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A New Class Of NO-donor Pro-drugs Triggered By γ-glutamyl Transpeptidase With Potential For Reno-selective Vasodilatation.

Q. Zhang, A. Kulczyńska, D. J. Webb, I. Megson, N. Botting
Published 2013 · Chemistry, Medicine

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This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
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