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VIVO Complexes With Antibacterial Quinolone Ligands And Their Interaction With Serum Proteins

Daniele Sanna, Valeria Ugone, Giuseppe Sciortino, Péter Buglyó, Zsolt Bihari, Péter László Parajdi-Losonczi, Eugenio Garribba

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VIVO complexes of quinolones were studied to couple their pharmacological activity with that of V. The interaction ofcis-VOL2(H2O) with apo-hTf, holo-hTf and HSA results in the formation {VOL2}y(Protein) species, withy= 1–3,viaHis binding of the proteins.