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Selective Growth Inhibition Of Cancer Cells With Doxorubicin-loaded CB-modified Iron-oxide Nanoparticles
F. Benyettou, H. Fahs, R. El-kharrag, R. Bilbeisi, B. Asma, Rachid Rezgui, L. Motte, Mazin Magzoub, Jérémy Brandel, J. Olsen, F. Piano, F. Piano, K. Gunsalus, K. Gunsalus, C. Platas-Iglesias, A. Trabolsi
Published 2017 · Chemistry
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Cucurbituril-modified iron-oxide nanoparticles (CBNPs) were loaded with doxorubicin hydrochloride (Dox) and tested as a drug delivery system. Dox was found to interact with the carbonyl-rich rims of the CB macrocycles adsorbed on the surface of the nanoparticles. The Dox-loaded nanoparticles (Dox@CBNPs) were stable at room temperature and physiological pH and released their Dox cargo under acidic conditions, in the presence of glutathione, or with heating. Dox@CBNPs reduced the viability of HeLa and three other cancer-derived cell lines in vitro at lower IC50 than free Dox. They were also nontoxic to C. elegans. The sensitivity of HeLa cells to Dox@CBNPs was enhanced when the temperature was elevated by application of an alternating magnetic field. Thus, Dox@CBNPs show promise as agents for the intracellular delivery of Dox to cancer cells, for the selective and controlled release of the drug, and, more generally, as a possible means of combining chemotherapeutic and hyperthermic treatment modalities.
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