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Acetic Acid-promoted Cascade N-acyliminium Ion/aza-Prins Cyclization: Stereoselective Synthesis Of Functionalized Fused Tricyclic Piperidines

Rajiv T. Sawant, Marc Y. Stevens, Luke R. Odell

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A simple, efficient and stereoselective synthesis of novel fused piperidine/3,4-dihydroquinazolinone scaffolds via an imine/cyclization/N-acyliminium ion/aza-Prins cascade reaction sequence is described.