Online citations, reference lists, and bibliographies.
← Back to Search

Long-term Survival Of Children With End-stage Renal Disease.

S. McDonald, J. Craig
Published 2004 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
BACKGROUND Although renal-replacement therapy for children with end-stage renal disease has been used for several decades, data on patients' long-term survival are sparse. METHODS We examined the long-term survival of all children and adolescents who were under 20 years of age when renal-replacement therapy commenced (study period, April 1963 through March 2002), using data from the Australia and New Zealand Dialysis and Transplant Registry. Survival was analyzed with the use of Kaplan-Meier methods and age-standardized mortality rates. Risk factors for death were analyzed with the use of Cox regression analysis with time-dependent covariates. RESULTS A total of 1634 children and adolescents were followed for a median of 9.7 years. The long-term survival rate among children requiring renal-replacement therapy was 79 percent at 10 years and 66 percent at 20 years. Mortality rates were 30 times as high as for children without end-stage renal disease. Risk factors for death were a young age at the time renal-replacement therapy was initiated (especially for children under 1 year of age, among whom the risk was four times as high as for children 15 to 19 years of age) and treatment with dialysis (which was associated with a risk more than four times as high as for renal transplantation). Overall, a trend toward improved survival was observed over the four decades of the study. CONCLUSIONS Despite improvement in long-term survival, mortality rates among children requiring renal-replacement therapy remain substantially higher than those among children without end-stage renal disease. Increasing the proportion of children treated with renal transplantation rather than with dialysis can improve survival further.
This paper references
10.1136/adc.63.1.35
Long term outcome of treatment of end stage renal failure.
P. Henning (1988)
Treatment modality patterns and transplantation among the United States pediatric end-stage renal disease population: a longitudinal study.
P. Held (1991)
10.1016/S0022-3476(98)70199-4
Attitudes of pediatric nephrologists to management of end-stage renal disease in infants.
D. Geary (1998)
10.1056/NEJM199912023412303
Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant.
R A Wolfe (1999)
10.1016/S0022-3476(00)90044-1
Long-term outcome of peritoneal dialysis in infants.
S. Ledermann (2000)
10.1097/00007890-200004150-00035
Pretransplant dialysis status and outcome of renal transplantation in North American children: a NAPRTCS Study. North American Pediatric Renal Transplant Cooperative Study.
A. Vats (2000)
10.1177/089686080002000513
The Effect of CAPD on the Lipid Profile of Pediatric Patients
S. Bakkaloglu (2000)
10.1007/s004670050022
Risk factors for hyperlipidemia in long-term pediatric renal transplant recipients
D. Silverstein (2000)
10.1007/s004670000303
Severe left ventricular hypertrophy in pediatric dialysis: prevalence and predictors
M. Mitsnefes (2000)
10.1053/AJKD.2001.22083
Risk factors for mortality in infants and young children on dialysis.
E. Wood (2001)
10.1136/adc.87.6.511
Outcome of reaching end stage renal failure in children under 2 years of age
M. Coulthard (2002)
10.1067/MPD.2002.125910
Cardiovascular mortality in children and young adults with end-stage kidney disease.
R. Parekh (2002)
10.1093/NDT/17.12.2212
Survival of recipients of cadaveric kidney transplants compared with those receiving dialysis treatment in Australia and New Zealand, 1991-2001.
S. McDonald (2002)
10.1046/J.1523-1755.2002.00156.X
Mortality and causes of death of end-stage renal disease in children: a Dutch cohort study.
J. Groothoff (2002)
10.1046/J.1523-1755.2003.00788.X
A prospective cohort study of incident maintenance dialysis in children: an NAPRTC study.
M. Leonard (2003)
10.1111/j.1467-842X.2003.tb00420.x
Cause of death in patients with end‐stage renal disease: assessing concordance of death certificates with registry reports
S. Li (2003)
10.1007/BF01213344
Renal replacement therapy for end-stage renal failure before 2 years of age
J. Ehrich (2005)



This paper is referenced by
10.1007/978-3-030-66861-7_34
Neurocognitive Functioning in Pediatric Dialysis
S. Hooper (2021)
10.2147/RRU.S289853
Immunological Risk Factors in Paediatric Kidney Transplantation
F. Friedersdorff (2021)
Assessment of Zinc- alfa2 glycoprotein (ZAG) and Lipase Maturation Factor 1 (LMF1) concentration in children with chronic kidney disease.
D. Roszkowska-Bjanid (2021)
10.3389/fphar.2021.653525
CYP3A5 and UGT1A9 Polymorphisms Influence Immunosuppressive Therapy in Pediatric Kidney Transplant Recipients
P. Krall (2021)
10.3389/fped.2021.702719
Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease—A Pediatric Perspective
Andrea Grund (2021)
10.1007/s00467-021-05071-2
The impact of donor and recipient sex on kidney allograft survival in pediatric transplant recipients
N. Mudalige (2021)
10.1007/s00467-021-05182-w
The causes and consequences of paediatric kidney disease on adult nephrology care
R. Pepper (2021)
10.1111/jpc.15533
Barriers to pre‐emptive kidney transplantation in New Zealand children
H. Weststrate (2021)
10.3389/fspor.2021.688383
Longitudinal Follow-Up on Cardiopulmonary Exercise Capacity Related to Cardio-Metabolic Risk Factors in Children With Renal Transplants
Susanne Westphal Ladfors (2021)
10.1007/s00467-021-04972-6
Hemodialysis (HD) dose and ultrafiltration rate are associated with survival in pediatric and adolescent patients on chronic HD—a large observational study with follow-up to young adult age
V. Gotta (2021)
10.1016/j.jpurol.2021.05.021
Long-term outcomes of living-donor kidney transplant children weighing less than 15 kg: Comparison of the surgical approach.
Y. Aoki (2021)
10.1007/978-3-030-66861-7_39
Long-Term Outcome of Chronic Dialysis in Children
M. Honda (2021)
10.1007/978-3-030-66861-7_49
Evaluating and Preparing the Pediatric Dialysis Patient for Kidney Transplantation
S. Amaral (2021)
10.1007/s00345-020-03537-w
Comparison of the outcomes of the pediatric kidney transplantation between recipients below and above 15 kg: a single center retrospective study
T. Loubersac (2021)
10.3389/fcell.2021.678524
The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney
Craig E. Higgins (2021)
10.1007/s00467-021-04945-9
Survival and transplant outcomes among young children requiring kidney replacement therapy
N. Larkins (2021)
10.1007/s00467-021-05145-1
Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies
Ryoko Harada (2021)
10.1007/s00467-021-04928-w
Ten-year trends in epidemiology and outcomes of pediatric kidney replacement therapy in Europe: data from the ESPN/ERA-EDTA Registry
M. Bonthuis (2021)
10.1007/978-3-642-27843-3_129-1
Chronic Kidney Disease – Mineral and Bone Disorder (CKD-MBD)
R. Shroff (2021)
10.1007/978-3-030-66861-7_31
Management of Hypertension in Pediatric Dialysis Patients
E. Wühl (2021)
10.1007/s00467-020-04887-8
Dilatation of the aorta in children with advanced chronic kidney disease
Sophie Quennelle (2021)
10.1111/nep.13886
Incidence and predictors of vascular events following end‐stage kidney disease in childhood
A. L. Le Page (2021)
10.3389/fsurg.2021.649418
Pediatric Challenges in Robot-Assisted Kidney Transplantation
Julien Grammens (2021)
10.1111/petr.13999
Factors associated with long‐term graft survival in pediatric kidney transplant recipients
Adrish Anand (2021)
10.1007/s00467-021-05102-y
Reducing the burden of cardiovascular disease in children with chronic kidney disease: prevention vs. damage limitation
R. Shroff (2021)
10.1007/s00467-019-04457-7
Primary causes of kidney disease and mortality in dialysis-dependent children
Yusuke Okuda (2020)
10.30968/rbfhss.2020.114.0511
Factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease
A. M. Paiva (2020)
10.22037/uj.v16i7.5759
Chronic Kidney Disease in Iran: First Report of the National Registry in Children and Adolescences.
N. Ataei (2020)
10.17219/acem/121928
Kidney transplantation and other methods of renal replacement therapy in children: 30 years of observations in one center.
A. Medyńska (2020)
10.1111/petr.13860
Kidney transplantation in low weight pediatric recipients from adult donors: The short‐ And the long‐term outcomes
S. Raza (2020)
10.1111/petr.13710
Nocturnal hypertension and left ventricular hypertrophy in pediatric renal transplant recipients in South India
P. Pais (2020)
10.2215/CJN.07060619
Low Serum Bicarbonate and CKD Progression in Children.
Denver D Brown (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar