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Selective Growth Inhibition Of Cancer Cells With Doxorubicin-loaded CB[7]-modified Iron-oxide Nanoparticles

F. Benyettou, H. Fahs, R. El-kharrag, R. Bilbeisi, B. Asma, Rachid Rezgui, L. Motte, Mazin Magzoub, Jérémy Brandel, J. Olsen, F. Piano, F. Piano, K. Gunsalus, K. Gunsalus, C. Platas-Iglesias, A. Trabolsi
Published 2017 · Chemistry

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Cucurbit[7]uril-modified iron-oxide nanoparticles (CB[7]NPs) were loaded with doxorubicin hydrochloride (Dox) and tested as a drug delivery system. Dox was found to interact with the carbonyl-rich rims of the CB[7] macrocycles adsorbed on the surface of the nanoparticles. The Dox-loaded nanoparticles (Dox@CB[7]NPs) were stable at room temperature and physiological pH and released their Dox cargo under acidic conditions, in the presence of glutathione, or with heating. Dox@CB[7]NPs reduced the viability of HeLa and three other cancer-derived cell lines in vitro at lower IC50 than free Dox. They were also nontoxic to C. elegans. The sensitivity of HeLa cells to Dox@CB[7]NPs was enhanced when the temperature was elevated by application of an alternating magnetic field. Thus, Dox@CB[7]NPs show promise as agents for the intracellular delivery of Dox to cancer cells, for the selective and controlled release of the drug, and, more generally, as a possible means of combining chemotherapeutic and hyperthermic treatment modalities.
This paper references
10.1097/01.gco.0000192996.20040.24
Side-effects of chemotherapy and quality of life in ovarian and breast cancer patients
A. E. Kayl (2006)
10.1039/c2cc30679d
Live-cell monitoring of the glutathione-triggered release of the anticancer drug topotecan on gold nanoparticles in serum-containing media.
M. Kim (2012)
10.2147/IJN.S84909
Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage
M. Charão (2015)
10.1158/1078-0432.CCR-1004-0016
Application of High Amplitude Alternating Magnetic Fields for Heat Induction of Nanoparticles Localized in Cancer
R. Ivkov (2005)
10.1016/j.biomaterials.2010.11.028
Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy.
Murali M Yallapu (2011)
10.1016/j.cis.2011.04.003
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles.
S. Laurent (2011)
10.1021/CM3036746
Colloidal Ordered Assemblies in a Polymer Shell—A Novel Type of Magnetic Nanobeads for Theranostic Applications
N. C. Bigall (2013)
10.1039/C3TB20852D
Toward theranostic nanoparticles: CB[7]-functionalized iron oxide for drug delivery and MRI.
F. Benyettou (2013)
10.1016/j.bbamcr.2012.06.019
Glutathione and modulation of cell apoptosis.
Magdalena L. Circu (2012)
10.1038/nmat3776
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
10.1021/am4004705
Ultrasound, pH, and magnetically responsive crown-ether-coated core/shell nanoparticles as drug encapsulation and release systems.
Siu-Fung Lee (2013)
10.2165/00003088-200342050-00002
Pharmacokinetics of Pegylated Liposomal Doxorubicin
A. Gabizon (2003)
10.1371/journal.pone.0006622
In Caenorhabditis elegans Nanoparticle-Bio-Interactions Become Transparent: Silica-Nanoparticles Induce Reproductive Senescence
Adam Pluskota (2009)
10.1021/JA0319846
Mechanism of host-guest complexation by cucurbituril.
César Marquez (2004)
10.1016/S0304-8853(10)80013-7
Biological systems in high magnetic field
A. Yamagishi (1990)
10.1016/J.JMMM.2008.12.017
Size-dependant heating rates of iron oxide nanoparticles for magnetic fluid hyperthermia.
M. Gonzales-Weimuller (2009)
10.1039/B618596G
Magnetite ferrofluids stabilized by sulfonato-calixarenes.
S. Chin (2007)
10.1080/02656730110108785
Magnetically mediated hyperthermia: current status and future directions
P. Moroz (2002)
10.1039/B505641C
A previously unrecognised hydronium di-cation in the crystal structure of a cucurbituril derivative.
I. Bernal (2005)
10.1016/j.biomaterials.2013.06.046
Cancer therapy and fluorescence imaging using the active release of doxorubicin from MSPs/Ni-LDH folate targeting nanoparticles.
Dian Li (2013)
10.1021/cm503304p
Mesoporous Silica Nanoparticles Coated by Layer-by-Layer Self-assembly Using Cucurbit[7]uril for in Vitro and in Vivo Anticancer Drug Release
Qing-Lan Li (2014)
10.1021/nn403443r
Effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans.
Andrea Scharf (2013)
10.1088/0957-4484/22/5/055102
Microwave assisted nanoparticle surface functionalization.
F. Benyettou (2011)
Acid pH in tumors and its potential for therapeutic exploitation.
I. Tannock (1989)
Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.
L. Gerweck (1996)
10.1021/ja1022267
Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles.
Courtney R. Thomas (2010)
10.1016/J.TCA.2005.01.002
Complexation behavior of cucurbit[6]uril with short polypeptides
H. Buschmann (2005)
10.1038/bjc.1996.228
Inhibition of angiogenesis and murine tumour growth by laminarin sulphate.
R. Hoffman (1996)
10.1039/c3nr03905f
Microworms swallow the nanobait: the use of nanocoated microbial cells for the direct delivery of nanoparticles into Caenorhabditis elegans.
Gölnur I. Däwlätşina (2013)
10.1021/nn500962q
Nanoparticles for Imaging, Sensing, and Therapeutic Intervention
L. Bogart (2014)
10.1002/chem.201602956
Mesoporous γ-Iron Oxide Nanoparticles for Magnetically Triggered Release of Doxorubicin and Hyperthermia Treatment.
F. Benyettou (2016)
10.1021/nl2001499
Triggered release from liposomes through magnetic actuation of iron oxide nanoparticle containing membranes.
E. Amstad (2011)
10.1016/j.chemosphere.2009.04.067
A fluorescence quenching study of the interaction of Suwannee River fulvic acid with iron oxide nanoparticles.
A. Manciulea (2009)
10.1039/C5TC00369E
One-pot solvothermal synthesis of biocompatible magnetic nanoparticles mediated by cucurbit[n]urils
Xi-Long Qiu (2015)
10.1080/10611860290007559
By-passing of P-glycoprotein Using Immunoliposomes
J. Huwyler (2002)
10.1021/BC0498166
Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy.
Y. Bae (2005)
10.1021/nn101643u
Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles.
J. Huang (2010)
10.1002/smll.201102660
Size-dependent nonlinear weak-field magnetic behavior of maghemite nanoparticles.
Caroline de Montferrand (2012)
10.1021/ja402903h
Glutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.
Xinyu Wang (2013)
10.1021/nn501162x
Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy.
Ko-Jie Chen (2014)
10.1371/journal.pone.0043729
Evaluation of Environmental Safety Concentrations of DMSA Coated Fe2O3-NPs Using Different Assay Systems in Nematode Caenorhabditis elegans
Qiuli Wu (2012)
10.1038/nm0202-128
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
M. Guba (2002)
10.1093/toxsci/kfn121
Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology
Maxwell C. K. Leung (2008)
10.2147/IJN.S2824
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Xiang-hong Peng (2008)
10.1006/JCIS.1998.6053
Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study.
Babes (1999)
10.3390/cancers3011285
Glutathione in Cancer Cell Death
Á. Ortega (2011)
10.1021/ACSBIOMATERIALS.5B00253
Protective Effects of Bovine Serum Albumin on Superparamagnetic Iron Oxide Nanoparticles Evaluated in the Nematode Caenorhabditis elegans
L. Gonzalez-Moragas (2015)
10.1038/srep22965
The nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome
Philippa H. Harlow (2016)
10.1016/j.nano.2011.12.010
Electrostatic assembly of a DNA superparamagnetic nano-tool for simultaneous intracellular delivery and in situ monitoring.
Frédéric Geinguenaud (2012)
10.1016/j.cell.2009.02.024
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
J. Luo (2009)
10.1016/j.cis.2015.02.001
C. elegans as a tool for in vivo nanoparticle assessment.
L. Gonzalez-Moragas (2015)
10.1038/nrc3180
Treating metastatic cancer with nanotechnology
Avi Schroeder (2011)
10.1016/j.addr.2009.11.002
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.
O. Veiseh (2010)
10.1016/j.ijpharm.2010.10.011
Stimuli-responsive magnetic particles for biomedical applications.
S.F. Medeiros (2011)
10.3109/02656739509022457
Extracellular pH distribution in human tumours.
K. Engin (1995)
10.1038/nnano.2007.387
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
10.1021/la2006869
Interfacing multicellular organisms with polyelectrolyte shells and nanoparticles: a Caenorhabtidis elegans study.
R. T. Minullina (2011)
10.1002/chem.201405774
Viologen-templated arrays of cucurbit[7]uril-modified iron-oxide nanoparticles.
F. Benyettou (2015)
10.1007/S10847-005-2023-X
Cucurbit[6]uril as Ligand for the Complexation of Diamines, Diazacrown Ethers and Cryptands in Aqueous Formic Acid
H. Buschmann (2005)
10.1080/02656730500271692
Thermal ablation and high-temperature thermal therapy: Overview of technology and clinical implementation
C. Diederich (2005)
10.1103/PHYSREVE.71.011404
Influence of short-range interactions on the mesoscopic organization of magnetic nanocrystals.
Y. Lalatonne (2005)
10.1016/j.jconrel.2011.01.030
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.
R. Cheng (2011)
10.1021/bm4004805
Intracellular drug delivery nanocarriers of glutathione-responsive degradable block copolymers having pendant disulfide linkages.
Behnoush Khorsand (2013)



This paper is referenced by
10.1021/acsami.7b11423
Sequential Delivery of Doxorubicin and Zoledronic Acid to Breast Cancer Cells by CB[7]-Modified Iron Oxide Nanoparticles.
F. Benyettou (2017)
10.2147/IJN.S184723
A review of small molecules and drug delivery applications using gold and iron nanoparticles
Hossein Jahangirian (2019)
10.1016/j.bioorg.2020.103997
Synthesis of furocoumarin-stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer's disease.
Emmanuel N Agbo (2020)
10.1002/adhm.201801458
Magnetic Regulation of Thermo-Chemotherapy from a Cucurbit[7]uril-Crosslinked Hybrid Hydrogel.
Haishi Qiao (2019)
10.1080/10837450.2018.1551901
Preparation and characterization of angiopep-2 functionalized Ginsenoside-Rg3 loaded nanoparticles and the effect on C6 Glioma cells
Xiaomei Su (2019)
10.1007/s12274-020-2631-1
Real-time in situ magnetic measurement of the intracellular biodegradation of iron oxide nanoparticles in a stem cell-spheroid tissue model
Aurore B Van de Walle (2020)
10.1142/s1088424619501578
Glycosylated porphyrin-cucurbituril conjugate for photodynamic inactivation of bacteria and doxorubicin carriage for anticancer drug delivery
M. Özkan (2019)
10.1039/C7NJ04864E
Methotrexate-conjugated mPEG–PCL copolymers: a novel approach for dual triggered drug delivery
K. Rostamizadeh (2018)
10.1080/10610278.2019.1658874
Switchable peptide-equipped protein/cucurbit[7]uril supramolecular assembly for targeted drug delivery
Danhong Yan (2019)
10.1021/acsabm.9b00763
Cucurbit[7]uril-Anchored Porphyrin-Based Multifunctional Molecular Platform for Photodynamic Antimicrobial and Cancer Therapy
M. Özkan (2019)
10.1016/j.bioorg.2020.103702
Synthesis, α-glucosidase inhibition and antioxidant activity of the 7-carbo-substituted 5-bromo-3-methylindazoles.
M. Mphahlele (2020)
10.1016/j.saa.2018.01.007
The binding interaction of imazapyr with cucurbit[n]uril (n=6-8): Combined experimental and molecular modeling study.
Maali Saad Mokhtar (2018)
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