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Brain PH In Migraine: An In Vivo Phosphorus-31 Magnetic Resonance Spectroscopy Study

K M A Welch, Steven R Levine, Giovanni D'Andrea, J A Helpern

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The intracellular pH (pHi) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vaso-dilatation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.