← Back to Search
Antimicrobial Activity Of Iron Oxide Nanoparticle Upon Modulation Of Nanoparticle-bacteria Interface
Manoranjan Arakha, S. Pal, Devyani Samantarrai, T. K. Panigrahi, Bairagi C. Mallick, K. Pramanik, Bibekanand Mallick, S. Jha
Published 2015 · Chemistry, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Investigating the interaction patterns at nano-bio interface is a key challenge for safe use of nanoparticles (NPs) to any biological system. The study intends to explore the role of interaction pattern at the iron oxide nanoparticle (IONP)-bacteria interface affecting antimicrobial propensity of IONP. To this end, IONP with magnetite like atomic arrangement and negative surface potential (n-IONP) was synthesized by co-precipitation method. Positively charged chitosan molecule coating was used to reverse the surface potential of n-IONP, i.e. positive surface potential IONP (p-IONP). The comparative data from fourier transform infrared spectroscope, XRD, and zeta potential analyzer indicated the successful coating of IONP surface with chitosan molecule. Additionally, the nanocrystals obtained were found to have spherical size with 10–20 nm diameter. The BacLight fluorescence assay, bacterial growth kinetic and colony forming unit studies indicated that n-IONP (<50 μM) has insignificant antimicrobial activity against Bacillus subtilis and Escherichia coli. However, coating with chitosan molecule resulted significant increase in antimicrobial propensity of IONP. Additionally, the assay to study reactive oxygen species (ROS) indicated relatively higher ROS production upon p-IONP treatment of the bacteria. The data, altogether, indicated that the chitosan coating of IONP result in interface that enhances ROS production, hence the antimicrobial activity.
This paper references
Scientific RepoRts | 5:14813 | DOi: 10
Synthesis, Surface Modification and Characterisation of Biocompatible Magnetic Iron Oxide Nanoparticles for Biomedical Applications
Mahnaz Mahdavi (2013)
Enhanced antibacterial activity of iron oxide magnetic nanoparticles treated with Argemone mexicana L. leaf extract: An in vitro study
S. Arokiyaraj (2013)
Metabolic Sources of Hydrogen Peroxide in Aerobically Growing Escherichia coli(*)
B. González-Flecha (1995)
Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan
B. Stephen Inbaraj (2012)
Preparation and characterization of carboxyl-group functionalized superparamagnetic nanoparticles and t he potential for bio-applications
Zhi Shan (2007)
A self-assembled polydopamine film on the surface of magnetic nanoparticles for specific capture of protein.
M. Zhang (2012)
Carboxyl group (–CO2H) functionalized ferrimagnetic iron oxide nanoparticles for potential bio-applications
S. Yu (2004)
Fe3O4 inverse spinal super paramagnetic nanoparticles
O. Rahman (2012)
Synthesis of three-dimensional calcium carbonate nanofibrous structure from eggshell using femtosecond laser ablation
A. Tavangar (2011)
Synthesis and Antibacterial and Antibiofilm Activity of Iron Oxide Glycerol Nanoparticles Obtained by Coprecipitation Method
S. Iconaru (2013)
Preparation and assessment of chitosan-coated superparamagnetic Fe3O4 nanoparticles for controlled delivery of methotrexate
S. Mohammadi-Samani (2013)
Optimization of preparation of chitosan-coated iron oxide nanoparticles for biomedical applications by chemometrics approaches
S. Honary (2013)
Effect of iron oxide and gold nanoparticles on bacterial growth leading towards biological application
S. Chatterjee (2011)
How Escherichia coli tolerates profuse hydrogen peroxide formation by a catabolic pathway.
Sripriya Ravindra Kumar (2013)
Biofunctional magnetic nanoparticles for protein separation and pathogen detection.
Hongwei Gu (2006)
Porous fluorinated SnO(2) hollow nanospheres: transformative self-assembly and photocatalytic inactivation of bacteria.
Sheng-wei Liu (2014)
Comprehensive design of carbon-encapsulated Fe3O4 nanocrystals and their lithium storage properties.
Kyeongse Song (2012)
Synthesis of Silver Nanoparticles from Microbial Source-A Green Synthesis Approach, and Evaluation of its Antimicrobial Activity against Escherichia coli
S. S. Behera (2012)
Chemical stability of metallic nanoparticles: a parameter controlling their potential cellular toxicity in vitro.
M. Auffan (2009)
Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors.
A. Gupta (2004)
Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery
S. Bucak (2012)
Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus
N. Tran (2010)
Iron oxide nanoparticles induce Pseudomonas aeruginosa growth, induce biofilm formation, and inhibit antimicrobial peptide function.
Jennifer A. Borcherding (2014)
Surface modification of magnetic nanoparticle via Cu(I)-catalyzed alkyne-azide [2 + 3] cycloaddition.
P. Lin (2007)
Chitosan-Coated Ferrite (Fe3O4) Nanoparticles as a T2 Contrast Agent for Magnetic Resonance Imaging
I. Rhee (2010)
Interaction between oxide nanoparticles and biomolecules of the bacterial cell envelope as examined by infrared spectroscopy.
W. Jiang (2010)
Mechanism of Amylin Fibrillization Enhancement by Heparin*
S. Jha (2011)
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Gozde Unsoy (2012)
influence on fibroblasts in vitro
C. C. Berry (2003)
Rourkela, Odisha, India, for providing facilities like the FESEM and XRD respectively, for fulfilment of the research work. We are also thankful to Dr
Magnetic properties of electron-doped La0.23Ca0.77MnO3 nanoparticles
V. Markovich (2012)
Rapid Nanoparticle-Mediated Monitoring of Bacterial Metabolic Activity and Assessment of Antimicrobial Susceptibility in Blood with Magnetic Relaxation
C. Kaittanis (2008)
Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles.
M. Mahmoudi (2012)
An In-Vitro Study
M. Kheur (2016)
Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro.
C. Berry (2003)
Effect of Fe(3)O(4) magnetic nanoparticles on lysozyme amyloid aggregation.
Andrea Bellova (2010)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
Carboxyl group (–CO 2 H) functionalized ferrimagnetic iron oxide nanoparticles for potential bioapplications
S Yu (2004)
Magnetic nanoparticles as targeted delivery systems in oncology
Sara Prijic (2011)
Effect of aspect ratio and surface defects on the photocatalytic activity of ZnO nanorods
X. Zhang (2014)
Why chronic wounds will not heal: a novel hypothesis
T. Bjarnsholt (2008)
Sonochemical synthesis of highly luminescent zinc oxide nanoparticles doped with magnesium(II).
H. Xiong (2009)
Reactive Oxygen Species Mediated Bacterial Biofilm Inhibition via Zinc Oxide Nanoparticles and Their Statistical Determination
S. Dwivedi (2014)
2,7‐Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation
H. Possel (1997)
a novel hypothesis
Understanding biophysicochemical interactions at the nano-bio interface.
A. Nel (2009)
Study on antimicrobial activity of chitosan with different molecular weights
lian-ying Zheng (2003)
The effects of interfacial potential on antimicrobial propensity of ZnO nanoparticle
Manoranjan Arakha (2015)
This paper is referenced by
Essential Metal-Based Nanoparticles (Copper/Iron NPs) as Potent Nematicidal Agents against Meloidogyne spp.
G. Ch (2019)
Novelty of Bioengineered Iron Nanoparticles in Nanocoated Surgical Cotton: A Green Chemistry
Bhavika Turakhia (2019)
Doxycycline functionalized polymeric nanoparticles inhibit Enterococcus faecalis biofilm formation on dentine.
T. Arias-Moliz (2020)
Water vapor dehumidification using thin-film nanocomposite membranes by the in situ formation of ultrasmall size iron-chelated nanoparticles
Ali M Abou-Elanwar (2021)
Green synthesis of silver nanoparticles by Ricinus communis var. carmencita leaf extract and its antibacterial study
Sunita Ojha (2017)
Research advances in preparation and application of chitosan Nanofluorescent probes.
P. Liu (2020)
Apple pectin supported superparamagnetic (γ-Fe2O3) maghemite nanoparticles with antimicrobial potency
P. Rana (2019)
Iron and zinc ions, potent weapons against multidrug-resistant bacteria
Q. Ye (2020)
Effect of ZnONP Surface Defects on Cytotoxic and Antimicrobial Propensities
Manoranjan Arakha (2018)
Photo Catalytic, Antimicrobial and Antifungal Activity of Biogenic Iron Oxide Nanoparticles Synthesised Using Aegle marmelos Extracts
Mohana Sriramulu (2020)
Toxicity evaluation of barium ferrite nanoparticles in bacteria, yeast and nematode.
Lilibette Alvino (2020)
Preparation and Evaluation of the Antibacterial Effect of Magnetic Nanoparticles Containing Gentamicin: A Preliminary In vitro Study
Banafsheh Douzandeh-Mobarrez (2018)
Use of nanotechnology in antimicrobial therapy
N. Gupta (2019)
Green biosynthesis of magnetic iron oxide (Fe3O4) nanoparticles using the aqueous extracts of food processing wastes under photo-catalyzed condition and investigation of their antimicrobial and antioxidant activity.
J. Patra (2017)
Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles
Rania I Shebl (2017)
Antibacterial magnetic nanoparticles for therapeutics: a review.
A. Allafchian (2019)
Extracellular biosynthesis of bactericidal Ag/AgCl nanoparticles for crop protection using the fungus Macrophomina phaseolina.
Federico N. Spagnoletti (2019)
Application of Nanoparticles in Drug Delivery
I. Chattopadhyay (2020)
Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance
M. Kumar (2018)
Engineered biomaterial and biophysical stimulation as combinatorial strategies to address prosthetic infection by pathogenic bacteria.
Sunil Kumar Boda (2017)
Nanomaterials as Delivery Vehicles and Components of New Strategies to Combat Bacterial Infections: Advantages and Limitations
Atanu Naskar (2019)
Nanoparticles: A promising novel adjunct for dentistry
Jagat Bhushan (2019)
Green synthesis of lignin nano- and micro-particles: Physicochemical characterization, bioactive properties and cytotoxicity assessment.
F. M. C. Freitas (2020)
Gentamicin coated iron oxide nanoparticles as novel antibacterial agents
Proma Bhattacharya (2017)
Antibacterial efficacy of Ocimum sanctum leaf extract-treated iron oxide nanoparticles
Tokeer Ahmad (2017)
The effects of bacteria-nanoparticles interface on the antibacterial activity of green synthesized silver nanoparticles.
A. Ahmad (2017)
The role of reactive oxygen species in the antimicrobial activity of pyochelin
K. S. Ong (2017)
A polyester with hyperbranched architecture as potential nano-grade antibiotics: An in-vitro study.
Srijoni Sengupta (2019)
Nanocomposites: suitable alternatives as antimicrobial agents.
R. Matharu (2018)
Ag and Cu Monometallic and Ag/Cu Bimetallic Nanoparticle-Graphene Composites with Enhanced Antibacterial Performance.
Anna V. Perdikaki (2016)
Visible light inactivation of E. coli, Cytotoxicity and ROS determination of biochemically capped gold nanoparticles.
F. U. Khan (2017)
Functional nanomaterials for the detection and control of bacterial infections.
Huiqiong Jia (2019)See more