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Multi-modal MR Imaging And Magnetic Hyperthermia Study Of Gd Doped Fe3O4 Nanoparticles For Integrative Cancer Therapy
N. Thorat, R. Bohara, H. Yadav, S. Tofail
Published 2016 · Materials Science
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Among different kinds of cancer theranostic mediators, gadolinium (Gd) doped iron oxide nanoparticles are one of the most promising candidates in combining diagnostics (imaging) and therapeutics (molecular therapy) functions in a single, multimodal platform. Due to its larger size, the doping of Gd into the Fe3O4 is difficult. We have overcome this difficulty by modifying a polyol based reflux method that has been previously used for, for example, cobalt–zinc (Co–Zn) doping of ferrites but not for doping with Gd. This modified approach allowed a facile synthesis of Gd-doped superparamagnetic iron oxide (Fe3O4) nanoparticles (GdSPIONPs) with a lower Curie temperature (Tc) for hyperthermia superparamagnetism with low coercivity, both T1 and T2 based MRI contrast enhancements, low cytotoxicity and optimal hemocompatibility. Such a combination of theranostics properties in a single nanosystem is unprecedented and highly desirable for heat controlled magnetic hyperthermia in minimizing treatment resistance, and maximizing treatment efficacy.
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