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Fluorescent Trimethyl-substituted Naphthyridine As A Ligand For C-C Mismatch Detection In CCG Trinucleotide Repeats.

Y. Sato, Atsuko Honjo, D. Ishikawa, S. Nishizawa, N. Teramae
Published 2011 · Chemistry, Medicine

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We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C-C mismatch present in the hairpin structures of (CCG)(n) trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.
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