Online citations, reference lists, and bibliographies.
← Back to Search

Parallel Human Genome Analysis: Microarray-based Expression Monitoring Of 1000 Genes.

M. Schena, D. Shalon, R. Heller, A. Chai, P. Brown, R. Davis
Published 1996 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Microarrays containing 1046 human cDNAs of unknown sequence were printed on glass with high-speed robotics. These 1.0-cm2 DNA "chips" were used to quantitatively monitor differential expression of the cognate human genes using a highly sensitive two-color hybridization assay. Array elements that displayed differential expression patterns under given experimental conditions were characterized by sequencing. The identification of known and novel heat shock and phorbol ester-regulated genes in human T cells demonstrates the sensitivity of the assay. Parallel gene analysis with microarrays provides a rapid and efficient method for large-scale human gene discovery.
This paper references



This paper is referenced by
Gene expression data analysis using novel methods: Predicting time delayed correlations and evolutionarily conserved functional modules
R. Balasubramaniyan (2005)
Expression microarray technology as a tool in cancer research
A. Kokko (2006)
[Microarrays for detection of HBV and HDV].
Z. Sun (2004)
10.11113/JT.V43.780
A Study on Gene Selection and Classification Algorithms for Classification of Microarray Gene Expression Data
L. Yeo (2005)
10.1016/S1046-2023(03)00156-7
Application of the S-score algorithm for analysis of oligonucleotide microarrays.
R. T. Kerns (2003)
10.1093/bioinformatics/btg165
Noise Sampling Method: An ANOVA Approach Allowing Robust Selection of Differentially Regulated Genes Measured by DNA Microarrays
S. Draghici (2003)
10.5897/JMPR10.886
DNA markers in the authentication of Traditional Chinese Medicine
Y. Liu (2014)
10.14264/UQL.2014.316
Discovery of novel downstream target genes regulated by the hedgehog pathway
W. J. Ingram (2002)
10.1007/S10330-005-0359-8
Genes Expression Profile Difference in Peripheral Blood Between Esophageal Carcinoma Patients and Normal Subjects
Qian Li-juan (2005)
The application of transcriptomics in the comparative safety assessment of (GMO-derived) plant products
E. Kok (2008)
Development and application of Dissociable Antibody Microarray (DAMA) staining technique
Guanyuan Fu (2009)
STATISTICAL METHODS IN MICROARRAY DATA ANALYSIS
Liping Huang (2009)
Gene Expression Studies of Hematologic Malignacies
A. Andersson (2005)
10.3724/SP.J.1145.2011.00422
Clustering GO Terms Applied to Differential Gene Expression Detection*: Clustering GO Terms Applied to Differential Gene Expression Detection*
Qiuju Tang (2012)
10.1186/2040-2392-4-23
Increased gene expression of FOXP1 in patients with autism spectrum disorders
Wei-Hsien Chien (2013)
10.1038/4302
A genome-wide functional assay of signal transduction in living mammalian cells
M. Whitney (1998)
V . A System Approach to Modeling , Forecasting , and Management of Financial and Economic Processes /
M. Zgurovsky (2014)
10.1007/s00424-006-0164-4
Intra- and interindividual variation in gene expression in human adipose tissue
Esther A. van Beek (2006)
Analysis of Gene Expression in the K 562-n High Tumorigenitic Human . Leukemia Cell Une
Shu-qing (2007)
Identification of drug-resistance predictive genes in breast cancer neoadjuvant chemotherapy
L. Mittempergher (2009)
10.1007/s12575-010-9026-8
Collection of Epithelial Cells from Rodent Mammary Gland Via Laser Capture Microdissection Yielding High-Quality RNA Suitable for Microarray Analysis
J. McGinley (2010)
10.1146/ANNUREV.BIOENG.1.1.265
Nucleic acid biotechnology.
C. Roth (1999)
Serielle Analyse der Genexpression (SAGE): Etablierung, Statistik und Reliabilität Zur Erlangung des akademischen Grades Doctor medicinae (Dr. med.) vorgelegt der Medizinischen Fakultät Charité der Humboldt-Universität zu Berlin Stefanie Castell aus München
Aus der Abteilung (2006)
10.1093/abbs/gmq127
Protein microarrays for systems biology
L. Yang (2011)
10.3389/fpls.2017.00367
Gene Classification and Mining of Molecular Markers Useful in Red Clover (Trifolium pratense) Breeding
Jan Ištvánek (2017)
Modeling and Simulation of Lab-on-a-Chip Systems
Y. Wang (2005)
10.1002/(SICI)1098-2299(199707/08)41:3/4<193::AID-DDR9>3.0.CO;2-G
Impact of genomics on diagnostic medicine
J. Burczak (1997)
Oligonucleotide Microarrays Microbial Communities by Using 50-Mer Biodegradation and Biotransformation in Detection of Genes Involved in
Sung-Keun Rhee (2003)
10.1038/labinvest.2015.81
MicroRNAs in the pathobiology of sarcomas
Anne E. Sarver (2015)
Use of Bioinformatics to Investigate Abiotic Stress in Arabidopsis and to Design Primers for Pathogen Detection
S. Mane (2007)
10.1095/biolreprod.104.030395
Gene Expression Profiling of Embryonic Stem Cells Leads to Greater Understanding of Pluripotency and Early Developmental Events1
R. R. Rao (2004)
10.1152/PHYSIOLGENOMICS.2000.3.2.93
A novel, sensitive detection system for high-density microarrays using dendrimer technology.
R. Stears (2000)
See more
Semantic Scholar Logo Some data provided by SemanticScholar