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Highly Selective C–H Bond Activation Of N-arylbenzimidamide And Divergent Couplings With Diazophosphonate Compounds: A Catalyst-controlled Selective Synthetic Strategy For 3-phosphorylindoles And 4-phosphorylisoquinolines

Qiaolan Yang, Qiaolan Yang, C. Wu, J. Zhou, Guoxue He, H. Liu, Y. Zhou
Published 2019 · Chemistry

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A highly efficient synthetic strategy to construct 3-phosphorylindole and 4-phosphorylisoquinoline privileged scaffolds via selective C–H bond activations of N-phenylbenzimidamide and the subsequent divergent couplings with diazophosphonate compounds was achieved successfully by altering the Rh(III)/Ru(II) catalyst systems. This protocol features excellent chemoselectivity, wide substrate tolerance and mild reaction conditions, which might find wider application in the discovery of lead compounds in the future.
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