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Iron Oxide Nanoparticles Stabilized With Dendritic Polyglycerols As Selective MRI Contrast Agents

Daniel Nordmeyer, Patrick Stumpf, Dominic Gröger, Andreas Hofmann, Sven Enders, Sebastian B. Riese, Jens Dernedde, Matthias Taupitz, Ursula Rauch, Rainer Haag, Eckart Rühl, Christina Graf

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Superparamagnetic iron oxide nanoparticles with a dendritic polyglycerol (dPG) sulfate strongly bind to L- and P-selectin. Shielding of leukocytes reduces cell extravasation and binding to endothelial cells indicate inflammation specificity and thus, applicability as selective MRI contrast agent.