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Tamanu Oil Potentiated Novel Sericin Emulgel Of Levocetirizine: Repurposing For Topical Delivery Against DNCB-induced Atopic Dermatitis, QbD Based Development And In Vivo Evaluation
Ravi Raj Pal, Poonam Parashar, I. Singh, S. Saraf
Published 2019 · Medicine
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Abstract The present study was aimed at preparing and evaluating levocetirizine (LCZD) loaded emulgel containing tamanu oil and sericin for atopic dermatitis (AD) therapy. The emulgel envisaged topical delivery of LCZD utilising natural antioxidants for superior therapeutic outcomes when compared with other conventional therapy. Tamanu oil based microemulsion (ME) was optimised utilising Box-Behnken design (BBD). The OPT-ME displayed globule size 379.5 ± 2.33 nm, polydispersity index 0.284, drug loading 0.41 ± 0.01% w/w, entrapment efficiency 94.34 ± 2.11% w/w and drug release 86.24 ± 4.90% respectively over a period of 24 h. The optimised formulation (OPT-ME) was further incorporated into sericin gel to form emulgel (LSE). In vivo pharmacodynamic studies revealed enhanced therapeutic potential of emulgel in terms of reduced scratching frequency and erythema score when compared with conventional gel. The superior therapeutic potential was further witnessed through histopathological and biochemical studies. The emulgel can be an alternative appropriate dosage form for the treatment of AD.
This paper references
x-3 fatty acid synergized novel nanoemulsifying system for rosuvastatin delivery: in vitro and in vivo evaluation
C B Tripathi (2018)
Topical Application of Herbal Mixture Extract Inhibits Ovalbumin- or 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis
S. R. Kim (2012)
Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis.
C. Qi (2018)
x-3 fatty acid synergized novel
3209–3223. Tripathi (2018)
The Wound Healing and Antibacterial Activity of Five Ethnomedical Calophyllum inophyllum Oils: An Alternative Therapeutic Strategy to Treat Infected Wounds
T. Léguillier (2015)
Effects of Silk Sericin on Incision Wound Healing in a Dorsal Skin Flap Wound Healing Rat Model
M. Ersel (2016)
Wound healing applications of sericin/chitosan-capped silver nanoparticles incorporated hydrogel
J. Verma (2016)
Topical application of herbal mixture extract inhibits ovalbumin-or 2,4-dinitrochlorobenzeneinduced atopic dermatitis. Evidence-based complementary and alternative medicine
S R Kim (2012)
Formulation and evaluation of mefenamic acid emulgel for topical delivery.
Rachit Khullar (2012)
Hyaluronic Acid Decorated Naringenin Nanoparticles: Appraisal of Chemopreventive and Curative Potential for Lung Cancer
Poonam Parashar (2018)
Systematic development of optimized SNEDDS of artemether with improved biopharmaceutical and antimalarial potential
C. B. Tripathi (2016)
Skin electroporation for transdermal and topical delivery.
Anne-Rose Denet (2004)
Development of Novel Elastic Vesicle-Based Topical Formulation of Cetirizine Dihydrochloride for Treatment of Atopic Dermatitis
S. Goindi (2013)
Novel genipin crosslinked atorvastatin loaded sericin nanoparticles for their enhanced antihyperlipidemic activity.
Jovita Kanoujia (2016)
Development, optimization, and characterization of a novel tea tree oil nanogel using response surface methodology
Priyam Sinha (2016)
Development, optimization, and characterization of a novel tea tree oil nanogel using response surface methodology. Drug development and industrial pharmacy
P Sinha (2016)
Recent advances in gel technologies for topical and transdermal drug delivery
K. Rehman (2014)
Self-assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery.
B. Mandal (2009)
Development and Characterization
M. Hebsur (1998)
Gelatin-based hydrogels as potential biomaterials for colonic delivery of oxaliplatin.
K. Ullah (2019)
Tamanu (Calophyllum inophyllum) – the African, Asian, Polynesian and Pacific Panacea
A. Dweck (2002)
Drug nanocarrier, the future of atopic diseases: Advanced drug delivery systems and smart management of disease.
Mei Shao (2016)
Microemulsions for topical delivery of estradiol.
S. Peltola (2003)
Immunoadsorption for treatment of severe atopic dermatitis.
Joanna Wegner (2017)
Chaulmoogra oil based methotrexate loaded topical nanoemulsion for the treatment of psoriasis
P. Rajitha (2019)
Chaulmoogra oil based methotrexate
P Rajitha (2019)
Recent advances in self-emulsifying drug delivery systems (SEDDS).
B. Singh (2014)
Development and characterization of nanostructured lipid carriers of Vetiveria zizanoides oil for therapeutic potential in prickly heat treatment
D Rawat (2015)
Recent advances in self-emulsifying
B 475–491. Singh (2014)
Atopic dermatitis: a review of topical nonsteroid therapy
Ariana Papier (2018)
Transdermal potential and anti-gout
S Singh (2017)
Novel flexible vesicles based topical formulation of levocetirizine: in vivo evaluation using oxazolone-induced atopic dermatitis in murine model
S. Goindi (2014)
Galantamine attenuates N,N‐dimethyl hydrazine induced neoplastic colon damage by inhibiting acetylcholinesterase and bimodal regulation of nicotinic cholinergic neurotransmission
S. R. Sammi (2018)
An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction.
Yu Song (2016)
Biological Activity of Polynesian Calophyllum inophyllum Oil Extract on Human Skin Cells.
Jean-Luc Ansel (2016)
Gelatin-based hydrogels as potential
K 211–222. Ullah (2019)
Antimicrobial and cytotoxic agents from Calophyllum inophyllum.
Marie C. Yimdjo (2004)
Formulation and characterization of oral rapid disintegrating tablets of levocetirizine.
S. Samvedna (2018)
Correction: green synthesis of silk sericin-capped silver nanoparticles and their potent anti-bacterial activity
P. Aramwit (2014)
ω-3 Fatty Acid Synergized Novel Nanoemulsifying System for Rosuvastatin Delivery: In Vitro and In Vivo Evaluation
C. B. Tripathi (2017)
An injectable silk sericin hydrogel
Y Song (2016)
Preparation and evaluation of antifungal efficacy of griseofulvin loaded deformable membrane vesicles in optimized guinea pig model of Microsporum canis--dermatophytosis.
N. Aggarwal (2012)
Transdermal potential and anti-gout efficacy of Febuxostat from niosomal gel
S. Singh (2017)
Anti-inflammatory Activity of Calophyllum Inophyllum Fruits Extracts☆
Muhamad Bin Zakaria (2014)
Anti-inflammatory effect of collagen tripeptide in atopic dermatitis.
Amiko Hakuta (2017)
Tamanu oil: a tropical topical remedy
C. Kilham (2004)
Outstanding animal studies in allergy II. From atopic barrier and microbiome to allergen-specific immunotherapy
E. Jensen-Jarolim (2017)
Validated derivative and ratio derivative spectrophotometric methods for the simultaneous determination of levocetirizine dihydrochloride and ambroxol hydrochloride in pharmaceutical dosage form.
O. Ali (2016)
Microemulsion-based hydrogel formulation of ibuprofen for topical delivery.
Huabing Chen (2006)
Topical Delivery of Fluconazole via Microemulsion Incorporated Hydrogel for the Management of Fungal Dermatophytosis
M. Singh (2016)
Penetration enhancers. Advanced drug delivery reviews
A C Williams (2004)
Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi pharmaceutical journal: the official publication of the saudi pharmaceutical society
R Khullar (2012)
Wound healing applications of sericin
J Verma (2017)
Topical management of striae distensae (stretch marks): prevention and therapy of striae rubrae and albae
S. Uddin (2016)
A novel atopic dermatitis model induced by topical application with dermatophagoides farinae extract in NC/Nga mice.
M. Yamamoto (2007)
In vivo antiarthritic activity of the ethanol extracts of stem bark and seeds of Calophyllum inophyllum in Freund’s complete adjuvant induced arthritis
Senthamil Selvan Perumal (2017)
Green synthesis of silk sericin-capped silver nanoparticles and their potent anti-bacterial activity
P. Aramwit (2014)
This paper is referenced by
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