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Pain, Tenderness, Wheal And Flare Induced By Substance-P, Bradykinin And 5-Hydroxytryptamine In Humans

K. Jensen, C. Tuxen, U. Pedersen-Bjergaard, I. Jansen
Published 1991 · Medicine

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The algesic effect of substance-P with and without the addition of bradykinin or 5-hydroxytryptamine was studied in 13 healthy volunteers. Test substances dissolved in saline were injected into the temporal muscle and the forearm skin and the effects compared with those of saline. In the temporal muscle, none of the test substances induced more pain than saline, but substance-P with bradykinin lowered the pressure pain threshold by 18% (p < 0.02). All test substances induced pain, wheal and flare in the forearm skin. Substance-P induced a more pronounced flare reaction than bradykinin, whereas the latter induced more pain than substance-P. This dissociation between pain and flare may indicate that C-fibres in the human skin represent more than one type of nociceptor.
This paper references
10.1016/B978-0-08-021308-8.51076-0
1062 – EFFECT OF SUBSTANCE P ON RESISTANCE AND CAPACITANCE VESSELS IN THE HUMAN FOREARM
B. Pernow (1977)
10.1007/BF00500324
Lack of algesic effect of substance P on paravascular pain receptors
F. Lembeck (2004)
10.1016/0196-9781(90)90141-Q
Pain and tenderness in human temporal muscle induced by bradykinin and 5-hydroxytryptamine
K. Jensen (1990)
10.1002/ANA.410230214
Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
P. J. Goadsby (1988)
Response of the human temporal circulation to substance P in vitro and in situ
R Håkanson (1985)
Pressure -
K Jensen
thresholds and thermal nociceptive thresholds in chronic tension - type headache
Dalsgaard C-J (1989)
10.1111/1523-1747.EP12520912
Inhibition of axon reflex vasodilatation by topically applied capsaicin.
J. Bernstein (1981)
10.1177/0333102489009S1075
Pressure Pain Thresholds and Thermal Nociceptive Thresholds in Chronic Tension-Type Headache
M. Langemark (1989)
10.1016/0304-3959(88)90277-1
Pericranial muscle tenderness and pressure-pain threshold in the temporal region during common migraine
K. Jensen (1988)
10.1007/BF00500282
Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation
F. Lembeck (2004)
10.1016/0304-3959(86)90162-4
Peptide-containing nerve fibres in human extracranial tissue: a morphological basis for neuropeptide involvement in extracranial pain?
R. Uddman (1986)
10.1016/0304-3959(89)90078-X
Substance P and peripheral inflammatory hyperalgesia
M. Nakamura-Craig (1989)
10.1002/ANA.410160202
The neurobiology of vascular head pain
M. Moskowitz (1984)
10.1016/0304-3959(86)90235-6
Pressure-pain threshold in human temporal region. Evaluation of a new pressure algometer
K. Jensen (1986)
Edvinsson L , Olesen J . Pain and tenderness in human temporal muscle induced by bradykinin and 5 - hydroxytryptamine
K Jensen (1990)
10.1002/ANA.410200409
Localization and effects of neuropeptide Y, vasoactive intestinal polypeptide, substance P, and calcitonin gene–related peptide in human temporal arteries
I. Jansen (1986)
10.1113/jphysiol.1983.sp014543
Structure‐activity relationships for some substance P‐related peptides that cause wheal and flare reactions in human skin.
J. Foreman (1983)
Chemosensitive pain fibres and inflammation
G Jancso (1980)
10.1038/262784a0
Substance P and analgesia
John M. Stewart (1976)
Further immunohistochemical studies of substance P in the peripheral nervous system
C-J Dalsgaard (1983)
10.1016/0196-9781(90)90142-R
Pain, wheal and flare in human forearm skin induced by bradykinin and 5-hydroxytryptamine
K. Jensen (1990)
10.1111/j.1476-5381.1986.tb16246.x
Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex
P. Barnes (1986)
10.1016/0304-3959(87)91226-7
Pericranial muscle tenderness and pressure pain threshold in the temporal region of migraine patients
Kræn Blume Jensen (1987)
Response of the human temporal circulation to substance P in vitro and in situ. In: Håkanson R, Sundler F eds Tachykinin antagonists
I Jansen (1985)
10.1111/1523-1747.EP12515092
Flare and itch induced by substance P in human skin.
O. Haegermark (1978)
10.1016/0196-9781(89)90006-5
Algesia and local responses induced by neurokinin A and substance P in human skin and temporal muscle
U. Pedersen-Bjergaard (1989)
The weak excitation of some cutaneous receptors in cats and rabbits by synthetic substance P [proceedings].
M. Fitzgerald (1979)
10.1111/j.1476-5381.1987.tb11381.x
Sensory neuropeptide effects in human skin
R. Fuller (1987)



This paper is referenced by
10.1016/S0304-3959(99)00026-3
Experimental human muscle pain and muscular hyperalgesia induced by combinations of serotonin and bradykinin
V. Babenko (1999)
10.1046/J.1523-1747.2000.00142.X
Acute effects of substance P and calcitonin gene-related peptide in human skin--a microdialysis study.
C. Weidner (2000)
10.1111/joor.12449
Effect of experimental anterior temporalis muscle pain on jaw movements.
Magda Amhamed (2016)
10.1016/S1537-5897(03)00045-4
Review: central sensitization and musculoskeletal pain
M. H. Bement (2003)
10.1054/JPAI.2002.126610
Sympathetic-independent bradykinin mechanical hyperalgesia induced by subdiaphragmatic vagotomy in the rat.
S. Khasar (2002)
10.1523/JNEUROSCI.23-34-10784.2003
Opioid Modulation of Scratching and Spinal c-fos Expression Evoked by Intradermal Serotonin
H. Nojima (2003)
10.1016/S0196-9781(02)00101-8
Does nociceptin play a role in pain disorders in man?
H. Mørk (2002)
10.1007/S11916-000-0051-1
Clinical and experimental aspects of temporomandibular disorders
P. Svensson (2000)
10.1111/ncn3.12356
Views on migraine pathophysiology: Where does it start?
Lars Edvinsson (2020)
10.1016/J.EJPHAR.2005.06.057
Inhibition of acute nociceptive responses in rat spinal cord by a bradykinin B1 receptor antagonist.
Rachel K Conley (2005)
10.1016/j.pain.2013.01.003
Characterisation and mechanisms of bradykinin-evoked pain in man using iontophoresis
Kathryn J. Paterson (2013)
10.1016/0028-3908(95)00136-0
Activation of 5-HT2A receptors potentiates pain produced by inflammatory mediators
F. Abbott (1996)
10.3390/ijms20071596
Ion Channels Involved in Substance P-Mediated Nociception and Antinociception
C. Chang (2019)
10.3390/brainsci10010030
Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache
Andrea Carmine Belin (2020)
10.1016/0006-3223(92)90187-5
Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: Preliminary findings
M. Demitrack (1992)
10.1007/s004820050048
Substanz P, Somatostatin und monoaminerge Transmitter in der Zerebrospinalflüssigkeit von Patienten mit chronischer idiopathischer Trigeminusneuralgie
M. Strittmatter (2006)
10.1111/j.1600-0404.1993.tb08074.x
References
(1993)
10.1007/978-3-642-18891-6_14
Role of Tachykinins in Neurogenic Inflammation of the Skin and Other External Surfaces
A. Rawlingson (2004)
Development of safety limits for load carriage in adults
M. Fergenbaum (2007)
10.1007/978-3-642-27814-3_76-2
Skin Aging: A Generalization of the Micro-inflammatory Hypothesis
P. Giacomoni (2010)
10.1016/S0304-3959(03)00093-9
Innocuous jaw movements increase c-fos expression in trigeminal sensory nuclei produced by masseter muscle inflammation
J. Ro (2003)
10.1053/eujp.1998.0103
Experimental human muscle pain induced by intramuscular injections of bradykinin, serotonin, and substance P
V. Babenko (1999)
10.1053/eujp.2000.0214
Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin
G. Lischetzki (2001)
10.1038/nchembio0709-436
Open access chemical and clinical probes to support drug discovery.
A. Edwards (2009)
10.1016/J.VPH.2005.08.025
How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom.
S. Costa (2006)
10.1016/j.jpain.2009.07.004
ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury.
R. Walder (2010)
Substance IP Potentiates the A of Adenosine
A. Gaspardone ()
10.1046/j.1526-4610.1997.3704211.x
Cerebrospinal Fluid Neuropeptides and Monoaminergic Transmitters in Patients With Trigeminal Neuralgia
Matthias Strittmatter (1997)
10.1159/000070707
The Effect of the Nitric Oxide Synthase Inhibitor N-Nitro-L-Arginine-Methyl Ester on Neuropeptide-Induced Vasodilation and Protein Extravasation in Human Skin
M. Klede (2003)
10.1155/1996/654071
Pathophysiology of Headaches with a Prominent Vascular Component
J. Pareja (1996)
10.1080/03009740600865980
Fundamentals of muscle pain, referred pain, and deep tissue hyperalgesia
T. Graven-Nielsen (2006)
10.1016/S1090-3801(97)90035-5
Referred pain is dependent on sensory input from the periphery: A psychophysical study
R. Laursen (1997)
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