← Back to Search
EXECUTER1- And EXECUTER2-dependent Transfer Of Stress-related Signals From The Plastid To The Nucleus Of Arabidopsis Thaliana
K. P. Lee, C. Kim, F. Landgraf, K. Apel
Published 2007 · Medicine, Biology
Download PDFAnalyze on Scholarcy
Shortly after the release of singlet oxygen (1O2), drastic changes in nuclear gene expression occur in the conditional flu mutant of Arabidopsis that reveal a rapid transfer of signals from the plastid to the nucleus. In contrast to retrograde control of nuclear gene expression by plastid signals described earlier, the primary effect of 1O2 generation in the flu mutant is not the control of chloroplast biogenesis but the activation of a broad range of signaling pathways known to be involved in biotic and abiotic stress responses. This activity of a plastid-derived signal suggests a new function of the chloroplast, namely that of a sensor of environmental changes that activates a broad range of stress responses. Inactivation of the plastid protein EXECUTER1 attenuates the extent of 1O2-induced up-regulation of nuclear gene expression, but it does not fully eliminate these changes. A second related nuclear-encoded protein, dubbed EXECUTER2, has been identified that is also implicated with the signaling of 1O2-dependent nuclear gene expression changes. Like EXECUTER1, EXECUTER2 is confined to the plastid. Inactivation of both EXECUTER proteins in the ex1/ex2/flu triple mutant is sufficient to suppress the up-regulation of almost all 1O2-responsive genes. Retrograde control of 1O2-responsive genes requires the concerted action of both EXECUTER proteins within the plastid compartment.
This paper references
Pathways of plastid-to-nucleus signaling.
S. Rodermel (2001)
The role of EDS1 (enhanced disease susceptibility) during singlet oxygen-mediated stress responses of Arabidopsis.
Christian Ochsenbein (2006)
Substrate-Dependent and Organ-Specific Chloroplast Protein Import in Planta Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.015008.
C. Kim (2004)
Imaging of photo-oxidative stress responses in leaves.
M. Fryer (2002)
An unexpected plethora of trehalose biosynthesis genes in Arabidopsis thaliana.
B. Leyman (2001)
Trends Plant Sci 6:471–478
S Rodermel (2001)
Cross-talk between singlet oxygen- and hydrogen peroxide-dependent signaling of stress responses in Arabidopsis thaliana
C. Laloi (2007)
NADPH oxidase AtrbohD and AtrbohF genes function in ROS‐dependent ABA signaling in Arabidopsis
J. Kwak (2003)
Trends Plants Sci
YD Liu (2001)
The Genetic Basis of Singlet OxygenInduced Stress Responses of Arabidopsis thaliana
D. Wagner (2004)
Annu Rev Plant Physiol Plant Mol Biol
RG opdenCamp (1999)
Evolution of organelles and eukaryotic genomes.
L. Bogorad (1975)
THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.
K. Asada (1999)
Biochemistry & Molecular Biology of Plants
B. Buchanan (2002)
PHOTOPROTECTION REVISITED: Genetic and Molecular Approaches.
K. Niyogi (1999)
Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thaliana.
A. Danon (2005)
Trends Plants Sci
J Müller (2000)
FLU: A negative regulator of chlorophyll biosynthesis in Arabidopsis thaliana
R. Meskauskiene (2001)
Current perspectives of singlet oxygen detection in biological environments.
A. A. Gorman (1992)
Reactive Oxygen Species Play a Role in Regulating a Fungus–Perennial Ryegrass Mutualistic Interaction[W]
Aiko Tanaka (2006)
Chlorophyll precursors are signals of chloroplast origin involved in light induction of nuclear heat-shock genes.
J. Kropat (1997)
Phosphorylation of 1-Aminocyclopropane-1-Carboxylic Acid Synthase by MPK6, a Stress-Responsive Mitogen-Activated Protein Kinase, Induces Ethylene Biosynthesis in Arabidopsisw⃞
Y. Liu (2004)
Detection of singlet oxygen and superoxide with fluorescent sensors in leaves under stress by photoinhibition or UV radiation.
É. Hideg (2002)
Reactive oxygen species produced by NADPH oxidase regulate plant cell growth
J. Foreman (2003)
pH, abscisic acid and the integration of metabolism in plants under stressed and non-stressed conditions: cellular responses to stress and their implication for plant water relations.
A. Netting (2000)
Singlet oxygen induced DNA damage.
H. Sies (1992)
Trends Plants Sci 5:199–206
T Eulgem (2000)
The WRKY superfamily of plant transcription factors.
T. Eulgem (2000)
Dorsal anterior cingulate cortex: A role in reward-based decision making
G. Bush (2001)
Progress in Plastid Research. (Book Reviews: The Plastids. Their Chemistry, Structure, Growth and Inheritance)
J. Kirk (1979)
Photochem Photobiol B 14:159–176
AA Gorman (1992)
Rapid Induction of Distinct Stress Responses after the Release of Singlet Oxygen in Arabidopsis Online version contains Web-only data. Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.014662.
R. G. op den Camp (2003)
Trehalose and trehalase in plants: recent developments
J. Müller (1995)
Carotenoid-deficient maize seedlings fail to accumulate light-harvesting chlorophyll a/b binding protein (LHCP) mRNA.
S. Mayfield (1984)
Cryptochrome-1-dependent execution of programmed cell death induced by singlet oxygen in Arabidopsis thaliana
A. Danon (2006)
Reactive oxygen species: metabolism, oxidative stress, and signal transduction.
K. Apel (2004)
Hydrogen peroxide signalling.
S. Neill (2002)
Signaling pathways from the chloroplast to the nucleus
C. Beck (2005)
Chloroplast to nucleus communication triggered by accumulation of Mg-protoporphyrinIX
Å. Strand (2003)
Trends Plants Sci 6:510–513
B Leyman (2001)
Trends Plant Sci
L Bogorad (2001)
This paper is referenced by
Enhanced levels of vitamin B(6) increase aerial organ size and positively affect stress tolerance in Arabidopsis.
M. Raschke (2011)
Assessment of Subcellular ROS and NO Metabolism in Higher Plants: Multifunctional Signaling Molecules
Sukhmeen Kaur Kohli (2019)
Plastid Signaling During the Plant Life Cycle
T. Pfannschmidt (2013)
Biogenesis and homeostasis of chloroplasts and other plastids
P. Jarvis (2013)
Chloroplast Dysfunction Causes Multiple Defects in Cell Cycle Progression in the Arabidopsis crumpled leaf Mutant1[C][W]
Elodie Hudik (2014)
Chemicals to induce plastid signals in Arabidopsis seedlings
Z. Zhang (2015)
The roles of tetrapyrroles in plastid retrograde signaling and tolerance to environmental stresses
Z. Zhang (2015)
Breeding for Sustainability: Utilizing High-Throughput Genomics to Design Plants for a New Green Revolution
Noureddine Benkeblia (2016)
In vitro, antioxidant and scavenging activities of Hibiscus rosa sinensis crude extract
Faten R. Abdel Ghaffar (2012)
Transcriptional Regulation of Tetrapyrrole Biosynthesis in Arabidopsis thaliana
K. Kobayashi (2016)
Programmed cell death in plants: new insights into redox regulation and the role of hydrogen peroxide.
Ilya Gadjev (2008)
Systemic Photooxidative Stress Signalling
M. Carmody (2013)
Cytoplasmic genome substitution in wheat affects the nuclear-cytoplasmic cross-talk leading to transcript and metabolite alterations
C. Crosatti (2013)
Tackling the Heat-Stress Tolerance in Crop Plants: A Bioinformatics Approach
Sudhakar Reddy Palakolanu (2014)
Effects of ZnCl2 on ROS generation, plasma membrane properties, and changes in protein expression in grapevine root explants
Vladimír Řepka (2016)
Piecing the Puzzle Together: The Central Role of Reactive Oxygen Species and Redox Hubs in Chloroplast Retrograde Signaling.
D. Leister (2019)
The molecular mechanism of zinc and cadmium stress response in plants
Ya-Fen Lin (2012)
Chromium stress response effect on signal transduction and expression of signaling genes in rice.
Ngoc-Nam Trinh (2014)
The Low Molecular Mass Photosystem II Protein PsbTn Is Important for Light Acclimation1[OPEN]
Y. Chen (2018)
Regulation of vitamin B6 biosynthesis in Arabidopsis thaliana
S. Boycheva (2014)
Singlet oxygen initiates a plastid signal controlling photosynthetic gene expression
Mike T. Page (2017)
The ROS Wheel: Refining ROS Transcriptional Footprints1[OPEN]
P. Willems (2016)
Characterization of singlet oxygen-accumulating mutants isolated in a screen for altered oxidative stress response in Chlamydomonas reinhardtii
B. B. Fischer (2010)
Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls
Q. Wei (2008)
Redox regulation in photosynthetic organisms: signaling, acclimation, and practical implications.
C. Foyer (2009)
A Mediator of Singlet Oxygen Responses in Chlamydomonas reinhardtii and Arabidopsis Identified by a Luciferase-Based Genetic Screen in Algal Cells[W]
N. Shao (2013)
Coordination of two different genomes in response to light and stress
Louise Norén Lindbäck (2016)
The Plant Immunity Regulating F-Box Protein CPR1 Supports Plastid Function in Absence of Pathogens
Christiane Hedtmann (2017)
Nitric oxide regulates chlorophyllide biosynthesis and singlet oxygen generation differently between Arabidopsis and barley.
Z. Zhang (2018)
Reactive oxygen species, abiotic stress and stress combination.
Feroza K Choudhury (2017)
Linking mitochondrial and chloroplast retrograde signalling in plants
Yan Wang (2020)
Effect of Photoperiod on Redox Regulation of Phenotypic Plasticity and Cellular Growth in Chlorella vulgaris
L. Hollis (2014)See more