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Mechanism Of Cell Death Induced By Magnetic Hyperthermia With Nanoparticles Of γ-MnxFe2–xO3 Synthesized By A Single Step Process
N. K. Prasad, K. Rathinasamy, D. Panda, D. Bahadur
Published 2007 · Chemistry
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Magnetic nanoparticles of γ-MnxFe2–xO3 (0 ≤ x ≤ 1.3) have been synthesized successfully using a single step process wherein the respective inorganic salts were thermally decomposed in ethylene glycol at 200 °C. Single phase formation is evident in the as prepared dried samples without any further treatment. XRD line broadening along with TEM suggest that the particle size is below 30 nm. Both the magnetic and XRD data support the substitution of Mn3+ ions at the tetrahedral site of γ-Fe2O3. Improved magnetization value (78 emu g–1) is obtained for the sample with x = 0.2 compared to one with x = 0 (62 emu g–1) if measured at 20 kOe. Aqueous suspensions of the sample with x = 0.2 were prepared using a polymer, Acrypol 934, with an aim to examine the possible use of these suspensions in the magnetic hyperthermia treatment of cancer. These suspensions were found to be biocompatible at concentration as high as 3.75 mg mL–1 of culture media. Hyperthermia induced by the application of an AC magnetic field in the presence of the above suspension caused HeLa cell death. The cell death was found to be proportional to the quantity of the particles and the duration of application of the AC magnetic field. Following hyperthermia treatment, cells showed varying degrees of membrane blebbing with significant disruption of the actin and tubulin cytoskeletons. The apparent disruption of the actin and microtubule cytoskeletons of cells might be responsible for the death of cells following hyperthermia treatment. These observations suggest that the suspension of these particles may be evaluated for magnetic hyperthermia treatment of cancer.
This paper references
Magnetic properties of capped, soluble MnFe2O4 nanoparticles
Ombretta Masala (2005)
Advanced Inorganic Chemistry
F. Cotton (1999)
New Technique for Synthesizing Iron Ferrite Magnetic Nanosized Particles
N. Feltin (1997)
Integrin and cytoskeleton behaviour in human neuroblastoma cells during hyperthermia-related apoptosis
F. Luchetti (2004)
Cytochemical Methods for the Detection of Apoptosis
M. Willingham (1999)
Ultrasensitive magnetic biosensor for homogeneous immunoassay.
Y. Chemla (2000)
Biocompatible suspension of nanosized γ‐Fe2O3 synthesized by novel methods
N. K. Prasad (2005)
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.
N. Nasongkla (2006)
Preparation and investigation of potentiality of different soft ferrites for hyperthermia applications
J. Giri (2005)
Crystallite Size Variations of Nanosized Fe2O3Powders during γ- to α-Phase Transformation
F. Yen (2002)
Fine structure and magnetic properties of Mn‐ and Co‐doped nanocrystalline γ‐Fe2O3
Ming‐Cheng Deng (1994)
Structure of α-Mn2O3, (Mn0.983Fe0.017)2O3 and (Mn0.37Fe0.63)2O3 and relation to magnetic ordering
S. Geller (1971)
Mixed Iron−Manganese Oxide Nanoparticles
J. Lai (2004)
Electrochemical Synthesis for the Control of γ-Fe2O3 Nanoparticle Size. Morphology, Microstructure, and Magnetic Behavior
Cécile Pascal (1999)
Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin.
Kamlesh Gupta (2004)
Intracellular hyperthermia. A biophysical approach to cancer treatment via intracellular temperature and biophysical alterations.
R. Gordon (1979)
Development of Ni-4 wt.% Si thermoseeds for hyperthermia cancer treatment.
J. Chen (1988)
Kinetic suppression of microtubule dynamic instability by griseofulvin: implications for its possible use in the treatment of cancer.
D. Panda (2005)
Is intracellular hyperthermia superior to extracellular hyperthermia in the thermal sense?
Y. Rabin (2002)
Heating potential of iron oxides for therapeutic purposes in interventional radiology.
I. Hilger (2002)
Evaluation of the CoCrTaPt alloy for longitudinal magnetic recording
Yuanda Cheng (1994)
Magnetic fluid hyperthermia (MFH)reduces prostate cancer growth in the orthotopic Dunning R3327 rat model
M. Johannsen (2005)
Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro
A. Jordan (1999)
Epithelial internalization of superparamagnetic nanoparticles and response to external magnetic field
D. Kenneth (2005)
Solid Oxides and Hydroxides of Manganese1
T. E. Moore (1950)
B. Calhoun (1955)
Towards breast cancer treatment by magnetic heating
I. Hilger (2005)
A Novel Route to Toluene-Soluble Magnetic Oxide Nanoparticles: Aqueous Hydrolysis Followed by Surfactant Exchange
M. Ghosh (2004)
Inhibition of protein synthesis sensitizes thermotolerant cells to heat shock induced apoptosis
B. Poe (2004)
Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration.
Keith M. Erikson (2005)
Surface and complexation effects on the rate of Mn(II) oxidation in natural waters
D. Wilson (1980)
Introduction to Magnetic Materials
B. Cullity (1972)
Ferromagnetic hyperthermia: functional and histopathologic effects on normal rabbit ocular tissue.
T. Murray (1997)
Use of magnetic techniques for the isolation of cells.
I. Šafařík (1999)
The cellular and molecular basis of hyperthermia.
B. Hildebrandt (2002)
Magnetic nanoparticle design for medical diagnosis and therapy
S. Mornet (2004)
Maghemite nanoparticles with very high AC-losses for application in RF-magnetic hyperthermia
R. Hergt (2004)
A direct correlation between hyperthermia‐induced membrane blebbing and survival in synchronous G1 CHO cells
M. Borrelli (1986)
Numerical simulation of the thermal fields occurring in the treatment of malignant tumors by local hyperthermia.
K. O’brien (1993)
Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia.
Jean-Paul Fortin (2007)
Oxidative removal of Mn(II) from solution catalysed by the γ-FeOOH (lepidocrocite) surface
W. Sung (1981)
Optimization of parameters for the synthesis of nano-sized Co1−xZnxFe2O4, (0 ≤ x ≤ 0.8) by microwave refluxing
J. Giri (2004)
Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo.
A. Jordan (1997)
Preparation of cellulose-based biocompatible suspension of nano-sized /spl gamma/-Al/sub x/Fe/sub 2-x/O/sub 3/
N. K. Prasad (2005)
Controlled growth of monodisperse silica spheres in the micron size range
W. Stoeber (1968)
Biomedical applications of maghemite ferrofluid.
A. Halbreich (1998)
Magnetic and Crystallographic Transitions in the α-Mn 2 O 3 - Fe 2 O 3 System
R. Grant (1968)
A high-sensitivity micromachined biosensor
D. R. Baselt (1997)
Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme
K. Maier-Hauff (2006)
Characterization of Nanocrystalline γ–Fe 2 O 3 Prepared by Wet Chemical Method
G. Ennas (1999)
Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles
A. Jordan (1999)
Electromagnetic heating of breast tumors in interventional radiology: in vitro and in vivo studies in human cadavers and mice.
I. Hilger (2001)
Shape-controlled synthesis and shape-induced texture of MnFe2O4 nanoparticles.
H. Zeng (2004)
Identification of apoptotic and necrotic human leukemic cells by flow cytometry.
L. Huschtscha (1994)
Actin cleavage by CPP-32/apopain during the development of apoptosis
T. Mashima (1997)
Doping gamma-Fe(2)O(3) nanoparticles with Mn(III) suppresses the transition to the alpha-Fe(2)O(3) structure.
J. Lai (2003)
The heating effect of magnetic fluids in an alternating magnetic field
Xuman Wang (2005)
TOPICAL REVIEW: Functionalisation of magnetic nanoparticles for applications in biomedicine
C. Berry (2003)
Enhancement of AC-losses of magnetic nanoparticles for heating applications
R. Hergt (2004)
Possible health effects of high manganese concentration in drinking water.
X. Kondakis (1989)
This paper is referenced by
Magnetic Solid-State Materials
R. S. Joshi (2013)
Surface engineering of iron oxide nanoparticles for cancer therapy
Santosh L. Gawali (2017)
Bio‐Sensing Performance of Magnetite Nanocomposite for Biomedical Applications
Rajasekhar Chokkareddy (2018)
Magnetic nanofibers based bandage for skin cancer treatment: a non-invasive hyperthermia therapy.
Kaushik Suneet (2020)
AC magnetic field regulated in-vivo switch of Hf-substituted magnetite (Hf x Fe 3-x O 4 , 0.01 ≤x ≤ 0.8) nanoparticles
M. Srivastava (2016)
Thermal, structural analysis, Mossbauer and impedance study of copper nickel ferrite nanoparticles synthesized via Tween 80-assisted hydrothermal process
Shahid Khan (2015)
Synthesis of aligned hematite nanoparticles on chitosan-alginate films.
K. Sreeram (2009)
Alternating Magnetic Field Controlled, Multifunctional Nano-Reservoirs: Intracellular Uptake and Improved Biocompatibility
Santaneel Ghosh (2009)
Applications of magnetic nanoparticles in medicine: magnetic fluid hyperthermia.
M. Latorre (2009)
Cytotoxic effect of thermosensitive magnetoliposomes loaded with gemcitabine and paclitaxel on human primary breast cancer cells (MGSO-3 line)
R. F. L. Ribeiro (2020)
Magnetocuring of temperature failsafe epoxy adhesives
Richa Chaudhary (2020)
Porous magnetite secondary particles prepared by surfactant-free solvothermal method with non-contact heat-assisted drug releasing property
S. Kim (2016)
Manganite Pervoskite Nanoparticles: Synthesis, Heating Mechanism, Toxicity, and Self-regulated Hyperthermia
Navadeep Shrivastava (2020)
Oxide and hybrid nanostructures for therapeutic applications.
S. Chandra (2011)
Nanoparticle-mediated magnetic hyperthermia is an effective method for killing the human-infective protozoan parasite Leishmania mexicana in vitro
Sarah L. Berry (2019)
Magnetic hyperthermia with magnetic nanoparticles: a status review.
A. B. Salunkhe (2014)
Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool
J. Jose (2019)
Magnetic nanoparticle-induced hyperthermia treatment under magnetic resonance imaging.
A. A. Elsherbini (2011)
Magnetic hyperthermia with biphasic gel of La1−xSrxMnO3 and maghemite
N. Prasad (2009)
Multifunctional carboxymethyl cellulose-based magnetic nanovector as a theragnostic system for folate receptor targeted chemotherapy, imaging, and hyperthermia against cancer.
B. Sivakumar (2013)
Fungal Nanotechnology: A New Approach Toward Efficient Biotechnology Application
C. Romero (2018)
Biocompatible phosphate anchored Fe3O4 nanocarriers for drug delivery and hyperthermia
P. Sharma (2014)
Role of engineered nanocarriers for axon regeneration and guidance: current status and future trends.
Somesree Ghoshmitra (2012)
Flow of magnetic particles in blood with isothermal heating: A fractional model for two-phase flow
F. Ali (2018)
Magnetic nanoparticle-based cancer therapy
Y. Jing (2013)
Potential use of SERS-assisted theranostic strategy based on Fe3O4/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia.
Y. Han (2016)
Black phosphorus: A novel nanoplatform with potential in the field of bio-photonic nanomedicine
Taojian Fan (2018)
In vitro evaluation of PEGylated mesoporous MgFe2O4 magnetic nanoassemblies (MMNs) for chemo-thermal therapy.
S. Kumar (2013)
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery.
Challa S. S. R. Kumar (2011)
Applications of nanomaterials inside cells
J. Gao (2009)
Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia
S. Balasubramanian (2014)
In-vitro Application of Doxorubicin Loaded Magnetoplasmonic Thermosensitive Liposomes for Laser Hyperthermia and Chemotherapy of Breast Cancer
M. Khosroshahi (2015)See more