← Back to Search
Sterically Stabilized Liposomes: Improvements In Pharmacokinetics And Antitumor Therapeutic Efficacy.
D. Papahadjopoulos, T. Allen, A. Gabizon, E. Mayhew, K. Matthay, S. Huang, K. Lee, M. Woodle, D. Lasič, C. Redemann
Published 1991 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect is substantially greater than that observed previously with conventional liposomes and is associated with a more than 5-fold prolongation of liposome circulation time in blood, a marked decrease in uptake by tissues such as liver and spleen, and a corresponding increased accumulation in implanted tumors. These and other properties described here have expanded considerably the prospects of liposomes as an effective carrier system for a variety of pharmacologically active macromolecules.
This paper references
Liposomes in the Therapy of Infectious Disease and Cancer
T. Daemen (1988)
Liposomes in the therapy of infectious diseases and cancer
G. López-Berestein (1989)
Liposomes in the therapy of infectious diseases and cancer: Lopez-Berestein, G. and Fidler, I.J. (Eds.), 500 pp. Alan R. Liss, New York, 1989. USD 96.00, ISBN 0-8451-2688-1
F. Borek (1990)
Liposomes as Drug Carriers: Recent Trends and Progress: Ed. G. Gregoriadis, John Wiley and Sons, Chichester, 1988, 885 pp., ISBN 047-916-544, £95
R. Duncan (1989)
Liposomes as drug carriers : recent trends and progress
G. Gregoriadis (1988)
This paper is referenced by
Gadolinium-based contrast agents for magnetic resonance cancerimaging: Gadolinium-based CA for MR cancer imaging
Z. Zhou (2013)
Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes.
R. Kinne (1995)
Apoptotic cell death in activated monocytes following incorporation of clodronate‐liposomes
C. B. Schmidt‐Weber (1996)
Nonviral Delivery for Genomic Therapy of Cancer
N. Templeton (2008)
Enzyme therapeutics for systemic detoxi fi cation ☆ F
Yang Liu (2015)
Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome.
Q. Chen (2004)
Functionalization of Liposomes with Hydrophilic Polymers Results in Macrophage Uptake Independent of the Protein Corona
C. Weber (2019)
Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy
A. Gabizon (2001)
Polyethylene glycol modification: relevance of improved methodology to tumour targeting.
G. E. Francis (1996)
MRI of tumor angiogenesis
T. Barrett (2007)
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
L. R. Hirsch (2003)
Targeting Dendritic Cells with Antigen-Containing Liposomes
C. L. van Broekhoven (2004)
Effects of Drug Hydrophobicity on Liposomal Stability
D. R. Khan (2008)
Synthesis of segmentally deuterated poly(acetyliminoethylene) lipopolymers, material for neutron scattering and NMR studies
Peter Kuhn (1998)
Recent advances in liposome technologies and their applications for systemic gene delivery.
Structural and metabolic consequences of liposome-lipoprotein interactions.
Accumulation of Protein-Loaded Long-Circulating Micelles and Liposomes in Subcutaneous Lewis Lung Carcinoma in Mice
V. Weissig (2004)
Interaction of cationic colloids at the surface of J774 cells: a kinetic analysis.
P. Chenevier (2000)
Structure and design of polymeric surfactant-based drug delivery systems.
V. Torchilin (2001)
Design and gene delivery activity of modified polyethylenimines.
R. Kircheis (2001)
Long-circulating sterically stabilized liposomes in the treatment of infections.
I. Bakker-Woudenberg (2005)
A targeted liposome delivery system for combretastatin A4: formulation optimization through drug loading and in vitro release studies.
Ramakrishna Nallamothu (2006)
Sterically stabilized superparamagnetic liposomes for MR imaging and cancer therapy: pharmacokinetics and biodistribution.
V. Plassat (2007)
SELECTIVE DRUG DELIVERY TO TUMOR BY THERMOSENSITIVE LIPOSOMES AND LOCAL HYPERTHERMIA
N. Russian (2008)
Nanotemplate-Engineered Nanoparticles Containing Gadolinium for Magnetic Resonance Imaging of Tumors
D. Zhu (2008)
Phase I and Pharmacokinetic Study of Pegylated Liposomal CKD-602 in Patients with Advanced Malignancies
W. Zamboni (2009)
Photodynamic therapy selectively enhances liposomal doxorubicin uptake in sarcoma tumors to rodent lungs
C. Cheng (2010)
Effect of Protein Coatings on the Delivery Performance of Liposomes.
Emily F. Rabinsky (2011)
Hyperthermia Mediated Drug Delivery using Thermosensitive Liposomes and MRI-Controlled Focused Ultrasound
Robert M. T. Staruch (2014)
23 Nanoparticles for Drug Delivery
M. Hans (2006)
RNA Information Gene Diseases: Nano-RNA-Based Medical Devices with Corporate Chemotherapy and Gene Therapy
Yoichi Fujii (2014)
Liposomal drug delivery system
J. Kim (2016)See more