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Management Of Malignant Pleural Effusions-What Is New.

Rajesh Thomas, B. Roy, F. Maldonado, Y. Lee
Published 2019 · Medicine

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Malignant pleural effusion (MPE) is a common and challenging problem. Patients affected by MPE have a poor prognosis and suffer from breathlessness and impaired quality of life. The management of MPE has barely changed for many decades; however, recent research has driven new paradigms in the diagnosis and treatment of MPE and stimulated novel concepts that are being evaluated in many ongoing studies. This review provides an overview of recent advances in the diagnosis of MPE, including new cytopathology and imaging techniques, and the landmark studies that provide a solid evidence base to support the use of indwelling pleural catheters as first-line treatment in MPE. Lingering management dilemmas, including optimal chest drainage tube and role of surgery in MPE, and key knowledge gaps that are the focus of ongoing research are also highlighted.
This paper references
10.1136/bmjresp-2015-000123
Complications of indwelling pleural catheter use and their management
M. M. S. Lui (2016)
10.1159/000485934
Procedures Performed during Hospitalizations for Malignant Pleural Effusions: Data from the 2012 National Inpatient Sample
M. Fortin (2018)
10.1016/j.athoracsur.2012.02.100
Treatment of malignant pleural effusion: a cost-effectiveness analysis.
V. Puri (2012)
10.3109/01902148.2012.731715
Use of a drug eluting pleural catheter for pleurodesis
A. Tremblay (2012)
10.1510/icvts.2009.211516
Malignant pleural effusion in the presence of trapped lung. Five-year experience of PleurX tunnelled catheters.
C. Efthymiou (2009)
10.1097/LBR.0000000000000186
Pleuroscopic Pleurodesis Combined With Tunneled Pleural Catheter for Management of Malignant Pleural Effusion: A Prospective Observational Study
Z. Boujaoude (2015)
10.2214/AJR.154.3.2106209
CT in differential diagnosis of diffuse pleural disease.
A. Leung (1990)
10.1001/jama.2012.5535
Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: the TIME2 randomized controlled trial.
H. E. Davies (2012)
10.1378/chest.13-1908
Quality-adjusted survival following treatment of malignant pleural effusions with indwelling pleural catheters.
D. Ost (2014)
10.1378/chest.11-0724
Fractured indwelling pleural catheters.
E. Fysh (2012)
10.1016/j.lungcan.2017.01.019
A randomized controlled trial comparing indwelling pleural catheters with talc pleurodesis (NVALT-14).
R. Boshuizen (2017)
10.1378/CHEST.129.2.362
Single-center experience with 250 tunnelled pleural catheter insertions for malignant pleural effusion.
A. Tremblay (2006)
10.1002/(SICI)1097-0142(19991115)86:10<1992::AID-CNCR16>3.0.CO;2-M
A randomized comparison of indwelling pleural catheter and doxycycline pleurodesis in the management of malignant pleural effusions
J. Putnam (1999)
10.1111/j.1349-7006.2012.02223.x
Frequent inactivation of the BAP1 gene in epithelioid‐type malignant mesothelioma
Yoshie Yoshikawa (2012)
10.1056/NEJMoa1012740
Intrapleural use of tissue plasminogen activator and DNase in pleural infection.
Najib M. Rahman (2011)
10.1259/bjr/55980445
Multidetector CT imaging of pleura: comparison of two contrast infusion protocols.
V. Raj (2011)
10.1016/S0954-6111(98)90315-8
Treatment of malignant pleural effusion: pleurodesis using a small percutaneous catheter. A prospective randomized study.
P. Clementsen (1998)
10.1378/CHEST.104.5.1486
The incidence of pleural effusion in a well-defined region. Epidemiologic study in central Bohemia.
M. Marel (1993)
10.1159/000497212
Pleural Cryobiopsy versus Flexible Forceps Biopsy in Subjects with Undiagnosed Exudative Pleural Effusions Undergoing Semirigid Thoracoscopy: A Crossover Randomized Trial (COFFEE Trial)
S. Dhooria (2019)
10.1164/rccm.201704-0809OC
Randomized Controlled Trial of Urokinase versus Placebo for Nondraining Malignant Pleural Effusion
Eleanor K. Mishra (2018)
10.1016/j.athoracsur.2007.11.039
Management of malignant pleural effusions using the Pleur(x) catheter.
W. Warren (2008)
10.1001/jama.2015.16840
Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial.
N. Rahman (2015)
10.1097/JTO.0b013e31829e7ef9
Clinical Characteristics of Patients with Malignant Pleural Mesothelioma Harboring Somatic BAP1 Mutations
M. Zauderer (2013)
10.1136/thx.2008.100545
Thoracic ultrasound in the diagnosis of malignant pleural effusion
N. R. Qureshi (2008)
10.4187/respcare.02738
A Randomized Trial Comparing the Diagnostic Yield of Rigid and Semirigid Thoracoscopy in Undiagnosed Pleural Effusions
S. Dhooria (2014)
10.1001/jama.2017.17426
Effect of an Indwelling Pleural Catheter vs Talc Pleurodesis on Hospitalization Days in Patients With Malignant Pleural Effusion: The AMPLE Randomized Clinical Trial
Rajesh Thomas (2017)
10.1136/thx.2010.136994
Management of a malignant pleural effusion: British Thoracic Society pleural disease guideline 2010
M. Roberts (2010)
10.1136/thoraxjnl-2014-205285
Predicting survival in malignant pleural effusion: development and validation of the LENT prognostic score
A. Clive (2014)
10.1378/chest.13-2481
Comparing cost of indwelling pleural catheter vs talc pleurodesis for malignant pleural effusion.
E. Penz (2014)
10.7326/0003-4819-114-4-271
Thoracoscopy for the diagnosis of pleural disease.
R. Menzies (1991)
10.1378/chest.14-1701
Predictors of clinical use of pleurodesis and/or indwelling pleural catheter therapy for malignant pleural effusion.
E. Fysh (2015)
10.1378/CHEST.117.1.87
Pleural fluid pH as a predictor of pleurodesis failure: analysis of primary data.
J. Heffner (2000)
10.1097/SLA.0000000000000903
Extrapleural Pneumonectomy in the Treatment of Epithelioid Malignant Pleural Mesothelioma: Novel Prognostic Implications of Combined N1 and N2 Nodal Involvement Based on Experience in 529 Patients
D. Sugarbaker (2014)
10.1016/j.chest.2018.02.038
Air in the Pleural Cavity Enhances Detection of Pleural Abnormalities by CT Scan.
E. Fysh (2018)
10.1038/ng.855
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
Matthew J Bott (2011)
10.1136/bmjresp-2017-000270
Randomised controlled trial to compare the diagnostic yield of positron emission tomography CT (PET-CT) TARGETed pleural biopsy versus CT-guided pleural biopsy in suspected pleural malignancy (TARGET trial)
D. de Fonseka (2018)
10.1136/thoraxjnl-2012-203043
Pleurodesis outcome in malignant pleural mesothelioma
E. Fysh (2013)
10.1016/j.athoracsur.2014.01.057
Nonspecific pleuritis: optimal duration of follow-up.
Z. Depew (2014)
10.1164/ajrccm.162.5.ats8-00
[Management of malignant pleural effusions].
R. Loddenkemper (2005)
Pleural metastatic tumours and effusions. Frequency and pathogenic mechanisms in a post-mortem series.
F. Rodríguez-Panadero (1989)
10.4103/1742-6413.170726
Guidelines for cytopathologic diagnosis of epithelioid and mixed type malignant mesothelioma. Complementary statement from the International Mesothelioma Interest Group, also endorsed by the International Academy of Cytology and the Papanicolaou Society of Cytopathology
A. Hjerpe (2015)
10.1378/chest.13-3057
Catheter tract metastasis associated with indwelling pleural catheters.
Rajesh Thomas (2014)
10.1378/CHEST.120.1.19
Use of small-bore vs large-bore chest tubes for treatment of malignant pleural effusions.
W. Parulekar (2001)
10.1159/000351796
The Use of Indwelling Pleural Catheters for the Management of Malignant Pleural Effusion - Direct Costs in a Dutch Hospital
R. Boshuizen (2013)
10.1016/S0140-6736(14)60418-9
Efficacy and cost of video-assisted thoracoscopic partial pleurectomy versus talc pleurodesis in patients with malignant pleural mesothelioma (MesoVATS): an open-label, randomised, controlled trial
R. Rintoul (2014)
10.1097/MCP.0000000000000174
Physiology of breathlessness associated with pleural effusions
Rajesh Thomas (2015)
10.1016/j.acra.2017.03.006
Can CT and MR Shape and Textural Features Differentiate Benign Versus Malignant Pleural Lesions?
Elena Peña (2017)
10.1111/resp.13207_400
EARLY PLEURODESIS VIA INDWELLIMG PLEURAL CATHETER WITH TALC FOR MALIGNANT EFFUSIONS: THE EPITOME STUDY
S. Muruganandan (2017)
10.1016/0003-4975(91)91298-A
Thoracoscopy in the diagnosis and management of recurrent pleural effusions.
J. Hucker (1991)
10.1136/bmjresp-2018-000293
Pre-EDIT: protocol for a randomised feasibility trial of elastance-directed intrapleural catheter or talc pleurodesis (EDIT) in malignant pleural effusion
Geoffrey A Martin (2018)
10.1378/chest.12-3103
Clinical outcomes of indwelling pleural catheter-related pleural infections: an international multicenter study.
E. Fysh (2013)
10.1097/MCP.0b013e3282fe9a04
Image-guided pleural biopsy
N. Rahman (2008)
10.1378/CHEST.107.6.1598
Diagnosis of pleural effusions. Experience with clinical studies, 1986 to 1990.
M. Marel (1995)
10.1111/resp.12441
Pleuroscopic cryoprobe biopsies of the pleura: A feasibility and safety study
Rajesh Thomas (2015)
10.1097/PAT.0b013e32835bc848
A diagnosis of malignant pleural mesothelioma can be made by effusion cytology: results of a 20 year audit
A. Segal (2013)
10.1378/CHEST.127.3.909
Phase III intergroup study of talc poudrage vs talc slurry sclerosis for malignant pleural effusion.
C. Dresler (2005)
10.1158/0008-5472.CAN-14-1008
Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.
Guangwu Guo (2015)
10.1186/s12967-015-0485-1
BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma
H. Alakus (2015)
10.1148/radiol.12110872
Malignant pleural disease: diagnosis by using diffusion-weighted and dynamic contrast-enhanced MR imaging--initial experience.
J. Coolen (2012)
10.1111/resp.12675
Diagnostic value of radiological imaging pre‐ and post‐drainage of pleural effusions
J. Corcoran (2016)
10.1007/s12032-015-0612-0
The palliative treatment with intrapleural streptokinase in patients with multiloculated malignant pleural effusion: a double-blind, placebo-controlled, randomized study
Ozkan Saydam (2015)
10.1183/09031936.00164706
Use of tunnelled catheters for malignant pleural effusions in patients fit for pleurodesis
A. Tremblay (2007)
10.1055/s-0030-1269836
Optimal chest drain size: the rise of the small-bore pleural catheter.
E. Fysh (2010)
10.1136/bmjopen-2016-012795
OPTIMUM: a protocol for a multicentre randomised controlled trial comparing Out Patient Talc slurry via Indwelling pleural catheter for Malignant pleural effusion vs Usual inpatient Management
P. Sivakumar (2016)
10.1007/s13665-019-0224-9
Malignant Pleural Mesothelioma: an Update for Pulmonologists
C. Sidhu (2019)
10.1177/0218492311410874
Streptokinase for malignant pleural effusions: a randomized controlled study
E. Okur (2011)
10.1378/chest.10-1868
Rapid pleurodesis for malignant pleural effusions: a pilot study.
C. Reddy (2011)
10.1111/resp.12777
Histopathology of removed indwelling pleural catheters from patients with malignant pleural diseases
Claire L. Tobin (2016)
10.1089/jpm.2009.0220
Treatment of malignant pleural effusion: PleuRx catheter or talc pleurodesis? A cost-effectiveness analysis.
Aaron M Olden (2010)
10.1016/S2213-2600(15)00220-9
Spontaneous pneumothorax: time to rethink management?
O. Bintcliffe (2015)
10.1093/ejcts/ezy258
ERS/EACTS statement on the management of malignant pleural effusions
A. Bibby (2019)
10.3978/j.issn.2072-1439.2013.11.28
Guidelines for the diagnosis and treatment of malignant pleural mesothelioma.
N. van Zandwijk (2013)
10.1378/chest.11-2657
Indwelling pleural catheters reduce inpatient days over pleurodesis for malignant pleural effusion.
E. Fysh (2012)
10.1164/rccm.201701-0097LE
A Novel Drug-Eluting Indwelling Pleural Catheter for the Management of Malignant Effusions.
R. Bhatnagar (2018)
10.1097/JTO.0000000000000471
High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma
Masaki Nasu (2015)
10.1378/chest.14-0013
Derivation and validation of a CT scan scoring system for discriminating malignant from benign pleural effusions.
J. M. Porcel (2015)
10.1164/rccm.201607-1404OC
Randomized Trial of Pleural Fluid Drainage Frequency in Patients with Malignant Pleural Effusions. The ASAP Trial
M. Wahidi (2017)
10.1159/000358842
A New Method for Performing Continuous Manometry during Pleural Effusion Drainage
M. Salamonsen (2014)
10.1177/021849230801600208
Management of Malignant Pleural Effusion Associated with Trapped Lung Syndrome
R. Qureshi (2008)
10.1378/chest.14-0394
Talc pleurodesis through indwelling pleural catheters for malignant pleural effusions: retrospective case series of a novel clinical pathway.
L. Ahmed (2014)
10.1111/resp.12328
Interventional therapies for malignant pleural effusions: The present and the future
Rajesh Thomas (2014)
10.1111/resp.12496
Clinical features and survival of lung cancer patients with pleural effusions
J. M. Porcel (2015)
10.1016/S2213-2600(18)30288-1
Aggressive versus symptom-guided drainage of malignant pleural effusion via indwelling pleural catheters (AMPLE-2): an open-label randomised trial.
S. Muruganandan (2018)
10.1136/thx.2009.133504
Chemotherapy should not be withheld from patients with an indwelling pleural catheter for malignant pleural effusion
A. Morel (2010)
10.1007/s11606-010-1472-0
Efficacy and Safety of Tunneled Pleural Catheters in Adults with Malignant Pleural Effusions: A Systematic Review
Margaret E. M. Van Meter (2010)
10.1016/S2213-2600(18)30421-1
Routine monitoring with pleural manometry during therapeutic large-volume thoracentesis to prevent pleural-pressure-related complications: a multicentre, single-blind randomised controlled trial.
Robert J Lentz (2019)
10.1097/01.mcp.0000129756.87090.55
Pleurodesis for malignant pleural effusions: current controversies and variations in practices
S. West (2004)
10.1378/chest.14-0820
Accuracy of fluorodeoxyglucose-PET imaging for differentiating benign from malignant pleural effusions: a meta-analysis.
J. M. Porcel (2015)
10.1136/bmjopen-2016-013213
Protocol of the PLeural Effusion And Symptom Evaluation (PLEASE) study on the pathophysiology of breathlessness in patients with symptomatic pleural effusions
Rajesh Thomas (2016)
10.1378/CHEST.112.3.709
Analysis of tube thoracostomy performed by pulmonologists at a teaching hospital.
N. Collop (1997)
10.1513/AnnalsATS.201411-511OC
A Quality Improvement Intervention to Reduce Indwelling Tunneled Pleural Catheter Infection Rates.
Christopher R Gilbert (2015)
10.1097/LBR.0000000000000001
Infections Associated With Tunnelled Indwelling Pleural Catheters in Patients Undergoing Chemotherapy
E. Mekhaiel (2013)
10.1164/rccm.201807-1415ST
Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline
D. Feller-Kopman (2018)
10.1378/chest.14-2401
Intrapleural Fibrinolysis for the Treatment of Indwelling Pleural Catheter-Related Symptomatic Loculations: A Multicenter Observational Study.
Rajesh Thomas (2015)
10.1002/1097-0142(19890915)64:6<1218::AID-CNCR2820640609>3.0.CO;2-V
Small bore catheter drainage and sclerotherapy for malignant pleural effusions
L. A. Parker (1989)



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