Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effects Of Basic Fibroblast Growth Factor (bFGF) On Early Stages Of Tendon Healing: A Rat Patellar Tendon Model

B. Chan, S. Fu, L. Qin, K. Lee, C. Rolf, K. Chan
Published 2000 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
We studied the effects of basic fibroblast growth factor (bFGF) on cell proliferation, type III collagen expression, ultimate stress and the pyridinoline content in the early stages of healing in rat patellar tendon. 96 male Sprague Dawley rats were injected with increasing doses of basic fibroblast growth factor (bFGF) at 3 days after a "window defect" was induced in the mid-part of the patellar tendon. They were killed at 7 and 14 days after the injury. A dose-dependent increase in the number of proliferating cells and the level of expression of type III collagen was demonstrated at only 7 days post-injury. On the other hand, we found no effects of bFGF on ultimate stress and the pyridinoline content of healing tendons. Only time significantly affected both strength-associated parameters. We showed that in vivo supplementation with bFGF affected the initial events of healing such as cell proliferation and type III collagen expression.
This paper references
10.1002/JOR.1100130203
Rabbit medial collateral ligament scar weakness is associated with decreased collagen pyridinoline crosslink density
C. Frank (1995)
10.1115/1.2891206
The use of a laser micrometer system to determine the cross-sectional shape and area of ligaments: a comparative study with two existing methods.
S. Woo (1990)
10.1016/0003-2697(84)90101-5
Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography.
D. Eyre (1984)
10.1097/00003086-199709000-00025
Fibroblast Growth Factor and Epidermal Growth Factor Receptors in Ligament Healing
V. Panossian (1997)
The effect of basic fibroblast growth factor on primary healing of the defect in canine anterior cruciate ligament
D Kobayashi (1995)
10.1016/0014-4827(87)90018-8
Prostaglandin binding does not require direct cell-cell contact during chick myogenesis in vitro.
R. Hausman (1987)
10.1002/JOR.1100160512
Pyridinoline in relation to ultimate stress of the patellar tendon during healing: An animal study
B. Chan (1998)
Growth factor expression in healing rabbit medial collateral and anterior cruciate ligaments.
J. Lee (1998)
10.1006/BBRC.1994.2824
Detection of elevated basic fibroblast growth factor during early hours of in vitro angiogenesis using a fast ELISA immunoassay.
N. Gabra (1994)
Collagen in tendon, ligament, and bone healing. A current review.
S. Liu (1995)
[Healing of ligaments and tendons].
F. Hefti (1995)
Localization of collagen types I, III and V during tendon development. Changes in collagen types I and III are correlated with changes in fibril diameter.
D. Birk (1997)
The present study was supported by the Earmarked Grant CUHK4256/98M, Direct Grant 2040629, the University Grant Committee, the
10.3109/17453679709003997
Medial collateral knee ligament healing. Combined medial collateral and anterior cruciate ligament injuries studied in rabbits.
S. Woo (1997)
10.1016/0014-4827(87)90020-6
Monoclonal antibodies to a nuclear protein (PCNA/cyclin) associated with DNA replication.
K. Ogata (1987)
10.1097/00003086-199709000-00031
Effect of Basic Fibroblast Growth Factor; An In Vitro Study of Tendon Healing
B. Chan (1997)
ACL reconstruction with autogenous patellar tendon graft. Donor site consideration and potential for reharvest
K M Chan (1998)
10.1002/JOR.1100130318
Synergistic effect of growth factors on cell outgrowth from explants of rabbit anterior cruciate and medial collateral ligaments
J. Lee (1995)
10.1159/000146009
Effects of serum, fibroblast growth factor, and platelet-derived growth factor on explants of rat tail tendon: a morphological study.
L. E. Stein (1985)
10.1097/00003086-199706000-00034
Morphology and Matrix Composition During Early Tendon to Bone Healing
S. Liu (1997)



This paper is referenced by
10.7717/peerj.2231
Reconstitution of the complete rupture in musculotendinous junction using skeletal muscle-derived multipotent stem cell sheet-pellets as a “bio-bond”
H. Hashimoto (2016)
10.1007/s12178-014-9230-2
Updates in biological therapies for knee injuries: tendons
M. Demange (2014)
10.1177/230949901302100223
Review Article: Regenerative Techniques for Repair of Rotator Cuff Tears
Z. Ahmad (2013)
10.1007/s00264-007-0398-6
Stimulation of tendon repair: mechanical loading, GDFs and platelets. A mini-review
P. Aspenberg (2007)
In vitro comparison of equine tendon- and bone marrow-derived cells expanded with FGF-2 prior to culturing with tendon matrix and IGF-I
Sushmitha S Durgam (2011)
10.3109/0284186X.2012.695087
Shoulder morbidity after treatment for breast cancer is bilateral and greater after mastectomy
D. Shamley (2012)
10.1016/J.JHSA.2004.04.020
Clinical implications of growth factors in flexor tendon wound healing.
Charles S Hsu (2004)
10.1002/jor.23796
Polydeoxyribonucleotide improves tendon healing following achilles tendon injury in rats
S. H. Kang (2018)
10.1002/jor.22211
Refixation of the supraspinatus tendon in a rat model—influence of continuous growth factor application on tendon structure
S. Buchmann (2013)
Aus der Poliklinik für Zahnerhaltung und Parodontologie der Ludwig-Maximilians-Universität München
R. Hickel (2006)
10.2106/00004623-200303000-00025
Biologic aspects of flexor tendon laceration and repair.
P. Beredjiklian (2003)
10.1089/ten.TEA.2012.0453
Human iPSC-derived neural crest stem cells promote tendon repair in a rat patellar tendon window defect model.
W. Xu (2013)
10.1002/term.2000
Sustained‐release of naproxen sodium from electrospun‐aligned PLLA–PCL scaffolds
Y. S. Lui (2017)
10.2165/00007256-200535010-00006
Patellar Tendinopathy in Athletes
K. Peers (2005)
10.1016/S1013-7025(09)70028-4
Ligament Injury and Repair: Current Concepts
G. Ng (2002)
10.1002/term.1534
Recombinant fibroblast growth protein enhances healing ability of experimentally induced tendon injury in vivo
A. Oryan (2014)
10.22203/eCM.v035a22
Improved tendon healing using bFGF, BMP-12 and TGFβ1 in a rat model.
M. Majewski (2018)
The development of heparin-based materials for tissue engineering applications to treat rotator cuff tendon injuries
S. P. Seto (2014)
10.1016/J.JHSA.2004.12.006
Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro.
S. Thomopoulos (2005)
10.1016/J.JHSA.2005.10.022
Tendon tissue engineering and gene transfer: the future of surgical treatment.
Deqing Huang (2006)
10.1053/j.jfas.2011.05.002
Structural and functional modulation of early healing of full-thickness superficial digital flexor tendon rupture in rabbits by repeated subcutaneous administration of exogenous human recombinant basic fibroblast growth factor.
A. Moshiri (2011)
10.1186/s12891-016-0999-6
Stem cells and bFGF in tendon healing: Effects of lentiviral gene transfer and long-term follow-up in a rat Achilles tendon defect model
T. Kraus (2016)
10.1097/01.PRS.0000086772.72535.A4
Effect of Vascular Endothelial Growth Factor on Rat Achilles Tendon Healing
F. Zhang (2003)
Pathology of rotator cuff tendonopathy
B. Wu (2008)
10.1002/bdrc.21041
Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm.
G. Yang (2013)
10.1016/j.jhsa.2009.12.044
Technical and biological modifications for enhanced flexor tendon repair.
H. Kim (2010)
10.1002/jor.20891
CD44 deficiency improves healing tendon mechanics and increases matrix and cytokine expression in a mouse patellar tendon injury model
Heather L. Ansorge (2009)
10.1186/1471-2474-13-53
Local biochemical and morphological differences in human Achilles tendinopathy: a case control study
P. J. (2012)
10.2106/JBJS.L.01794
Stem cells and basic fibroblast growth factor failed to improve tendon healing: an in vivo study using lentiviral gene transfer in a rat model.
T. Kraus (2014)
10.1016/J.MEDENGPHY.2004.12.011
Total flavones of Hippophae rhamnoides promotes early restoration of ultimate stress of healing patellar tendon in a rat model.
S. Fu (2005)
10.1007/s00167-015-3580-1
Can platelet-rich plasma have a role in Achilles tendon surgical repair?
A. D. Carli (2015)
10.1016/j.jhsa.2007.09.007
Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options.
R. James (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar