← Back to Search
Doxorubicin Release By Magnetic Inductive Heating And In Vivo Hyperthermia-chemotherapy Combined Cancer Treatment Of Multifunctional Magnetic Nanoparticles
P. Ha, Thi Tuyet Phuong Le, Thi Thanh Tra Le, T. Bui, H. N. Phạm, A. S. Ho, L. T. Nguyen
Published 2019 · Chemistry
Download PDFAnalyze on Scholarcy
Superparamagnetic iron oxide (Fe3O4) nanoparticles have been investigated for decades due to their potential biomedical applications. In this study, we synthesized, characterized and biologically tested multifunctional Fe3O4-based drug delivery systems for such an application. The nanosystems were successfully prepared with a small size, high saturation magnetization and high drug loading. The Fe3O4 core in an alternating magnetic field could generate enough heat for both effective hyperthermia therapy and doxorubicin release from the alginate shell for chemotherapy. Also, a folate factor was attached to the nanoparticles to help the system to enter and stay in the tumor cells for a longer time. In vivo experiments showed that the combined treatment was very helpful for the survival of lung cancer-bearing mice, especially in the case of the presence of a folate factor.
This paper references
Magnetic Nanoparticles for Cancer Diagnosis and Therapy
M. V. Yigit (2012)
Folate mediated self-assembled phytosterol-alginate nanoparticles for targeted intracellular anticancer drug delivery.
J. Wang (2015)
Folic acid conjugated Fe3O4 magnetic nanoparticles for targeted delivery of doxorubicin.
Suman Rana (2016)
Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
Shih-Hsiang Liao (2015)
Doxorubicin release triggered by alginate embedded magnetic nanoheaters: a combined therapy.
Séverine Brulé (2011)
Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields
M. Chorny (2010)
Magnetic Nanoparticles for Biomedical Applications
A. Pfeifer (2012)
Folate attached, curcumin loaded Fe3O4 nanoparticles: A novel multifunctional drug delivery system for cancer treatment
L. Hường (2016)
In vivo applications of magnetic nanoparticle hyperthermia
I. Hilger (2013)
Formulation design, preparation and characterization of multifunctional alginate stabilized nanodroplets.
Fatemeh Baghbani (2016)
The Preparation of CdTe-Fe3O4@CS Nanoparticles and its Application for Drug Carrying
L. Wang (2014)
Nanoparticles for biomedical imaging
Satish K Nune (2009)
Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications.
L. H. Reddy (2012)
Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy
B. Bahrami (2015)
High-frequency, magnetic-field-responsive drug release from magnetic nanoparticle/organic hybrid based on hyperthermic effect.
K. Hayashi (2010)
Sodium alginate-polyvinyl alcohol-bovin serum albumin coated Fe3O4 nanoparticles as anticancer drug delivery vehicle: Doxorubicin loading and in vitro release study and cytotoxicity to HepG2 and L02 cells.
G. Prabha (2017)
Folic acid-conjugated Fe3O4 magnetic nanoparticles for hyperthermia and MRI in vitro and in vivo
Q. Jiang (2014)
Folate-bovine serum albumin functionalized polymeric micelles loaded with superparamagnetic iron oxide nanoparticles for tumor targeting and magnetic resonance imaging.
H. Li (2015)
Structured superparamagnetic nanoparticles for high performance mediator of magnetic fluid hyperthermia: synthesis, colloidal stability and biocompatibility evaluation.
N. Thorat (2014)
Nanosized magnetofluorescent Fe3O4-curcumin conjugate for multimodal monitoring and drug targeting
L. Tran (2010)
Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy
T. Le (2018)
Synthesis and characterization of dextran coated magnetite nanoparticles for diagnostics and therapy
M. Khalkhali (2015)
Functional iron oxide magnetic nanoparticles with hyperthermia-induced drug release ability by using a combination of orthogonal click reactions.
T. T. Nguyen (2013)
Cytotoxicity and slow release of the anti-cancer drug doxorubicin from ZIF-8
Iane B. Vasconcelos (2012)
Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer.
Aziliz Hervault (2014)
Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell.
Fenghua Chen (2010)
Development of citrate-stabilized Fe3O4 nanoparticles: Conjugation and release of doxorubicin for therapeutic applications
Saumya Nigam (2011)
Iron oxide-based conjugates for cancer theragnostics
X. Nguyen (2012)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay.
N. Parker (2005)
Fluorescence properties of several chemotherapy drugs: doxorubicin, paclitaxel and bleomycin.
N. S. H. Motlagh (2016)
AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy.
M. Babincová (2002)
Preparation, characterization, and in vivo evaluation of doxorubicin loaded BSA nanoparticles with folic acid modified dextran surface.
Hequn Hao (2013)
Subnanometer local temperature probing and remotely controlled drug release based on azo-functionalized iron oxide nanoparticles.
A. Riedinger (2013)
Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle
Chung-Lin Yang (2017)
Bioapplications of boron nitride nanotubes.
G. Genchi (2015)
A smart, phase transitional and injectable DOX/PLGA-Fe implant for magnetic-hyperthermia-induced synergistic tumor eradication.
W. Gao (2016)
This paper is referenced by
Exosomes released by breast cancer cells under mild hyperthermic stress possess immunogenic potential and modulate polarization in vitro in macrophages.
Kacoli Sen (2020)
Properties and bioeffects of magneto–near infrared nanoparticles on cancer diagnosis and treatment
P. Ha (2020)
Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool
J. Jose (2019)
Review on magnetic nanoparticle-mediated hyperthermia for cancer therapy
Arunima Rajan (2020)
Increase of magnetic hyperthermia efficiency due to optimal size of particles: theoretical and experimental results
L. H. Nguyen (2020)