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Sterically Stabilized Liposomes: Improvements In Pharmacokinetics And Antitumor Therapeutic Efficacy.

D. Papahadjopoulos, T. Allen, A. Gabizon, E. Mayhew, K. Matthay, S. Huang, K. Lee, M. Woodle, D. Lasič, C. Redemann
Published 1991 · Chemistry, Medicine

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The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect is substantially greater than that observed previously with conventional liposomes and is associated with a more than 5-fold prolongation of liposome circulation time in blood, a marked decrease in uptake by tissues such as liver and spleen, and a corresponding increased accumulation in implanted tumors. These and other properties described here have expanded considerably the prospects of liposomes as an effective carrier system for a variety of pharmacologically active macromolecules.
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