Online citations, reference lists, and bibliographies.
← Back to Search

Multi-modal MR Imaging And Magnetic Hyperthermia Study Of Gd Doped Fe3O4 Nanoparticles For Integrative Cancer Therapy

N. Thorat, R. Bohara, H. Yadav, S. Tofail
Published 2016 · Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
Among different kinds of cancer theranostic mediators, gadolinium (Gd) doped iron oxide nanoparticles are one of the most promising candidates in combining diagnostics (imaging) and therapeutics (molecular therapy) functions in a single, multimodal platform. Due to its larger size, the doping of Gd into the Fe3O4 is difficult. We have overcome this difficulty by modifying a polyol based reflux method that has been previously used for, for example, cobalt–zinc (Co–Zn) doping of ferrites but not for doping with Gd. This modified approach allowed a facile synthesis of Gd-doped superparamagnetic iron oxide (Fe3O4) nanoparticles (GdSPIONPs) with a lower Curie temperature (Tc) for hyperthermia superparamagnetism with low coercivity, both T1 and T2 based MRI contrast enhancements, low cytotoxicity and optimal hemocompatibility. Such a combination of theranostics properties in a single nanosystem is unprecedented and highly desirable for heat controlled magnetic hyperthermia in minimizing treatment resistance, and maximizing treatment efficacy.
This paper references
10.1016/J.JMMM.2014.10.082
Influence of cobalt doping on the hyperthermic efficiency of magnetite nanoparticles
E. Fantechi (2015)
10.1039/c5nr07849k
Porphyrin-loaded nanoparticles for cancer theranostics.
Y. Zhou (2016)
10.1021/nl0805615
Method for analysis of nanoparticle hemolytic properties in vitro.
M. Dobrovolskaia (2008)
10.1063/1.4919327
Alternating current magnetic susceptibility and heat dissipation by Mn1−xZnxFe2O4 nanoparticles for hyperthermia treatment
T. Kondo (2015)
10.1021/ACS.JPCC.5B02555
A Single Picture Explains Diversity of Hyperthermia Response of Magnetic Nanoparticles
Iván Conde-Leborán (2015)
10.1021/acsami.6b02616
Multimodal Superparamagnetic Nanoparticles with Unusually Enhanced Specific Absorption Rate for Synergetic Cancer Therapeutics and Magnetic Resonance Imaging.
N. Thorat (2016)
10.1039/c5dt03736k
Magnetic nanoscale metal organic frameworks for potential targeted anticancer drug delivery, imaging and as an MRI contrast agent.
Angshuman Ray Chowdhuri (2016)
10.1039/c4dt00162a
Reducing the inversion degree of MnFe2O4 nanoparticles through synthesis to enhance magnetization: evaluation of their (1)H NMR relaxation and heating efficiency.
K. Vamvakidis (2014)
10.7150/thno.5366
Superparamagnetic Iron Oxide Nanoparticles as MRI contrast agents for Non-invasive Stem Cell Labeling and Tracking
L. Li (2013)
10.1016/J.APSUSC.2013.09.169
Magnetic chitosan nanocomposite for hyperthermia therapy application: Preparation, characterization and in vitro experiments
P. B. Shete (2014)
10.1039/c5cp00831j
Nanosystems: the use of nanoalloys, metallic, bimetallic, and magnetic nanoparticles in biomedical applications.
K. McNamara (2015)
10.1039/c5cs00541h
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles.
H. Arami (2015)
10.1016/S0005-2736(99)00125-X
Gadolinium induces domain and pore formation of human erythrocyte membrane: an atomic force microscopic study.
Y. Cheng (1999)
10.1063/1.1846271
Mössbauer spectroscopy investigation of Mn-substituted Co-ferrite (CoMnxFe2−xO4)
K. Krieble (2004)
10.1088/0031-8949/84/04/045702
Effect of Gd3+ doping on the structural and magnetic properties of nanocrystalline Ni?Cd mixed ferrite
Binu P. Jacob (2011)
10.1016/j.colsurfb.2015.12.012
Preparation, characterization and in vivo investigation of blood-compatible hemoglobin-loaded nanoparticles as oxygen carriers.
M. Lu (2016)
10.1166/JNN.2011.3184
Preferential site of Gd in Gd-doped Fe3O4 nanopowder.
Y. Kim (2011)
10.1021/nn2021088
Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell "vision" versus physicochemical properties of nanoparticles.
M. Mahmoudi (2011)
10.1039/c2dt32508j
Bi-functional properties of Fe3O4@YPO4:Eu hybrid nanoparticles: hyperthermia application.
A. Prasad (2013)
10.1016/j.msec.2015.10.064
In vitro hyperthermia with improved colloidal stability and enhanced SAR of magnetic core/shell nanostructures.
R. Patil (2016)
10.1039/C3RA44644A
Non-aqueous to aqueous phase transfer of oleic acid coated iron oxide nanoparticles for hyperthermia application
R. M. Patil (2014)
10.7150/thno.11544
Magnetic Nanoparticles in Cancer Theranostics
O. Gobbo (2015)
10.2217/nnm.15.148
Bioapplications of boron nitride nanotubes.
G. Genchi (2015)
10.1002/ADFM.201502868
Gadolinium‐Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System
G. Zhang (2015)
10.1039/C5RA04553C
Cancer cell extinction through a magnetic fluid hyperthermia treatment produced by superparamagnetic Co–Zn ferrite nanoparticles
R. Bohara (2015)
10.1021/acsami.5b00727
pH-responsive iron manganese silicate nanoparticles as T1-T2* dual-modal imaging probes for tumor diagnosis.
J. Chen (2015)
10.1039/c5cp04539h
The role of size polydispersity in magnetic fluid hyperthermia: average vs. local infra/over-heating effects.
Cristina Munoz-Menendez (2015)
10.1039/c5cp02822a
Mechanisms of AC losses in magnetic fluids based on substituted manganites.
V. Kalita (2015)
10.1021/ACS.JPCC.5B06037
Synthesis of Water-Dispersible Gd2O3/GO Nanocomposites with Enhanced MRI T1 Relaxivity
F. Wang (2015)
10.1016/J.JMMM.2005.02.023
Synthesis and investigation of magnetic properties of Gd-substituted Mn–Zn ferrite nanoparticles as a potential low-TC agent for magnetic fluid hyperthermia
T. Brusentsova (2005)
10.2217/nnm.14.236
Targeted nanoscale magnetic hyperthermia: challenges and potentials of peptide-based targeting.
D. Fourmy (2015)
10.1088/0022-3727/48/49/494001
Thermosensitive polymer-grafted iron oxide nanoparticles studied by in situ dynamic light backscattering under magnetic hyperthermia
G. Hemery (2015)
10.1063/1.4819809
Role of inhomogeneous cation distribution in magnetic enhancement of nanosized Ni0.35Zn0.65Fe2O4: A structural, magnetic, and hyperfine study
S. Dey (2013)
10.1016/j.jcis.2013.11.020
T1-T2 dual-modal MRI of brain gliomas using PEGylated Gd-doped iron oxide nanoparticles.
N. Xiao (2014)
10.1039/c5cc00285k
A multiple gadolinium complex decorated fullerene as a highly sensitive T(1) contrast agent.
Lirong Wang (2015)
10.1063/1.4868709
Controlling temperature in magnetic hyperthermia with low Curie temperature particles
I. Aştefănoaei (2014)
10.1039/c4dt03013c
Synthesis methods to prepare single- and multi-core iron oxide nanoparticles for biomedical applications.
L. Gutiérrez (2015)
10.1002/EJIC.201600706
Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature – Cancer Theranostics for MR‐Imaging‐Guided Magneto‐Chemotherapy
N. Thorat (2016)
10.1016/J.MATTOD.2015.08.022
Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances.
R. Revia (2016)
10.1021/acsnano.5b01288
IGF1 Receptor Targeted Theranostic Nanoparticles for Targeted and Image-Guided Therapy of Pancreatic Cancer.
H. Zhou (2015)
10.1016/j.msec.2015.10.079
Copper/zinc bimetal nanoparticles-dispersed carbon nanofibers: A novel potential antibiotic material.
M. Ashfaq (2016)
10.1186/1556-276X-6-554
Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics
Dana E. Gheorghe (2011)
10.1039/c4dt02293a
Synthesis, characterization and biocompatibility of chitosan functionalized superparamagnetic nanoparticles for heat activated curing of cancer cells.
N. Thorat (2014)
10.1039/c2dt11835a
Polyvinyl alcohol: an efficient fuel for synthesis of superparamagnetic LSMO nanoparticles for biomedical application.
N. Thorat (2012)
10.1088/0957-4484/27/11/115101
In vitro study on apoptotic cell death by effective magnetic hyperthermia with chitosan-coated MnFe₂O₄.
Yunok Oh (2016)
10.1021/acsnano.5b05783
Parallel Comparative Studies on Mouse Toxicity of Oxide Nanoparticle- and Gadolinium-Based T1 MRI Contrast Agents.
R. Chen (2015)
10.2147/IJN.S68719
Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
Shih-Hsiang Liao (2015)
10.1088/0957-4484/26/36/365102
Dual-mode T1 and T2 magnetic resonance imaging contrast agent based on ultrasmall mixed gadolinium-dysprosium oxide nanoparticles: synthesis, characterization, and in vivo application.
Tirusew Tegafaw (2015)
10.1177/0885328209351136
Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl2-NaNO3-NaOH Aqueous System
Zhixia Li (2011)



This paper is referenced by
10.1016/j.carbpol.2020.117262
A biocompatible theranostic nanoplatform based on magnetic gadolinium-chelated polycyclodextrin: in vitro and in vivo studies
Hedieh Mansouri (2020)
10.1016/J.JMMM.2018.02.029
Probing influence of rare earth ions (Er 3+ , Dy 3+ and Gd 3+ ) on structural, magnetic and optical properties of magnetite nanoparticles
R. Jain (2018)
10.2147/IJN.S179273
Drug delivery to atherosclerotic plaques using superparamagnetic iron oxide nanoparticles
Jasmin Matuszak (2018)
10.1016/j.eurpolymj.2020.109638
Magnetic particle anchored reduction and pH responsive nanogel for enhanced intracellular drug delivery
P. Mandal (2020)
10.1515/ntrev-2017-0193
NiCu magnetic nanoparticles: review of synthesis methods, surface functionalization approaches, and biomedical applications
I. Ban (2018)
10.1088/1361-6528/ab912e
Synthesis of Fe3O4@Gd2O3:Tb3+@SiOx multifunctional nanoparticles and their luminescent, magnetic and hyperthermia properties.
R. Fu (2020)
10.3390/s20072151
Specific Loss Power of Co/Li/Zn-Mixed Ferrite Powders for Magnetic Hyperthermia
G. Barrera (2020)
10.1063/1.5049467
Physically stimulated nanotheranostics for next generation cancer therapy: Focus on magnetic and light stimulations
N. Thorat (2019)
10.1002/ADFM.201606821
Morphological Evolution and Magnetic Property of Rare‐Earth‐Doped Hematite Nanoparticles: Promising Contrast Agents for T1‐Weighted Magnetic Resonance Imaging
H. Wan (2017)
10.1039/C7RA07460C
Core@shell Fe3O4@Mn2+-doped NaYF4:Yb/Tm nanoparticles for triple-modality T1/T2-weighted MRI and NIR-to-NIR upconversion luminescence imaging agents
Y. Luo (2017)
10.3938/JKPS.73.112
Magnetic Properties and Mössbauer Studies of Fe3O4 Substituted with Gd Ions
Jeongho Park (2018)
10.1016/j.bbrep.2017.12.002
Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles
R. Patil (2018)
Gd 3 +-Doped Magnetic Nanoparticles for Biomedical Applications
A. Budnyk (2018)
10.1039/d0ra01807d
An ultra-sensitive T2-weighted MR contrast agent based on Gd3+ ion chelated Fe3O4 nanoparticles
J. Chen (2020)
10.1002/adtp.202000061
Magnetic Fluid Hyperthermia Based on Magnetic Nanoparticles: Physical Characteristics, Historical Perspective, Clinical Trials, Technological Challenges, and Recent Advances
H. Etemadi (2020)
10.1155/2018/1412563
Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications
A. Budnyk (2018)
10.1038/s41598-020-58605-3
Effects of multiple injections on the efficacy and cytotoxicity of folate-targeted magnetite nanoparticles as theranostic agents for MRI detection and magnetic hyperthermia therapy of tumor cells
M. Soleymani (2020)
10.3390/ma13184147
Impact of Gadolinium on the Structure and Magnetic Properties of Nanocrystalline Powders of Iron Oxides Produced by the Extraction-Pyrolytic Method
V. Serga (2020)
10.1016/j.colsurfb.2019.110531
Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field.
Tefera Worku Mekonnen (2019)
10.1039/c7nr03684a
Survival of Verwey transition in gadolinium-doped ultrasmall magnetite nanoparticles.
S. Yeo (2017)
10.1016/B978-0-08-101925-2.00007-3
Current Outlook and Perspectives on Nanoparticle-Mediated Magnetic Hyperthermia
C. Blanco-Andujar (2018)
Semantic Scholar Logo Some data provided by SemanticScholar