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Ca2+- And Calmodulin-dependent Protein Phosphorylation In Rat Lacrimal Gland

D A Dartt, V J Guerina, M Donowitz, L Taylor, G W G Sharp

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Ca2+, in homogenized lacrimal glands, enhanced phosphorylation of several peptides. Phosphorylation of two of these peptides was further stimulated by addition of the Ca2+-binding protein calmodulin and decreased by trifluoperazine, an inhibitor of Ca2+-calmodulin-dependent activity. Thus, Ca2+-calmodulin-dependent protein kinases and their substrates are present in lacrimal gland and could have an important role in lacrimal-gland function.