Online citations, reference lists, and bibliographies.

Effects Of Dose Reduction On Bone Strength Prediction Using Finite Element Analysis

D. Anitha, Karupppasamy Subburaj, Kai Mei, Felix K. Kopp, Peter Foehr, Peter B. Noel, Jan S. Kirschke, Thomas Baum
Published 2016 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
This study aimed to evaluate the effect of dose reduction, by means of tube exposure reduction, on bone strength prediction from finite-element (FE) analysis. Fresh thoracic mid-vertebrae specimens (n = 11) were imaged, using multi-detector computed tomography (MDCT), at different intensities of X-ray tube exposures (80, 150, 220 and 500 mAs). Bone mineral density (BMD) was estimated from the mid-slice of each specimen from MDCT images. Differences in image quality and geometry of each specimen were measured. FE analysis was performed on all specimens to predict fracture load. Paired t-tests were used to compare the results obtained, using the highest CT dose (500 mAs) as reference. Dose reduction had no significant impact on FE-predicted fracture loads, with significant correlations obtained with reference to 500 mAs, for 80 mAs (R2  = 0.997, p < 0.001), 150 mAs (R2 = 0.998, p < 0.001) and 220 mAs (R2 = 0.987, p < 0.001). There were no significant differences in volume quantification between the different doses examined. CT imaging radiation dose could be reduced substantially to 64% with no impact on strength estimates obtained from FE analysis. Reduced CT dose will enable early diagnosis and advanced monitoring of osteoporosis and associated fracture risk.
This paper references
Pathogenesis and management
J. Pfeilschifter (2000)
10.1088/0952-4746/36/2/346
CT dose reduction: approaches, strategies and results from a province-wide program in Quebec.
Moulay Ali Nassiri (2016)
10.2337/diacare.24.7.1192
Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women.
Kristin K. Nicodemus (2001)
a comparison of hip fracture patients to communitydwelling aged
Magaziner (2003)
effects of bone preservation on MDCT-based trabecular bone microstructure parameters and finite element models
Baum (2015)
The funding agencies had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
10.1016/0378-5122(96)81789-0
Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures.
Dianne Marshall (1996)
10.1111/srt.12001
Gray Hausdorff distance measure for medical image comparison in dermatology: Evaluation of treatment effectiveness by image similarity.
Panagiota Spyridonos (2013)
10.1115/1.1589772
Quantitative computed tomography-based finite element models of the human lumbar vertebral body: effect of element size on stiffness, damage, and fracture strength predictions.
Ruairidh Crawford (2003)
10.1007/s001980050061
How Hip and Whole-Body Bone Mineral Density Predict Hip Fracture in Elderly Women: The EPIDOS Prospective Study
Anne Marie Schott (1998)
10.1016/1350-4533(95)97314-F
Relations of mechanical properties to density and CT numbers in human bone.
Jae Young Rho (1995)
10.3174/ajnr.A0608
Comparison of Low-Dose With Standard-Dose Multidetector CT in Cervical Spine Trauma
T. Mulkens (2007)
10.1148/radiol.2015142859
Informed Consent for Radiation Risk from CT Is Unjustified Based on the Current Scientific Evidence.
H Benjamin Harvey (2015)
10.1016/j.bone.2006.11.017
Discriminative ability of dual-energy X-ray absorptiometry site selection in identifying patients with osteoporotic fractures.
A Arabi (2007)
European Orthopaedic Research Society 24th Annual Meeting
D Anitha (2016)
10.1177/096228029900800204
Measuring agreement in method comparison studies
J Martin Bland (1999)
10.1016/S8756-3282(03)00210-2
Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography.
Ruairidh Crawford (2003)
10.1142/S0219519417500129
THE EFFECT OF COMPUTED TOMOGRAPHY CURRENT REDUCTION ON PROXIMAL FEMUR SUBJECT-SPECIFIC FINITE ELEMENT MODELS
Cristina Falcinelli (2017)
10.3949/ccjm.77a.09091
New tools for detecting occult monoclonal gammopathy, a cause of secondary osteoporosis
Beth M Faiman (2010)
10.1007/s001980170072
An Assessment Tool for Predicting Fracture Risk in Postmenopausal Women
Dennis M Black (2001)
10.1359/jbmr.2000.15.12.2305
Biomechanics of fracture: is bone mineral density sufficient to assess risk?
Barbara R Mccreadie (2000)
10.1200/JCO.2000.18.7.1570
Osteoporosis due to cancer treatment: pathogenesis and management.
J Pfeilschifter (2000)
10.1002/jbm.820281111
Correlations between orthogonal mechanical properties and density of trabecular bone: use of different densitometric measures.
Joyce H. Keyak (1994)
feasibility and accuracy
Higashigaito (2016)
10.1007/s11914-013-0147-2
Advanced CT based In Vivo Methods for the Assessment of Bone Density, Structure, and Strength
Klaus Engelke (2013)
10.1016/S0140-6736(02)08761-5
Diagnosis of osteoporosis and assessment of fracture risk
John A. Kanis (2002)
10.1148/radiol.2472070982
Proximal femur specimens: automated 3D trabecular bone mineral density analysis at multidetector CT--correlation with biomechanical strength measurement.
Markus B. Huber (2008)
10.1007/s11914-013-0174-z
Effects of Radiation on Bone
Rafael Araújo Pacheco (2013)
10.1186/s12880-015-0066-z
Osteoporosis imaging: effects of bone preservation on MDCT-based trabecular bone microstructure parameters and finite element models
Thomas Baum (2015)
Mortality and osteoporotic fractures: is the link causal, and is it modifiable?
G G Teng (2008)
10.1016/0021-9290(94)90056-6
Predicting the compressive mechanical behavior of bone.
Tony S. Keller (1994)
an alternative to conventional radiography
Horger (2005)
10.1007/s00198-013-2544-x
A low-radiation exposure protocol for 3D QCT of the spine
O. Museyko (2013)
10.5493/wjem.v5.i3.182
Computed tomography-based finite element analysis to assess fracture risk and osteoporosis treatment.
Kazuhiro Imai (2015)
10.1002/jbmr.2069
Assessment of incident spine and hip fractures in women and men using finite element analysis of CT scans.
David L. Kopperdahl (2014)
10.1007/s00198-013-2424-4
Implications of local osteoporosis on the efficacy of anti-resorptive drug treatment: a 3-year follow-up finite element study in risedronate-treated women
Dr. R. Anitha (2013)
10.1359/jbmr.070728
Structural determinants of vertebral fracture risk.
L. Joseph Iii Melton (2007)
10.1007/s40279-013-0100-7
Bone Quality: The Determinants of Bone Strength and Fragility
H Fonseca (2013)
10.1016/j.ejrad.2004.04.015
Whole-body low-dose multidetector row-CT in the diagnosis of multiple myeloma: an alternative to conventional radiography.
Marius Stefan Horger (2005)
10.1093/aje/kwg081
Changes in functional status attributable to hip fracture: a comparison of hip fracture patients to community-dwelling aged.
Jay S. Magaziner (2003)
10.1016/S8756-3282(99)00098-8
The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone.
Dolph Ulrich (1999)
10.2307/2532051
A concordance correlation coefficient to evaluate reproducibility.
Lawrence I-Kuei Lin (1989)
10.1148/radiol.2442060606
Multidetector CT in patients suspected of having lumbar disk herniation: comparison of standard-dose and simulated low-dose techniques.
Pascale Bohy (2007)
www.nature.com
use of different densitometric measures
J. H. Keyak (1994)
10.1016/S1350-4533(01)00045-5
Improved prediction of proximal femoral fracture load using nonlinear finite element models.
Joyce H. Keyak (2001)
10.1016/S0021-9290(99)00099-8
Femoral strength is better predicted by finite element models than QCT and DXA.
Dianna D. Cody (1999)
Acknowledgements This work was supported by the following research grants: Deutsche Forschungsgemeinschaft (DFG) BA 4085/2–1 (JSK) and BA 4906
10.1016/0021-9290(94)90014-0
The relationship between the structural and orthogonal compressive properties of trabecular bone.
Rick Goulet (1994)
10.1016/S1350-4533(03)00081-X
Comparison of in situ and in vitro CT scan-based finite element model predictions of proximal femoral fracture load.
Joyce H. Keyak (2003)
10.1148/radiographics.14.1.8128043
Skeletal complications of radiation therapy.
David A. Bluemke (1994)
Scientific RepoRts |
The EPIDOS prospective study
Schott (1998)
10.1093/oxfordjournals.aje.a115204
Epidemiology of vertebral fractures in women.
L. Joseph Iii Melton (1989)
10.1016/j.crad.2016.04.023
Automatic radiation dose monitoring for CT of trauma patients with different protocols: feasibility and accuracy.
Kai Higashigaito (2016)



This paper is referenced by
10.3389/fendo.2020.00442
Finite Element Analysis-Based Vertebral Bone Strength Prediction Using MDCT Data: How Low Can We Go?
Nithin Manohar Rayudu (2020)
10.1007/s11914-018-0438-8
Are CT-Based Finite Element Model Predictions of Femoral Bone Strengthening Clinically Useful?
Marco Viceconti (2018)
10.1007/s00062-018-0722-0
MDCT-based Finite Element Analysis of Vertebral Fracture Risk: What Dose is Needed?
Dr. R. Anitha (2018)
10.1038/s41598-018-33444-5
Bone mineral density assessment using iterative reconstruction compared with quantitative computed tomography as the standard of reference
Constanze Mann (2018)
10.1007/s00198-017-4342-3
Feasibility of opportunistic osteoporosis screening in routine contrast-enhanced multi detector computed tomography (MDCT) using texture analysis
Muthu Rama Krishnan Mookiah (2017)
10.1038/s41598-019-43028-6
Neuro-musculoskeletal flexible multibody simulation yields a framework for efficient bone failure risk assessment
Andreas Geier (2019)
10.1016/j.spinee.2019.11.015
Effect of the intervertebral disc on vertebral bone strength prediction: a Finite-Element Study.
D. Anitha (2019)
10.1007/s00198-019-05212-2
X-ray-based quantitative osteoporosis imaging at the spine
M.T. Löffler (2019)
10.1097/RCT.0000000000000788
Effect of Statistically Iterative Image Reconstruction on Vertebral Bone Strength Prediction Using Bone Mineral Density and Finite Element Modeling: A Preliminary Study
Dr.V.R. Anitha (2019)
10.1007/s00774-017-0836-5
Effect of radiation dose reduction on texture measures of trabecular bone microstructure: an in vitro study
Muthu Rama Krishnan Mookiah (2017)
10.1007/s11657-020-0708-9
Low-dose and sparse sampling MDCT-based femoral bone strength prediction using finite element analysis
Nithin Manohar Rayudu (2020)
10.1097/RCT.0000000000000710
Multidetector Computed Tomography Imaging: Effect of Sparse Sampling and Iterative Reconstruction on Trabecular Bone Microstructure
Muthu Rama Krishnan Mookiah (2018)
Semantic Scholar Logo Some data provided by SemanticScholar