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Detection Of Pharmaceutical Contaminations Of River, Pond, And Tap Water From Cologne (Germany) And Surroundings.

U. Jux, Rainer M Baginski, H. Arnold, M. Krönke, P. Seng
Published 2002 · Chemistry, Medicine

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A method for the simultaneous determination of polar pharmaceutical compounds in water is presented. Samples from 27 rivers and ponds were investigated for contents of Gemfibrocil, a lipid blood regulating compound, Clofibric acid, a metabolite of lipid regulating compounds (Clofibrat, Etofibrat, Etofyllinclofibrat), antirheumatics (Diclofenac, Ibuprofen, Ketoprofen, Indomethacin, Fenoprofen) and Sarkosin-N-(phenylsulfonyl) (SPS), a metabolite of a corrosion inhibiting agent. In addition water samples were investigated for some main metabolites of Ibuprofen, 2-[4-(2-hydroxy-2-methylpropyl)phenyl]propionic acid (hydroxy-ibuprofen) and 2-[4-(2-carboxypropyl)phenyl]propionic acid (carboxy-ibuprofen), which are excreted after oral intake. For gas chromatographic analysis the drugs were converted into their methyl-derivatives by "on column" reaction with TMSH, TMAH and "pre column" with diazomethane. The detection limits with TMSH were in the same range or lower than those with diazomethane or TMAH. The compound most frequently found was SPS which was only absent in waters with natural surroundings. Diclofenac could be detected in 10 out of 27 water samples in concentrations of up to 15 micrograms/l. In contrast, none of the pharmaceuticals investigated were present in 8 drinking water samples from Cologne and surroundings. Though concentrations measured were far below pharmacological doses, the data suggest a steady flux of these drugs into the environment.
This paper references
Handbook of derivatives for chromatography
K. Blau (1978)
10.1007/BF02319701
Trans-esterification of fatty acids from microorganisms and human blood serum by trimethylsulfonium hydroxide (TMSH) for GC analysis
K. Mueller (1990)
GASCHROMATOGRAPHISCHE BESTIMMUNG VON ACIDEN PESTIZIDEN IN WASSER NACH METHYLIERUNG MIT TRIMETHYLSULFONIUMHYDROXID
H. Farber (1991)
10.1016/0021-9673(92)85061-W
Intra-injector formation of methyl esters from phenoxy acid pesticides
I. Brondz (1992)
Vorkommen von Clofibrinsäure in aquatischen System: Führt die therapeutische Anwendung zu einer Belastung von Oberflächen-, Grund- und Trinkwasser?
Hans-Jürgen Stan (1994)
Identifizierung eines polaren, wasserwerksgängigen Sulfonamids : Analytik, Vorkommen und Verhalten während der Trinkwasseraufbereitung
T. Knepper (1995)
Vorkommen von polaren organischen Kontaminanten im Berliner Trinkwasser
T. Heberer (1996)
Nachweis von Arzneimittelrückständen in Kläranlagen und Fliessgewässern
M. Stumpf (1996)
Auftreten von Phenylsulfonamiden in Kläranlagen-, Oberflächen- und Trinkwässern
T. Knepper (1996)
10.1080/03067319708031398
Determination of Clofibric Acid and N-(Phenylsulfonyl)-Sarcosine in Sewage, River and Drinking Water
T. Heberer (1997)
10.1002/(SICI)1521-401X(199809)26:5<272::AID-AHEH272>3.0.CO;2-O
Occurrence and Distribution of Organic Contaminants in the Aquatic System in Berlin. Part I: Drug Residues and other Polar Contaminants in Berlin Surface and Groundwater
T. Heberer (1998)
Isolierung von Ibuprofen-Metaboliten und deren Bedeutung als Kontaminanten der aquatischen Umwelt
M. Stumpf (1998)
Nachweis ausgewählter Pharmaka in Bremer Wässern
Vera Suling (2000)



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10.1016/J.CHERD.2020.12.025
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S. A. Mirzaee (2021)
10.1016/j.jwpe.2021.102325
Ozonation of diclofenac in a laboratory scale bubble column: Intermediates, mechanism, and mass transfer study
Surabhi Patel (2021)
10.1007/978-3-030-69090-8_1
Remediation of Emerging Contaminants
N. Morin-Crini (2021)
10.1016/j.envres.2021.112243
Sustainable green nanoadsorbents for remediation of pharmaceuticals from water and wastewater: A critical review.
Afzal Husain Khan (2021)
10.1007/978-3-030-52395-4_10
Pharmaceutical and Personal Care Products in the Aquatic Environment and Wastewater Treatment by Advanced Oxidation Processes
E. Saggioro (2021)
10.1016/j.ecolind.2021.108172
The possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review
Seyyed Abbas Mirzaee (2021)
10.1007/978-3-030-70757-6_11
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(2021)
10.1016/j.scitotenv.2020.136572
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Rana Morsi (2020)
10.1016/j.scitotenv.2020.140848
Anti-inflammatory drugs in the Vistula River following the failure of the Warsaw sewage collection system in 2019.
P. Stepnowski (2020)
10.1016/j.ecoenv.2020.111106
Biological uptake, depuration and biochemical effects of diclofenac and carbamazepine in Carassius carassius.
M. Nkoom (2020)
10.1016/j.cej.2019.122826
Degradation of polar and non-polar pharmaceutical pollutants in water by solar assisted photocatalysis using hydrothermal TiO2-SnS2
M. Kovačić (2020)
10.1016/j.envres.2020.110366
Multi-residue analysis of 20 mycotoxins including major metabolites and emerging mycotoxins in freshwater using UHPLC-MS/MS and application to freshwater ponds in Flanders, Belgium.
T. Goessens (2020)
10.1016/j.scitotenv.2019.134057
Occurrence, interactive effects and ecological risk of diclofenac in environmental compartments and biota - a review.
P. Sathishkumar (2020)
10.1016/j.jece.2019.103586
Enhanced ibuprofen removal by heterogeneous-Fenton process over Cu/ZrO2 and Fe/ZrO2 catalysts
S. Hussain (2020)
10.1007/s00216-020-02509-8
Monitoring pharmaceuticals in the aquatic environment using enzyme-linked immunosorbent assay (ELISA)—a practical overview
G. Jaria (2020)
10.1016/J.SEPPUR.2019.115967
The oxidative degradation of diclofenac using the activation of peroxymonosulfate by BiFeO3 microspheres—Kinetics, role of visible light and decay pathways
Fuman Han (2020)
10.1016/j.matchemphys.2019.122403
Green fabrication of silver imprinted titania / silica nanospheres as robust visible light-induced photocatalytic wastewater purification
Z. A. Alrowaili (2020)
10.1007/s11356-020-11328-4
Diclofenac photodegradation with the Perovskites BaFeyTi1-yO3 as catalysts
A. Rodrigues (2020)
10.1016/J.POWTEC.2018.12.097
Adsorption of diclofenac sodium onto commercial organoclay: Kinetic, equilibrium and thermodynamic study
G. S. Maia (2019)
10.1016/j.chemosphere.2019.06.184
Prolonged exposure of Stenotrophomonas maltophilia biofilms to trace levels of clofibric acid alters antimicrobial tolerance and virulence.
I. B. Gomes (2019)
10.1016/j.chemosphere.2019.01.057
Highly efficient modified lead oxide electrode using a spin coating/electrodeposition mode on titanium for electrochemical treatment of pharmaceutical pollutant.
Sahar Boukhchina (2019)
Uklanjanje diklofenaka s \(H_{2}SO_{4}\)-funkcionaliziranim aktivnim ugljenom od ljuske oraha
Ivana Miljević (2019)
10.1016/J.TALANTA.2019.05.058
Portable and low-cost biosensor towards on-site detection of diclofenac in wastewater.
Christine Schirmer (2019)
10.1016/j.envres.2019.108609
Effects of diclofenac and salicylic acid exposure on Lemna minor: Is time a factor?
G. D. Alkimin (2019)
10.1016/j.chemosphere.2019.125141
Interactive effects of diclofenac and copper on bioconcentration and multiple biomarkers in crucian carp (Carassius auratus).
Zhengxin Xie (2020)
10.1007/s11356-018-04072-3
Bioconcentration, behavioral, and biochemical effects of the non-steroidal anti-inflammatory drug diclofenac in Daphnia magna
M. Nkoom (2019)
10.1016/j.scitotenv.2019.135568
Pharmaceuticals residues and xenobiotics contaminants: Occurrence, analytical techniques and sustainable alternatives for wastewater treatment.
Milina de Oliveira (2019)
10.1007/s11356-018-1913-6
Comparison of different advanced degradation processes for the removal of the pharmaceutical compounds diclofenac and carbamazepine from liquid solutions
A. Capodaglio (2018)
10.3390/CATAL8120604
Application of BiOX Photocatalysts in Remediation of Persistent Organic Pollutants
R. B. Arthur (2018)
10.1016/j.jhazmat.2018.06.018
Photocatalytic degradation of ibuprofen over BiOCl nanosheets with identification of intermediates.
R. B. Arthur (2018)
10.2478/acph-2018-0024
Analysis of diclofenac in water samples using in situ derivatization-vortex-assisted liquid-liquid microextraction with gas chromatography-mass spectrometry
S. Aydın (2018)
10.2174/0929867325666181108094222
Pharmaceutical Mixtures: Still A Concern For Human And Environmental Health.
G. Simu (2018)
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