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A Fluorescent Method Based On Magnetic Nanoparticles For Detection Of CGG Trinucleotide Repeat Genes

Ziqi Ren, Xiaoqian Zhu, Hehong Lv, Heng Liu, Hanping He, Xiuhua Zhang, Shengfu Wang

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A novel fluorescent sensor based on magnetic nanoparticles as the separator and short report DNA was designed and prepared for the detection of d(CGG)ntrinucleotide repeats. The method exhibited high selectivity and sensitivity, and excellent linear correlation from 100 pM to 150 nM, which is useful for the early diagnosis of neurodegenerative diseases.