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The Protective Potential Of Nitraria Retusa On Penconazole-induced Hepatic Injury In Adult Rats

M. Chaâbane, N. Soudani, K. Benjeddou, M. Turki, Fatma Ayadi Makni, T. Boudawara, N. Zeghal, Raoudha Ellouze Ghorbel
Published 2015 · Chemistry

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The protective effect of Nitraria retusa fruit extract against hepatotoxicity induced by penconazole at a dose of 67 mg/kg body weight given intraperitoneally every two days to male Wistar rats was investigated. Penconazole exposure increased malondialdehyde, hydrogen peroxide, and advanced oxidation protein product levels. Hepatic biomarkers as well as enzymatic (catalase, superoxide dismutase and glutathione peroxidase) and nonenzymatic (vitamin C, non-protein thiols and metallothioneins) antioxidant status were also altered. Treatment with N. retusa extract improved all parameters cited above. Liver histological studies confirmed the biochemical parameters. These results provide a scientific basis for the use of N. retusa fruit against hepatotoxicity.
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