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Enhanced Anticancer Activity Of Multi-walled Carbon Nanotube-methotrexate Conjugates Using Cleavable Linkers.
Cristian Samorí, H. Ali-Boucetta, R. Sainz, C. Guo, F. Toma, C. Fabbro, T. Da Ros, M. Prato, K. Kostarelos, A. Bianco
Published 2010 · Medicine, Chemistry
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Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.
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