO.7900091
Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth.
J. Chen (2000)
10.1136/gut.46.5.645
Expression of the antiapoptosis gene,Survivin, predicts death from recurrent colorectal carcinoma
A. Sarela (2000)
10.1074/jbc.M000369200
Deterin, a New Inhibitor of Apoptosis from Drosophila melanogaster *
G. Jones (2000)
10.1038/sj.onc.1203358
High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma
A. Islam (2000)
10.1038/77929
Structural basis for phosphoserine-proline recognition by group IV WW domains
M. Verdecia (2000)
10.1046/J.1365-2141.2000.02328.X
Expression and prognostic significance of survivin in de novo acute myeloid leukaemia
C. Adida (2000)
10.1083/JCB.151.7.1575
Human Survivin Is a Kinetochore-Associated Passenger Protein
D. Skoufias (2000)
10.1016/S0092-8674(00)81683-9
The Hallmarks of Cancer
D. Hanahan (2000)
10.1038/sj.onc.1203429
Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death
A. Suzuki (2000)
10.1016/S0002-9440(10)64742-6
Control of apoptosis during angiogenesis by survivin expression in endothelial cells.
D. S. O'Connor (2000)
10.1074/JBC.275.13.9102
Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway*
A. Papapetropoulos (2000)
10.1038/sj.onc.1204086
STAT proteins: novel molecular targets for cancer drug discovery
J. Turkson (2000)
10.1182/BLOOD.V95.4.1435.004K01_1435_1442
Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions.
E. Conway (2000)
10.1182/BLOOD.V96.12.4002.H8004000C_4002_4003
Survivin does not inhibit caspase-3 activity.
D. Banks (2000)
Clin
K Tanaka (2000)
Nat
F Khuri (2000)
Mol
C Badie (2000)
Curr
AG Uren (2000)
Br
C Adida (2000)
Mol
SW Muchmore (2000)
Mol
L Chantalat (2000)
Mol
EK Speliotes (2000)
Nat
MA Verdecia (2000)
10.1172/JCI13345
Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.
D. Grossman (2001)
10.1002/jcb.1228
Participation of Survivin in mitotic and apoptotic activities of normal and tumor‐derived cells *
X. Jiang (2001)
10.1073/PNAS.98.4.1543
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1.
Y. Shen (2001)
10.1016/S0002-9440(10)64131-4
Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting.
M. Mesri (2001)
10.1038/35077213
Proliferation, cell cycle and apoptosis in cancer
G. Evan (2001)
10.1093/JNCI/93.20.1541
Effects of survivin antagonists on growth of established tumors and B7-1 immunogene therapy.
J. Kanwar (2001)
10.1073/PNAS.98.2.635
Inhibition of melanoma tumor growth in vivo by survivin targeting.
D. Grossman (2001)
10.1182/BLOOD.V98.7.2091
Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34(+) cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis.
S. Fukuda (2001)
10.1046/j.1471-4159.2001.00596.x
Survivin inhibition induces human neural tumor cell death through caspase‐independent and ‐dependent pathways
S. L. Shankar (2001)
10.1046/j.1365-2141.2001.02902.x
Aberrant expression of caspase cascade regulatory genes in adult T‐cell leukaemia: survivin is an important determinant for prognosis
S. Kamihira (2001)
10.1021/BI001603Q
An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7.
S. Shin (2001)
10.1002/1097-0142(20010715)92:2<271::AID-CNCR1319>3.0.CO;2-0
Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors
Kimihiko Satoh (2001)
10.1074/JBC.M003670200
Livin, a Novel Inhibitor of Apoptosis Protein Family Member*
G. M. Kasof (2001)
10.1182/BLOOD.V97.9.2784
Cytokine-regulated expression of survivin in myeloid leukemia.
B. Carter (2001)
Proc
Y Shen (2001)
Clin
A Yagihashi (2001)
Proc
D Grossman (2001)
Int
H Yoshida (2001)
Curr
SP Wheatley (2001)
Int
J Kato (2001)
Hum
R Gianani (2001)
Am
M Mesri (2001)
Lab
K Mahboubi (2001)
Br
S Kamihira (2001)
10.1016/S1535-6108(02)00084-3
A p34(cdc2) survival checkpoint in cancer.
D. S. O'Connor (2002)
10.1200/JCO.20.4.1063
Quantitatively determined survivin expression levels are of prognostic value in human gliomas.
A. Chakravarti (2002)
10.1038/415530a
Gene expression profiling predicts clinical outcome of breast cancer
L. J. Veer (2002)
10.1038/nrm830
Apoptosis: IAP proteins: blocking the road to death's door
G. Salvesen (2002)
10.1124/JPET.102.037192
DNA Damage Induces a Novel p53-Survivin Signaling Pathway Regulating Cell Cycle and Apoptosis in Acute Lymphoblastic Leukemia Cells
Muxiang Zhou (2002)
10.1038/sj.onc.1205353
Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway
A. Mirza (2002)
10.1200/JCO.2002.08.080
Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumors.
G. Schwartz (2002)
10.1053/GAST.2002.34753
Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways.
E. Conway (2002)
10.1093/JNCI/94.7.522
Activation of cancer-specific gene expression by the survivin promoter.
R. Bao (2002)
10.1073/pnas.072586399
A role for survivin in chemoresistance of endothelial cells mediated by VEGF
J. Tran (2002)
10.1074/JBC.M106643200
Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53*
W. H. Hoffman (2002)
10.1007/s00018-002-8518-3
Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer
N. Zaffaroni (2002)
10.1016/S0092-8674(02)01014-0
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
M. Wetering (2002)
10.1038/sj.leu.2402427
Relationship between expression of genes involved in cell cycle control and apoptosis in diffuse large B cell lymphoma: a preferential survivin–cyclin B link
F. Kuttler (2002)
10.1038/sj.bjc.6600546
survivin messenger RNA expression is a good prognostic biomarker for oesophageal carcinoma
M. Ikeguchi (2002)
10.1182/BLOOD.V100.7.2463
The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34(+) cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells.
S. Fukuda (2002)
10.1016/S0140-6736(02)07990-4
Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma
P. Würl (2002)
Histol
MH Andersen (2002)
Eur
T Yamamoto (2002)
Eur
CA Koch (2002)
Curr
JB Shannon (2002)
Mol
MA Bolton (2002)
Microvasc
R Harfouche (2002)
Proc
J Tran (2002)
Exp
JA Rodriguez (2002)
Nat
GS Salvesen (2002)
Mol
C Xia (2002)
Trends Mol
Sausville EA. (2002)
Dev
CR Murphy (2002)
Clin
Y Hirohashi (2002)
Mol
Y. Shi (2002)
Clin
M Ikeguchi (2002)
Br
M Ikeguchi (2002)
10.1038/sj.bjc.6600696
Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma
P. Grabowski (2003)
Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens.
J. Zhang (2003)
10.1182/BLOOD-2002-07-2130
Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma.
Y. Aoki (2003)
10.1002/cncr.11122
Expression of survivin in astrocytic tumors
Y. Kajiwara (2003)
10.1097/01.JU.0000063685.29339.24
Effect of intravesical treatment of transitional cell carcinoma with bacillus Calmette-Guerin and mitomycin C on urinary survivin levels and outcome.
D. Hausladen (2003)
10.1046/J.1523-1747.2003.12082.X
Radiosensitization of human melanoma cells by ribozyme-mediated inhibition of survivin expression.
M. Pennati (2003)
10.1200/JCO.2003.08.066
Survivin, bcl-2, bax, and bcl-X gene expression in sentinel lymph nodes from melanoma patients.
A. Gradilone (2003)
10.1074/JBC.M211119200
Survivin Enhances Aurora-B Kinase Activity and Localizes Aurora-B in Human Cells*
J. Chen (2003)
10.1182/BLOOD-2002-08-2554
Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells.
S. M. Schmidt (2003)
Br
P Grabowski (2003)
Cancer Epidemiol
JY Zhang (2003)
Int
A Badran (2003)
Nat
Altieri DC. (2003)
Clin
NS Williams (2003)



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10.1186/s12885-021-08170-3
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Liu-Qing Zhou (2021)
10.1016/j.isci.2021.102320
PLK1-mediated S369 phosphorylation of RIPK3 during G2 and M phases enables its ripoptosome incorporation and activity
Kartik Gupta (2021)
10.1007/s10637-021-01066-w
AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axis
J. Carlos (2021)
10.3390/cancers13174497
Development of Multi-Scale X-ray Fluorescence Tomography for Examination of Nanocomposite-Treated Biological Samples
Si Chen (2021)
10.1515/HMBCI-2020-0051
Genetic variants and risk of thyroid cancer among Iranian patients
Mohammad Jamshidi (2021)
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Liu-Qing Zhou (2021)
10.1016/j.autrev.2021.102795
Endometriosis and autoimmunity: Can autoantibodies be used as a non-invasive early diagnostic tool?
H. Greenbaum (2021)
10.48083/TNGM4076
Promising Biomarkers in Renal Cell Carcinoma
J. Kapoor (2021)
10.1039/D1BM00185J
Phenylboronic acid-functionalized polyaminoglycoside as an effective CRISPR/Cas9 delivery system
Meiyu Shao (2021)
10.1016/j.jconrel.2021.03.030
Charge-reversal nanocomolexes-based CRISPR/Cas9 delivery system for loss-of-function oncogene editing in hepatocellular carcinoma.
Jing-Jun Nie (2021)
10.3389/froh.2021.676643
Targeting Stress-Response Pathways and Therapeutic Resistance in Head and Neck Cancer
T. Bos (2021)
10.3390/app11010460
Chemotherapy-Induced Survivin Regulation in Acute Myeloid Leukemia Cells
P. Otevřelová (2021)
10.1007/s42399-021-01052-6
Survivin and Caspase-3 Cannot Predict Recurrence for Urinary Bladder Carcinoma
Vivian G. D. Rouston (2021)
10.3892/ol.2020.11690
Expression of anti-apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression
A. Stavropoulos (2020)
10.2217/lmt-2020-0009
Identification of nine key genes by bioinformatics analysis for predicting poor prognosis in smoking-induced lung adenocarcinoma
Chuanli Ren (2020)
10.3390/jcm9072066
Global Gene Expression Characterization of Circulating Tumor Cells in Metastasic Castration-Resistant Prostate Cancer Patients
L. León-Mateos (2020)
10.3892/ol.2019.11227
Diagnostic accuracy of urinary survivin mRNA expression detected by RT-PCR compared with urine cytology in the detection of bladder cancer: A meta-analysis of diagnostic test accuracy in head-to-head studies
Liang Fu (2020)
10.3892/ol.2020.12258
Immunohistochemical expression of insulin-like growth factor-1Ec in primary endometrial carcinoma: Association with PTEN, p53 and survivin expression
A. Stavropoulos (2020)
10.1016/j.canlet.2020.08.002
Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma.
Shi-He Liu (2020)
10.1002/bab.2000
USP47 promotes apoptosis in rat myocardial cells after ischemia/reperfusion injury via NF‐κB activation
Yu Hu (2020)
10.1186/s13046-020-01581-3
Sur-X, a novel peptide, kills colorectal cancer cells by targeting survivin-XIAP complex
Wan-xia Fang (2020)
10.1016/j.ygeno.2020.09.053
Unraveling novel survivin mRNA transcripts in cancer cells using an in-house developed targeted high-throughput sequencing approach.
Panagiotis G Adamopoulos (2020)
10.1016/j.bios.2020.112515
Smartphone-assisted detection of nucleic acids by light-harvesting FRET-based nanoprobe.
Caterina Severi (2020)
10.1016/j.jconrel.2020.07.013
TRAIL therapy and prospective developments for cancer treatment.
Bindu Thapa (2020)
10.1007/s11095-020-2770-9
Enabling Combinatorial siRNA Delivery against Apoptosis-Related Proteins with Linoleic Acid and α-Linoleic Acid Substituted Low Molecular Weight Polyethylenimines
Samarwadee Plianwong (2020)
10.3389/fonc.2020.573141
Significance of Tumor Mutation Burden in Immune Infiltration and Prognosis in Cutaneous Melanoma
K. Kang (2020)
10.18585/inabj.v12i1.813
Survivin and Telomerase as Radiotherapeutic Response Predictors of Subjects with Stage IIIB Cervical Squamous Cell Carcinoma
F. Kusuma (2020)
Vitamin D3 (1,25(OH)2D3) ile İşlenmiş HL-60 Hücrelerindeki Gen Anlatımının Zamana Karşı Değişiminin Q-RT-PCR ile Analizi
A. Kanli (2020)
10.1002/advs.202001424
A Lactose‐Derived CRISPR/Cas9 Delivery System for Efficient Genome Editing In Vivo to Treat Orthotopic Hepatocellular Carcinoma
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Poly ( amido-amine ) Dendrimers-Based Nanomedicine for Combination Therapy with siRNA and Chemotherapeutics to Overcome Multidrug Resistance in Cancer
Jiayi Pan (2020)
10.17219/acem/123350
Monocyte chemoattractant protein-1, macrophage colony stimulating factor, survivin, and tissue inhibitor of matrix metalloproteinases-2 in analysis of damage and repair related to pediatric chronic kidney injury.
K. Musiał (2020)
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