Online citations, reference lists, and bibliographies.
← Back to Search

Lysophosphatidic Acid: Mitogen And Motility Factor.

F. V. van Leeuwen, B. Giepmans, L. V. van Meeteren, W. Moolenaar
Published 2003 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of cell proliferation, migration and survival. It does so by activating its cognate G-protein-coupled receptors, four of which have been identified. LPA receptors couple to at least three distinct G-proteins and thereby activate multiple signal transduction pathways, particularly those initiated by the small GTPases Ras, Rho and Rac. Our recent work has shown that LPA signals Rac activation via the Tiam1 GDP/GTP exchange factor and thereby stimulates cell migration. Here we discuss recent progress in our understanding of LPA action.

This paper is referenced by
Capacity to Promote Tumor Cell Motility and Metastasis Nm 23-H 1 Binds to Gelsolin and Inactivates Its Actin-Severing
Natascia Marino (2013)
Growth factors and corneal epithelial wound healing
F. Yu (2010)
A painful link between the TRPV1 channel and lysophosphatidic acid.
S. Morales-Lázaro (2015)
Constitutive autotaxin transcription by Nmyc‐amplified and non‐amplified neuroblastoma cells is regulated by a novel AP‐1 and SP‐mediated mechanism and abrogated by curcumin
Antonietta R. Farina (2012)
Different Mechanisms Regulate Lysophosphatidic Acid (LPA)-dependent Versus Phorbol Ester-dependent Internalization of the LPA1 Receptor*
N. Urs (2008)
Lysophosphatidic acid (LPA) induces the expression of VEGF leading to protection against apoptosis in B-cell derived malignancies.
X. Hu (2008)
Role of Lysophospholipids in Cell Growth and Survival
X. Fang (2007)
Lysophospholipids in development: Miles apart and edging in
J. Saba (2004)
Coca-Cola Company
S. Baah (2003)
Characterisation of human airway smooth muscle cell lysophosphatidic acid receptors in asthma and health
M. Valente (2014)
Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.
J. H. Seo (2010)
Class II Phosphoinositide 3-Kinases as Novel Drug Targets.
M. Falasca (2017)
Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1.
B. Salhia (2005)
Lysophosphatidic acid induces osteocyte dendrite outgrowth.
Sue A. Karagiosis (2007)
G. Doria (2007)
Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.
R. Veluthakal (2009)
Functional lipidomics: Lysophosphatidic acid as a target for molecular diagnosis and therapy of ovarian cancer
J. Tanyi (2005)
Autotaxin Promotes the Expression of Matrix Metalloproteinase-3 via Activation of the MAPK Cascade in Human Fibrosarcoma HT-1080 Cells
A. Haga (2009)
Effect of STAT3 on Lysophosphatidic Acid-Induced Oral Cancer Cell Invasion
Zi Hae Song (2019)
Chemoattraction to lysophosphatidic acid does not require a change in membrane potential in Tetrahymena thermophila
Thomas J Lampert (2011)
Rho GTPases control ciliary epithelium cells proliferation and progenitor profile induction in vivo.
C. B. Del Debbio (2014)
The regulation of cellular trafficking of the human lysophosphatidic acid receptor 1: Identification of the molecular determinants required for receptor trafficking
N. Urs (2007)
Lysophosphatidic Acid and Sphingosine-1-Phosphate Activation of G-Protein-Coupled Receptors
T. Mutoh (2010)
Rho GTPase and cAMP/Protein Kinase A Signaling Mediates Myocilin-induced Alterations in Cultured Human Trabecular Meshwork Cells*
X. Shen (2008)
Lysophosphatidic acid increases in vitro maturation efficiency via uPA-uPAR signaling pathway in cumulus cells.
S. Hwang (2018)
Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes
K. Kotarsky (2006)
[Lysophosphatidic acid as a potential target for treatment and molecular diagnosis of epithelial ovarian cancers].
J. Tanyi (2009)
Caractérisation du rôle de la voie Jak/STAT dans la réponse mitogénique des récepteurs couplés aux protéines G
F. Duhamel (2005)
Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action
I. Berdichevets (2010)
Promotive action of lysophosphatidic acid on proliferation of rat embryonic neural stem cells and their differentiation to cholinergic neurons in vitro.
Hui-Lin Cui (2006)
Cdc 42 3-Kinase-Dependent Activation of Rac 1 and Restitution through Phosphatidylinositol Enhances Intestinal Epithelial Cell Formyl Peptide Receptor-1 Activation
B. Babbin (2007)
Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor.
K. Xu (2007)
See more
Semantic Scholar Logo Some data provided by SemanticScholar