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A Facile Synthesis Of Sialylated Oligolactosamine Glycans From Lactose Via The Lafont Intermediate

Peng Peng, Han Liu, Jianzhi Gong, John M. Nicholls, Xuechen Li

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We have developed a facile synthesis of sialylated oligolactosamine glycans, including Neu5Ac-α-2,3LacNAc-β-1,3LacNAc (3′SLN-LN) and Neu5Ac-α-2,3LacNAc-β-1,3LacNAc-β-1,3LacNAc (3′SLN-LN-LN), also providing a useful method for the preparation of 2-amino sugar building blocks.